Online First

July 28, 2021

Spondyloarthritis
Anterior uveitis in patients with spondyloarthritis treated with secukinumab or tumour necrosis factor inhibitors in routine care: does the choice of biological therapy matter?

Ulf Lindström, Karin Bengtsson, Tor Olofsson, Daniela Di Giuseppe, Bente Glintborg, Helena Forsblad-d'Elia, Lennart T H Jacobsson, Johan Askling

doi: 10.1136/annrheumdis-2021-220420
Rheumatoid arthritis
Risk of herpes zoster (shingles) in patients with rheumatoid arthritis under biologic, targeted synthetic and conventional synthetic DMARD treatment: data from the German RABBIT register

Imke Redeker, Katinka Albrecht, Joern Kekow, Gerd Rüdiger Burmester, Juergen Braun, Martin Schäfer, Angela Zink, Anja Strangfeld

doi: 10.1136/annrheumdis-2021-220651
Systemic sclerosis
TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis

Paôline Laurent, Benoit Allard, Pauline Manicki, Valérie Jolivel, Emeline Levionnois, Mohamed Jeljeli, Pauline Henrot, Julien Izotte, Damien Leleu, Alexis Groppi, Julien Seneschal, Joel Constans, Carlo Chizzolini, Christophe Richez, Pierre Duffau, Estibaliz Lazaro, Edouard Forcade, Thierry Schaeverbeke, Thomas Pradeu, Frédéric Batteux, Patrick Blanco, Cécile Contin-Bordes, Marie-Elise Truchetet

doi: 10.1136/annrheumdis-2020-219748

July 23, 2021

Inflammatory arthritis
Serum uric acid control for prevention of gout flare in patients with asymptomatic hyperuricaemia: a retrospective cohort study of health insurance claims and medical check-up data in Japan

Ruriko Koto, Akihiro Nakajima, Hideki Horiuchi, Hisashi Yamanaka

doi: 10.1136/annrheumdis-2021-220439

July 22, 2021

Epidemiology
Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study
Free

Victoria Furer, Tali Eviatar, Devy Zisman, Hagit Peleg, Daphna Paran, David Levartovsky, Michael Zisapel, Ofir Elalouf, Ilana Kaufman, Roni Meidan, Adi Broyde, Ari Polachek, Jonathan Wollman, Ira Litinsky, Katya Meridor, Hila Nochomovitz, Adi Silberman, Dana Rosenberg, Joy Feld, Amir Haddad, Tal Gazzit, Muna Elias, Nizar Higazi, Fadi Kharouf, Gabi Shefer, Orly Sharon, Sara Pel, Sharon Nevo, Ori Elkayam

doi: 10.1136/annrheumdis-2021-220647
Correspondence response
Response to: ‘Correspondence on ‘Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial’’ by McGonagle et al
Free

Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Jens Kristian Pedersen, Søren Andreas Just, Palle Ahlquist, Jesper Rømhild Davidsen, Anna Christine Nilsson, Richard Röttger, Mogens Kruhøffer, Julian R Marchesi, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen

doi: 10.1136/annrheumdis-2021-220910
Rheumatoid arthritis
Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry
Free

Jeffrey A Sparks, Zachary S Wallace, Andrea M Seet, Milena A Gianfrancesco, Zara Izadi, Kimme L Hyrich, Anja Strangfeld, Laure Gossec, Loreto Carmona, Elsa F Mateus, Saskia Lawson-Tovey, Laura Trupin, Stephanie Rush, Patricia Katz, Gabriela Schmajuk, Lindsay Jacobsohn, Leanna Wise, Emily L Gilbert, Ali Duarte-García, Maria O Valenzuela-Almada, Guillermo J Pons-Estel, Carolina A Isnardi, Guillermo A Berbotto, Tiffany Y -T Hsu, Kristin M D’Silva, Naomi J Patel, Lianne Kearsley-Fleet, Martin Schäfer, Sandra Lúcia Euzébio Ribeiro, Samar Al Emadi, Liselotte Tidblad, Carlo Alberto Scirè, Bernd Raffeiner, Thierry Thomas, René-Marc Flipo, Jérôme Avouac, Raphaèle Seror, Miguel Bernardes, Maria Margarida Cunha, Rebecca Hasseli, Hendrik Schulze-Koops, Ulf Müller-Ladner, Christof Specker, Viviane Angelina de Souza, Licia Maria Henrique da Mota, Ana Paula Monteiro Gomides, Philippe Dieudé, Elena Nikiphorou, Vanessa L Kronzer, Namrata Singh, Manuel F Ugarte-Gil, Beth Wallace, Akpabio Akpabio, Ranjeny Thomas, Suleman Bhana, Wendy Costello, Rebecca Grainger, Jonathan S Hausmann, Jean W Liew, Emily Sirotich, Paul Sufka, Philip C Robinson, Pedro M Machado, Jinoos Yazdany COVID-19 Global Rheumatology Alliance

doi: 10.1136/annrheumdis-2021-220418
Vasculitis
Treatment failure in giant cell arteritis

Sebastian H Unizony, Min Bao, Jian Han, Yves Luder, Andrey Pavlov, John H Stone

doi: 10.1136/annrheumdis-2021-220347

July 20, 2021

Letter
Immunotherapies and COVID-19 mortality: a multidisciplinary open data analysis based on FDA’s Adverse Event Reporting System

Maximilian Pistor, Andreas G F Hoepner, Yanan Lin, Simon Jung, Claudio L Bassetti, Andrew Chan, Anke Salmen, Robert Hoepner

doi: 10.1136/annrheumdis-2021-220679
Rheumatoid arthritis
Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis

Fenne Wouters, Marc P Maurits, Laurette van Boheemen, Marloes Verstappen, Kulveer Mankia, Xanthe M E Matthijssen, Annemarie L Dorjée, Paul Emery, Rachel Knevel, Dirkjan van Schaardenburg, René E M Toes, Annette H M van der Helm-van Mil

doi: 10.1136/annrheumdis-2021-220546
Osteoarthritis
circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1

Shuying Shen, Yute Yang, Panyang Shen, Jun Ma, Bin Fang, Qingxin Wang, Kefan Wang, Peihua Shi, Shunwu Fan, Xiangqian Fang

doi: 10.1136/annrheumdis-2021-219969
Miscellaneous
SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity
Free

Daniel Mrak, Selma Tobudic, Maximilian Koblischke, Marianne Graninger, Helga Radner, Daniela Sieghart, Philipp Hofer, Thomas Perkmann, Helmuth Haslacher, Renate Thalhammer, Stefan Winkler, Stephan Blüml, Karin Stiasny, Judith H Aberle, Josef S Smolen, Leonhard X Heinz, Daniel Aletaha, Michael Bonelli

doi: 10.1136/annrheumdis-2021-220781

July 19, 2021

Psoriatic arthritis
Treating the skin with biologics in patients with psoriasis decreases the incidence of psoriatic arthritis

Maria Laura Acosta Felquer, Luciano LoGiudice, Maria Laura Galimberti, Javier Rosa, Luis Mazzuoccolo, Enrique R Soriano

doi: 10.1136/annrheumdis-2021-220865

July 16, 2021

Letter
Pause in immunosuppressive treatment results in improved immune response to SARS-CoV-2 vaccine in autoimmune patient: a case report
Free

Basil Golding, Youri Lee, Hana Golding, Surender Khurana

doi: 10.1136/annrheumdis-2021-220993
Spondyloarthritis
Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis

Zhixiu Li, Xin Wu, Paul J Leo, Erika De Guzman, Nurullah Akkoc, Maxime Breban, Gary J Macfarlane, Mahdi Mahmoudi, Helena Marzo-Ortega, Lisa K Anderson, Lawrie Wheeler, Chung-Tei Chou, Andrew A Harrison, Simon Stebbings, Gareth T Jones, So-Young Bang, Geng Wang, Ahmadreza Jamshidi, Elham Farhadi, Jing Song, Li Lin, Mengmeng Li, James Cheng-Chung Wei, Nicholas G Martin, Margaret J Wright, MinJae Lee, Yuqin Wang, Jian Zhan, Jin-San Zhang, Xiaobing Wang, Zi-Bing Jin, Michael H Weisman, Lianne S Gensler, Michael M Ward, Mohammad Hossein Rahbar, Laura Diekman, Tae-Hwan Kim, John D Reveille, Bryan Paul Wordsworth, Huji Xu, Matthew A Brown TCRI AS Group

doi: 10.1136/annrheumdis-2020-219446
Correspondence
Correspondence on ‘SARS-CoV-2 vaccination in rituximab-treated patients: evidence for impaired humoral but inducible cellular immune response’
Free

Timm H Westhoff, Felix S Seibert, Moritz Anft, Arturo Blazquez-Navarro, Sarah Skrzypczyk, Adrian Doevelaar, Bodo Hölzer, Krystallenia Paniskaki, Sebastian Dolff, Benjamin Wilde, Oliver Witzke, Juergen Braun, Ulrik Stervbo, Nina Babel

doi: 10.1136/annrheumdis-2021-220756
Correspondence response
Response to: ‘Correspondence on ‘SARS-CoV-2 vaccination in rituximab-treated patients: evidence for impaired humoral but inducible cellular immune response’’ by Westhoff et al
Free

Michael Bonelli, Daniel Aletaha

doi: 10.1136/annrheumdis-2021-220764

July 07, 2021

Vasculitis
Ultrasound halo sign as a potential monitoring tool for patients with giant cell arteritis: a prospective analysis

Cristina Ponte, Sara Monti, Carlo Alberto Scirè, Paolo Delvino, Nikita Khmelinskii, Alessandra Milanesi, Vítor Teixeira, Fabio Brandolino, Fernando Saraiva, Carlomaurizio Montecucco, João Eurico Fonseca, Wolfgang A Schmidt, Raashid Ahmed Luqmani

doi: 10.1136/annrheumdis-2021-220306

July 06, 2021

Systemic sclerosis
Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis

Kristina Elizabeth Neergaard Clark, Corrado Campochiaro, Eszter Csomor, Adam Taylor, Katherine Nevin, Nicholas Galwey, Mary A Morse, Jennifer Singh, Yee Voan Teo, Voon H Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M Flint, Christopher P Denton

doi: 10.1136/annrheumdis-2021-220402

July 05, 2021

Correspondence
Correspondence on ‘Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis’
Free

Quirine A Dumoulin, Xanthe M E Matthijssen, Fenne Wouters, Doortje I Krijbolder, Ellis Niemantsverdriet, Annette H M van der Helm-van Mil

doi: 10.1136/annrheumdis-2021-220511
Correspondence
Correspondence on ‘Efficacy of a tight-control and treat-to-target strategy in axial spondyloarthritis: results of the open-label, pragmatic, cluster-randomised TICOSPA trial’
Free

Weijie Wang, Yung-Heng Lee, James Cheng Chung Wei

doi: 10.1136/annrheumdis-2021-220938
Osteoarthritis
14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis

Wenyu Fu, Aubryanna Hettinghouse, Yujianan Chen, Wenhuo Hu, Xiang Ding, Meng Chen, Yuanjing Ding, Jyoti Mundra, Wenhao Song, Ronghan Liu, Young-Su Yi, Mukundan Attur, Jonathan Samuels, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Chuan-ju Liu

doi: 10.1136/annrheumdis-2021-220000
Psoriatic arthritis
Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid

Nicole Yager, Suzanne Cole, Alicia Lledo Lara, Ash Maroof, Frank Penkava, Julian C Knight, Paul Bowness, Hussein Al-Mossawi

doi: 10.1136/annrheumdis-2021-220280
Correspondence response
Response to: ‘Correspondence on ‘Role of joint damage, malalignment and inflammation in articular tenderness in rheumatoid arthritis, psoriatic arthritis and osteoarthritis’’ by Dumoulin et al
Free

Irina Gessl, Daniel Aletaha, Peter Mandl

doi: 10.1136/annrheumdis-2021-220922
Rheumatoid arthritis
B cell depletion impairs vaccination-induced CD8⁺ T cell responses in a type I interferon-dependent manner

Theresa Graalmann, Katharina Borst, Himanshu Manchanda, Lea Vaas, Matthias Bruhn, Lukas Graalmann, Mario Koster, Murielle Verboom, Michael Hallensleben, Carlos Alberto Guzmán, Gerd Sutter, Reinhold E Schmidt, Torsten Witte, Ulrich Kalinke

doi: 10.1136/annrheumdis-2021-220435
Viewpoint
Nothing about us without us: involving patient collaborators for machine learning applications in rheumatology

Stephanie J W Shoop-Worrall, Katherine Cresswell, Imogen Bolger, Beth Dillon, Kimme L Hyrich, Nophar Geifman Members of the CLUSTER consortium

doi: 10.1136/annrheumdis-2021-220454

July 02, 2021

Correspondence
Correspondence on ‘Impact of COVID-19 pandemic on patients with large-vessel vasculitis in Italy: a monocentric survey’
Free

Fernando Montero, Isabel Castrejón, Julia Martínez-Barrio, Juan Carlos Nieto-González, Javier Rivera, José María Álvaro-Gracia, Juan Molina Collada

doi: 10.1136/annrheumdis-2021-220941
Psoriatic arthritis
Role of ultrasound for assessment of psoriatic arthritis patients with fibromyalgia

Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemach, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Or Carmi, Yael Lahat, Tali Eviatar, Hagit Padova, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Ori Elkayam

doi: 10.1136/annrheumdis-2021-220562
Rheumatoid arthritis
Short-term dose and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-naive patients with rheumatoid arthritis

Anthony James Ocon, George Reed, Dimitrios A Pappas, Jeffrey R Curtis, Joel M Kremer

doi: 10.1136/annrheumdis-2021-220577
Correspondence response
Response to ‘Correspondence on ‘Impact of COVID-19 pandemic on patients with large-vessels vasculitis in Italy: a monocentric survey’’ by Montero et al
Free

Alessandro Tomelleri, Lorenzo Dagna, Corrado Campochiaro

doi: 10.1136/annrheumdis-2021-220959

June 24, 2021

Letter
Successful BNT162b2 booster vaccinations in a patient with rheumatoid arthritis and initially negative antibody response
Free

Fredrik N Albach, Gerd R Burmester, Robert Biesen

doi: 10.1136/annrheumdis-2021-220834
Letter
Nail involvement in psoriatic arthritis patients is an independent risk factor for carotid plaque

Iris Jazmin Colunga-Pedraza, Dionicio Angel Galarza-Delgado, Jose Ramon Azpiri-Lopez, Alejandra Berenice Rodriguez-Romero, Natalia Guajardo-Jauregui, Jesus Alberto Cardenas-de la Garza, Salvador Lugo-Perez, Alejandro Meza-Garza, Julieta Loya-Acosta, Andrea Cecilia Garza-Acosta

doi: 10.1136/annrheumdis-2021-220782

June 23, 2021

Psoriatic arthritis
Effectiveness of IL-12/23 inhibition (ustekinumab) versus tumour necrosis factor inhibition in psoriatic arthritis: observational PsABio study results

Josef S Smolen, Stefan Siebert, Tatiana V Korotaeva, Carlo Selmi, Paul Bergmans, Elisa Gremese, Beatriz Joven-Ibáñez, Gkikas Katsifis, Wim Noël, Michael T Nurmohamed, Pascal Richette, Petros P Sfikakis, Kurt de Vlam, Elke Theander, Laure Gossec

doi: 10.1136/annrheumdis-2021-220263
Systemic lupus erythematosus
Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients

Katerina Chavatza, Myrto Kostopoulou, Dionysis Nikolopoulos, Ourania Gioti, Konstantina Togia, Laura Andreoli, Martin Aringer, John Boletis, Andrea Doria, Frederic A Houssiau, David Jayne, Marta Mosca, Elisabet Svenungsson, Angela Tincani, George Bertsias, Antonis Fanouriakis, Dimitrios T Boumpas

doi: 10.1136/annrheumdis-2021-220438
Letter
Early reduction in circulating monocyte count predicts maintenance of remission in patients with rheumatoid arthritis treated with anti-TNF therapy

Muhammad Ruhul Amin Shipa, Raj Amarnani, Su-Ann Yeoh, M D Mainuddin, Michael R Ehrenstein

doi: 10.1136/annrheumdis-2021-220642
Correspondence response
Response to: ‘Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19- associated cytokine storm syndrome: results of the CHIC study’’ by Klopfenstein et al
Free

Robert BM Landewé, Sofia Ramiro, Rémy L M Mostard

doi: 10.1136/annrheumdis-2021-220787
Correspondence
Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study’
Free

Timothée Klopfenstein, Vincent Gendrin, Thierry Conrozier, Aurélie Gerazime, Marc Puyraveau, Souheil Zayet

doi: 10.1136/annrheumdis-2021-220771
Treatment
Comparative effectiveness of two adalimumab biosimilars in 1318 real-world patients with inflammatory rheumatic disease mandated to switch from originator adalimumab: nationwide observational study emulating a randomised clinical trial

Hafsah Nabi, Stylianos Georgiadis, Anne Gitte Loft, Oliver Hendricks, Dorte Vendelbo Jensen, Marlene Andersen, Stavros Chrysidis, Ada Colic, Kamilla Danebod, Mohamad Redha Hussein, Maren Høgberget Kalisz, Salome Kristensen, Niels Lomborg, Natalia Manilo, Heidi Lausten Munk, Jens Kristian Pedersen, Johnny Lillelund Raun, Frank Mehnert, Niels Steen Krogh, Merete Lund Hetland, Bente Glintborg

doi: 10.1136/annrheumdis-2021-219951

June 22, 2021

Correspondence
Correspondence on ‘Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial’
Free

Dennis G McGonagle, Charlie Bridgewood, Helena Marzo-Ortega

doi: 10.1136/annrheumdis-2021-220871

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