Article Text

AB0205 Il-22 Serum Levels as A Biomarker for Erosive Disease in Rheumatoid Arthritis
  1. J. Leipe,
  2. H. Schulze-Koops,
  3. A. Skapenko
  1. Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany


Background Consistent with models of experimental arthritis implicating IL-22 in the development of joint destruction we could previously demonstrate that elevated IL-22 serum levels were associated with the development of erosive disease in patients with early RA.

Objectives To study value of IL-22 as a marker for erosive disease in established RA, to assess whether IL-22 is increased in other joint destructive rheumatic diseases, and to evaluate the influence of comorbidities on IL-22 serum levels.

Methods We measured serum IL-22 levels by Enzyme-Linked Immunosorbant Assay (ELISA) and analyzed their correlation to erosive disease (assessed by radiographs of hand and feet) and clinical parameters in patients with established RA (n=142), psoriatic arthritis (n=15), gout (n=15), age-matched patients with hypertension (n=10), diabetes (n=10), coronary heart disease (n=10), and healthy individuals as controls.

Results 81 of 142 patients with established RA demonstrated elevated IL-22 levels compared with the range of healthy controls. A significant greater percentage of these “IL-22 high” patients (59%) demonstrated erosive disease compared the “IL-22 normal” patients (37%, p<0.05). In the “IL-22 high” compared to “IL-22 normal” group the fractions of patients positive for RF (70% vs 83%) and ACPA (74% vs 64%) were slightly higher, however not statistically significant different. Similar, measures of disease activity including DAS28 (2.3 vs 2.8) and CRP (0.5 vs 0.3 mg/dl) only tended to be higher in the “IL-22 high” than the “IL-22 low” group. Irrespective of erosive joint disease, patients with psoriatic arthritis and gout demonstrated lower IL-22 levels compared to established RA and only slightly higher than healthy individuals. Patients with hypertension, diabetes and coronary heart disease had IL-22 serum levels comparable to healthy controls.

Conclusions High IL-22 levels are associated with erosive disease also in established RA, potentially in parts independent of serology, and might serve as a marker for joint destruction also in this cohort.

Disclosure of Interest None declared

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.