You are here

  • Home
  • Archive
  • Volume 62, Issue 3
  • Response of mononuclear cells to lipopolysaccharide and CpG oligonucleotide stimulation: possible additive effect in rheumatoid inflammation

Article Text

Article menu
Download PDFPDF
Letter
Response of mononuclear cells to lipopolysaccharide and CpG oligonucleotide stimulation: possible additive effect in rheumatoid inflammation
  1. B Tolusso,
  2. M Fabris,
  3. E Di Poi,
  4. R Assaloni,
  5. P Tomietto,
  6. G F Ferraccioli
  1. Division of Rheumatology, DPMSC, School of Medicine, University of Udine, Italy
  1. Correspondence to:
    Professor G F Ferraccioli, Division of Rheumatology, DPMSC, School of Medicine, University of Udine, 33100 Udine, Italy;
    gf.ferraccioli{at}med.uniud.it

https://doi.org/10.1136/ard.62.3.284

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    The relationship between infections and autoimmune inflammation is of paramount importance in all chronic inflammatory diseases.1 The crucial step is the interaction between the Toll-like receptor family and bacterial components, which can lead to activation of phagocytic and dendritic cells.2,3 Whether bacterial components may indeed reactivate autoimmune inflammation is at present still unclear. However, it is well known that oligonucleotides containing unmethylated CpG sequences (CpG-ODN), while stimulating bacterial DNA, might have immunostimulatory activity.3 We have recently presented data suggesting that moderate infections such as upper-lower respiratory or urinary tracts infections may reactivate rheumatoid arthritis (RA) in patients receiving etanercept.4

    There is evidence in experimental animals2,3 that Toll-like receptor 4 (activated by lipolysaccharide (LPS)) can induce a cytokine response, whereas Toll-like receptor 9, activated by CpG-ODN, induces mononuclear cell activation in a much more restricted manner. Especially in humans, …

    View Full Text

    Footnotes

    • B Tolusso and M Fabris contributed equally to this work.