Article Text

Download PDFPDF
Global burden of early-onset osteoarthritis, 1990–2019: results from the Global Burden of Disease Study 2019
  1. Qianlin Weng1,
  2. Qiu Chen1,
  3. Ting Jiang1,2,3,4,
  4. Yuqing Zhang5,6,
  5. Weiya Zhang7,8,
  6. Michael Doherty7,8,
  7. Junqing Xie9,
  8. Ke Liu1,
  9. Jiatian Li1,
  10. Tuo Yang10,
  11. Jie Wei1,2,3,11,
  12. Guanghua Lei1,2,3,12,
  13. Chao Zeng1,2,3,11,12
  1. 1Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China
  2. 2Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China
  3. 3Hunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, China
  4. 4Department of Ultrasonography, Xiangya Hospital, Central South University, Changsha, China
  5. 5Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  6. 6The Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
  7. 7Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK
  8. 8Pain Centre Versus Arthritis UK, Nottingham, UK
  9. 9Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
  10. 10Health Management Center, Xiangya Hospital, Central South University, Changsha, China
  11. 11Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China
  12. 12National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
  1. Correspondence to Professor Guanghua Lei, Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China; lei_guanghua{at}csu.edu.cn; Professor Jie Wei, Department of Epidemiology and Health Statistics, Xiangya school of Public Health, Central South University, Changsha, Hunan, China; weij1988{at}csu.edu.cn; Professor Chao Zeng, Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, China; zengchao{at}csu.edu.cn

Abstract

Objectives Early-onset osteoarthritis (OA) is an emerging health issue amidst the escalating prevalence of overweight and obesity. However, there are scant data on its disease, economic burden and attributable burden due to high body mass index (BMI).

Methods Using data from the Global Burden of Diseases Study 2019, we examined the numbers of incident cases, prevalent cases, years lived with disability (YLDs) and corresponding age-standardised rates for early-onset OA (diagnosis before age 55) from 1990 to 2019. The case definition was symptomatic and radiographically confirmed OA in any joint. The average annual percentage changes (AAPCs) of the age-standardised rates were calculated to quantify changes. We estimated the economic burden of early-onset OA and attributable burden to high BMI.

Results From 1990 to 2019, the global incident cases, prevalent cases and YLDs of early-onset OA were doubled. 52.31% of incident OA cases in 2019 were under 55 years. The age-standardised rates of incidence, prevalence and YLDs increased globally and for countries in all Sociodemographic Index (SDI) quintiles (all AAPCs>0, p<0.05), with the fastest increases in low-middle SDI countries. 98.04% of countries exhibited increasing trends in all age-standardised rates. Early-onset OA accounts for US$46.17 billion in healthcare expenditure and US$60.70 billion in productivity loss cost in 2019. The attributable proportion of high BMI for early-onset OA increased globally from 9.41% (1990) to 15.29% (2019).

Conclusions Early-onset OA is a developing global health problem, causing substantial economic costs in most countries. Targeted implementation of cost-effective policies and preventive intervention is required to address the growing health challenge.

  • Epidemiology
  • Health services research
  • Osteoarthritis

Data availability statement

Data are available in a public, open access repository.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Data availability statement

Data are available in a public, open access repository.

View Full Text

Footnotes

  • JW, GL and CZ are joint senior authors.

  • Handling editor Josef S Smolen

  • QW, QC and TJ contributed equally.

  • Contributors CZ, GL and JW have full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. CZ, GL, JW, JX, YZ, WZ and MD conceived and designed the study. All authors have read, provided critical feedback on intellectual content and approved the final manuscript. QW and QC primary responsibility for seeking, cataloging, extracting or cleaning data. QW, QC and TJ designing or coding figures and tables. QW, QC and TJ analysed the data. QW, QC and TJ drafted the manuscript. GL is responsible for the overall content as the guarantor.

  • Funding This work was supported by the National Key Research and Development Plan (2022YFC3601900, 2022YFC3601901 and 2022YFC2505500), the National Natural Science Foundation of China (81930071, 82072502, 82372474 and U21A20352), Project Program of National Clinical Research Center for Geriatric Disorders (Xiangya Hospital, 2020LNJJ03, 2021LNJJ06), the Key Research and Development Program of Hunan Province (2021SK2017), the Natural Science Foundation of Hunan Province (2022JJ20100, 2023JJ30893), and the Central South University Innovation-Driven Research Programme (2023CXQD031).

  • Map disclaimer The inclusion of any map (including the depiction of any boundaries therein), or of any geographic or locational reference, does not imply the expression of any opinion whatsoever on the part of BMJ concerning the legal status of any country, territory, jurisdiction or area or of its authorities. Any such expression remains solely that of the relevant source and is not endorsed by BMJ. Maps are provided without any warranty of any kind, either express or implied.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.