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Online First

Online First articles have been peer reviewed, accepted for publication, published online and indexed by PubMed; they have not yet been assigned to a journal issue. When an article is published in an issue it will be removed from this page.

Online First articles are copy-edited, typeset and approved by the author before publication and we aim to post each article within 3 weeks of acceptance.

Articles appear on this page in reverse chronological order; you may also view by section by clicking on the link at the top of the column to the right.

More about Online First, including how to cite >>

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14 June 2013

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Clinical and epidemiological research: Extended report: Weight loss and achievement of minimal disease activity in patients with psoriatic arthritis starting treatment with tumour necrosis factor α blockers

Matteo Nicola Dario Di Minno,
Rosario Peluso,
Salvatore Iervolino,
Anna Russolillo,
Roberta Lupoli,
Raffaele Scarpa,
on behalf of the CaRRDs Study Group

Ann Rheum Dis Published Online First: 14 June 2013 doi:10.1136/annrheumdis-2012-202812

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13 June 2013

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Clinical and epidemiological research: Extended report: Assessment of short-term symptomatic efficacy of tocilizumab in ankylosing spondylitis: results of randomised, placebo-controlled trials

Joachim Sieper,
Benjamin Porter-Brown,
Liz Thompson,
Olivier Harari,
Maxime Dougados

Ann Rheum Dis Published Online First: 13 June 2013 doi:10.1136/annrheumdis-2013-203559

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12 June 2013

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Clinical and epidemiological research: Extended report: Health-related utility values of patients with primary Sjögren's syndrome and its predictors

Dennis Lendrem,
Sheryl Mitchell,
Peter McMeekin,
Simon Bowman,
Elizabeth Price,
Colin T Pease,
Paul Emery,
Jacqueline Andrews,
Peter Lanyon,
John Hunter,
Monica Gupta,
Michele Bombardieri,
Nurhan Sutcliffe,
Costantino Pitzalis,
John McLaren,
Annie Cooper,
Marian Regan,
Ian Giles,
David Isenberg,
Saravanan Vadivelu,
David Coady,
Bhaskar Dasgupta,
Neil McHugh,
Steven Young-Min,
Robert Moots,
Nagui Gendi,
Mohammed Akil,
Bridget Griffiths,
Wan-Fai Ng

Ann Rheum Dis Published Online First: 12 June 2013 doi:10.1136/annrheumdis-2012-202863

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10 June 2013

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Clinical and epidemiological research: Concise report: Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis

M M Schoels,
J Braun,
M Dougados,
P Emery,
O Fitzgerald,
A Kavanaugh,
T K Kvien,
R Landewé,
T Luger,
P Mease,
I Olivieri,
J Reveille,
C Ritchlin,
M Rudwaleit,
J Sieper,
J S Smolen,
M de Wit,
D van der Heijde

Ann Rheum Dis Published Online First: 5 June 2013 doi:10.1136/annrheumdis-2013-203860

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8 June 2013

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Clinical and epidemiological research: Extended Report: Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force

Josef S Smolen,
Jürgen Braun,
Maxime Dougados,
Paul Emery,
Oliver FitzGerald,
Philip Helliwell,
Arthur Kavanaugh,
Tore K Kvien,
Robert Landewé,
Thomas Luger,
Philip Mease,
Ignazio Olivieri,
John Reveille,
Christopher Ritchlin,
Martin Rudwaleit,
Monika Schoels,
Joachim Sieper,
Martinus de Wit,
Xenofon Baraliakos,
Neil Betteridge,
Ruben Burgos-Vargas,
Eduardo Collantes-Estevez,
Atul Deodhar,
Dirk Elewaut,
Laure Gossec,
Merryn Jongkees,
Mara Maccarone,
Kurt Redlich,
Filip van den Bosch,
James Cheng-Chung Wei,
Kevin Winthrop,
Désirée van der Heijde

Ann Rheum Dis Published Online First: 8 June 2013 doi:10.1136/annrheumdis-2013-203419

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Clinical and epidemiological research: Extended report: Non-steroidal anti-inflammatory drugs and risk of cardiovascular disease in patients with rheumatoid arthritis: a nationwide cohort study

Jesper Lindhardsen,
Gunnar Hilmar Gislason,
Søren Jacobsen,
Ole Ahlehoff,
Anne-Marie Schjerning Olsen,
Ole Rintek Madsen,
Christian Torp-Pedersen,
Peter Riis Hansen

Ann Rheum Dis Published Online First: 8 June 2013 doi:10.1136/annrheumdis-2012-203137

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7 June 2013

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Clinical and epidemiological research: Extended report: Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids

Marie B Condon,
Damien Ashby,
Ruth J Pepper,
H Terence Cook,
Jeremy B Levy,
Megan Griffith,
Tom D Cairns,
Liz Lightstone

Ann Rheum Dis Published Online First: 5 June 2013 doi:10.1136/annrheumdis-2012-202844

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Basic and translational research: Extended report: Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis

Devi Rani Sagar,
Sadaf Ashraf,
Luting Xu,
James J Burston,
Matthew R Menhinick,
Caroline L Poulter,
Andrew J Bennett,
David A Walsh,
Victoria Chapman

Ann Rheum Dis Published Online First: 30 May 2013 doi:10.1136/annrheumdis-2013-203260

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Clinical and epidemiological research: Extended report: Early remission is associated with improved survival in patients with inflammatory polyarthritis: results from the Norfolk Arthritis Register

Carlo A Scirè,
Mark Lunt,,
Tarnya Marshall,
Deborah P M Symmons,
Suzanne M M Verstappen

Ann Rheum Dis Published Online First: 7 June 2013 doi:10.1136/annrheumdis-2013-203339

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6 June 2013

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Review: Drug therapy in undifferentiated arthritis: a systematic literature review

K V C Wevers-de Boer,
L Heimans,
T W J Huizinga,
C F Allaart

Ann Rheum Dis Published Online First: 6 June 2013 doi:10.1136/annrheumdis-2012-203165

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Clinical and epidemiological research: Extended report: The longitudinal relationship between changes in body weight and changes in medial tibial cartilage, and pain among community-based adults with and without meniscal tears

Andrew J Teichtahl,
Anita E Wluka,
Yuanyuan Wang,
Boyd J Strauss,
Joseph Proietto,
John B Dixon,
Graeme Jones,
Andrew Forbes,
Susan Kouloyan-Ilic,
Johanne Martel-Pelletier,
Jean-Pierre Pelletier,
Flavia M Cicuttini

Ann Rheum Dis Published Online First: 6 June 2013 doi:10.1136/annrheumdis-2013-203210

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Clinical and epidemiological research: Extended report: Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints

Daniel Prieto-Alhambra,
Andrew Judge,
M Kassim Javaid,
Cyrus Cooper,
Adolfo Diez-Perez,
Nigel K Arden

Ann Rheum Dis Published Online First: 6 June 2013 doi:10.1136/annrheumdis-2013-203355

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1 June 2013

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Basic and translational research: Extended report: Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

Federico Pratesi,
Ilaria Dioni,
Cristina Tommasi,
Maria Claudia Alcaro,
Ilaria Paolini,
Francesca Barbetti,
Francesca Boscaro,
Filomena Panza,
Ilaria Puxeddu,
Paolo Rovero,
Paola Migliorini

Ann Rheum Dis Published Online First: 1 June 2013 doi:10.1136/annrheumdis-2012-202765

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Basic and translational research: Extended report: Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Raewyn C Poulsen,
Anna C Watts,
Richard J Murphy,
Sarah J Snelling,
Andrew J Carr,
Philippa A Hulley

Ann Rheum Dis Published Online First: 1 June 2013 doi:10.1136/annrheumdis-2012-203146

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Basic and translational research: Extended report: MICA, a gene contributing strong susceptibility to ankylosing spondylitis

Xiaodong Zhou,
Jiucun Wang,
Hejian Zou,
Michael M Ward,
Michael H Weisman,
Maribel G Espitia,
Xiangjun Xiao,
Effie Petersdorf,
Emmanuel Mignot,
Javier Martin,
Lianne S Gensler,
Paul Scheet,
John D Reveille

Ann Rheum Dis Published Online First: 1 June 2013 doi:10.1136/annrheumdis-2013-203352

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Letter: Classification of vasculitis: EMA classification using CHCC 2012 definitions

Rita Abdulkader,
Suzanne E Lane,
David G I Scott,
Richard A Watts

Ann Rheum Dis Published Online First: 1 June 2013 doi:10.1136/annrheumdis-2013-203511

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31 May 2013

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Clinical and epidemiological research: Extended report: A non-inferiority trial of an attenuated combination strategy (‘COBRA-light’) compared to the original COBRA strategy: clinical results after 26 weeks

Debby den Uyl,
Marieke ter Wee,
Maarten Boers,
Pit Kerstens,
Alexandre Voskuyl,
Mike Nurmohamed,
Hennie Raterman,
Dirkjan van Schaardenburg,
Nancy van Dillen,
Ben Dijkmans,
Willem Lems

Ann Rheum Dis Published Online First: 19 April 2013 doi:10.1136/annrheumdis-2012-202818

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30 May 2013

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Clinical and epidemiological research: Extended report: Immunogenicity and safety of the bivalent HPV vaccine in female patients with juvenile idiopathic arthritis: a prospective controlled observational cohort study

Marloes W Heijstek,
Mirte Scherpenisse,
Noortje Groot,
Carline Tacke,
Rutger M Schepp,
Anne-Marie Buisman,
Guy A M Berbers,
Fiona R M van der Klis,
Nico M Wulffraat

Ann Rheum Dis Published Online First: 30 May 2013 doi:10.1136/annrheumdis-2013-203429

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Basic and translational research: Extended report: Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

Tokio Matsuzaki,
Takehiko Matsushita,
Koji Takayama,
Tomoyuki Matsumoto,
Kotaro Nishida,
Ryosuke Kuroda,
Masahiro Kurosaka

Ann Rheum Dis Published Online First: 30 May 2013 doi:10.1136/annrheumdis-2012-202620

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Clinical and epidemiological research: Extended report: Evaluation of low-dose rituximab for the retreatment of patients with active rheumatoid arthritis: a non-inferiority randomised controlled trial

Xavier Mariette,
Stephanie Rouanet,
Jean Sibilia,
Bernard Combe,
Xavier Le Loët,
Jacques Tebib,
Rosemary Jourdan,
Maxime Dougados

Ann Rheum Dis Published Online First: 30 May 2013 doi:10.1136/annrheumdis-2013-203480

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Clinical and epidemiological research: Concise report: Biologic discontinuation studies: a systematic review of methods

Kazuki Yoshida,
Yoon-Kyoung Sung,
Arthur Kavanaugh,
Sang-Cheol Bae,
Michael E Weinblatt,
Mitsumasa Kishimoto,
Kazuo Matsui,
Shigeto Tohma,
Daniel H Solomon

Ann Rheum Dis Published Online First: 30 May 2013 doi:10.1136/annrheumdis-2013-203302

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Letter: Strontium and cardiovascular events

Mark J Bolland,
Andrew Grey

Ann Rheum Dis Published Online First: 30 May 2013 doi:10.1136/annrheumdis-2013-203895

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28 May 2013

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Clinical and epidemiological research: Extended Report: Association of fine specificity and repertoire expansion of anticitrullinated peptide antibodies with rheumatoid arthritis associated interstitial lung disease

Jon T Giles,
Sonye K Danoff,
Jeremy Sokolove,
Catriona A Wagner,
Robert Winchester,
Dimitrios A Pappas,
Stanley Siegelman,
Geoff Connors,
William H Robinson,
Joan M Bathon

Ann Rheum Dis Published Online First: 28 May 2013 doi:10.1136/annrheumdis-2012-203160

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Clinical and epidemiological research: Extended report: Analysis and modelling of cholesterol and high-density lipoprotein cholesterol changes across the range of C-reactive protein levels in clinical practice as an aid to better understanding of inflammation–lipid interactions

Hanna Johnsson,
Maurizio Panarelli,
Allan Cameron,
Naveed Sattar

Ann Rheum Dis Published Online First: 28 May 2013 doi:10.1136/annrheumdis-2013-203293

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Clinical and epidemiological research: Extended report: Three trajectories of activity limitations in early symptomatic knee osteoarthritis: a 5-year follow-up study

Jasmijn F M Holla,
Marike van der Leeden,
Martijn W Heymans,
Leo D Roorda,
Sita M A Bierma-Zeinstra,
Maarten Boers,
Willem F Lems,
Martijn PM Steultjens,
Joost Dekker

Ann Rheum Dis Published Online First: 28 May 2013 doi:10.1136/annrheumdis-2012-202984

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Basic and translational research: Extended report: Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls

Katherine P Liao,
Dorothée Diogo,
Jing Cui,
Tianxi Cai,
Yukinori Okada,
Vivian S Gainer,
Shawn N Murphy,
Namrata Gupta,
Daniel Mirel,
Ashwin N Ananthakrishnan,
Peter Szolovits,
Stanley Y Shaw,
Soumya Raychaudhuri,
Susanne Churchill,
Isaac Kohane,
Elizabeth W Karlson,
Robert M Plenge

Ann Rheum Dis Published Online First: 28 May 2013 doi:10.1136/annrheumdis-2012-203202

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Clinical and epidemiological research: Extended report: A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study

L Heimans,
K V C Wevers-de Boer,
K Visser,
R J Goekoop,
M van Oosterhout,
J B Harbers,
C Bijkerk,
I Speyer,
M P D M de Buck,
P B J de Sonnaville,
B A M Grillet,
T W J Huizinga,
C F Allaart

Ann Rheum Dis Published Online First: 28 May 2013 doi:10.1136/annrheumdis-2013-203243

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25 May 2013

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Letter: Independent relationship between circulating resistin concentrations and endothelial activation in rheumatoid arthritis

Patrick H Dessein,
Gavin R Norton,
Angela J Woodiwiss,
Ahmed Solomon

Ann Rheum Dis Published Online First: 25 May 2013 doi:10.1136/annrheumdis-2013-203587

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24 May 2013

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Clinical and epidemiological research: Extended Report: Validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with early spondyloarthritis from the Esperanza programme

C Fernández-Espartero,
E de Miguel,
E Loza,
E Tomero,
M Gobbo,
M A Descalzo,
E Collantes-Estévez,
J Mulero,
S Muñoz-Fernández,
P Zarco,
L Carmona

Ann Rheum Dis Published Online First: 24 May 2013 doi:10.1136/annrheumdis-2012-202976

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Clinical and epidemiological research: Extended Report: Ultrasound-detected musculoskeletal urate crystal deposition: which joints and what findings should be assessed for diagnosing gout?

Esperanza Naredo,
Jacqueline Uson,
Mercedes Jiménez-Palop,
Agustín Martínez,
Esther Vicente,
Elia Brito,
Ana Rodríguez,
Francisco Javier Cornejo,
Santos Castañeda,
María Jesús Martínez,
Jesús Sanz,
Ingrid Möller,
Enrique Batlle-Gualda,
Jesús Garrido,
Eliseo Pascual

Ann Rheum Dis Published Online First: 24 May 2013 doi:10.1136/annrheumdis-2013-203487

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22 May 2013

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Basic and translational research: Extended Report: The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

Clara Dees,
Inga Schlottmann,
Robin Funke,
Alfiya Distler,
Katrin Palumbo-Zerr,
Pawel Zerr,
Neng-Yu Lin,
Christian Beyer,
Oliver Distler,
Georg Schett,
Jörg H W Distler

Ann Rheum Dis Published Online First: 22 May 2013 doi:10.1136/annrheumdis-2012-203194

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21 May 2013

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Clinical and epidemiological research: Extended report: Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study

Gerd Horneff,
Ruben Burgos-Vargas,
Tamas Constantin,
Ivan Foeldvari,
Jelena Vojinovic,
Vyacheslav G Chasnyk,
Joke Dehoorne,
Violeta Panaviene,
Gordana Susic,
Valda Stanevica,
Katarzyna Kobusinska,
Zbigniew Zuber,
Richard Mouy,
Ingrida Rumba-Rozenfelde,
Luciana Breda,
Pavla Dolezalova,
Chantal Job-Deslandre,
Nico Wulffraat,
Daniel Alvarez,
Chuanbo Zang,
Joseph Wajdula,
Deborah Woodworth,
Bonnie Vlahos,
Alberto Martini,
Nicolino Ruperto

Ann Rheum Dis Published Online First: 21 May 2013 doi:10.1136/annrheumdis-2012-203046

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Clinical and epidemiological research: Extended report: Efficacy and safety of infliximab plus naproxen versus naproxen alone in patients with early, active axial spondyloarthritis: results from the double-blind, placebo-controlled INFAST study, Part 1

J Sieper,
J Lenaerts,
J Wollenhaupt,
M Rudwaleit,
V I Mazurov,
L Myasoutova,
S Park,
Y Song,
R Yao,
D Chitkara,
N Vastesaeger

Ann Rheum Dis Published Online First: 21 May 2013 doi:10.1136/annrheumdis-2012-203201

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Letter: Methotrexate plus prednisone in patients with relapsing idiopathic retroperitoneal fibrosis

Federico Alberici,
Alessandra Palmisano,
Maria L Urban,
Federica Maritati,
Elena Oliva,
Lucio Manenti,
Stefania Ferretti,
Rocco Cobelli,
Carlo Buzio,
Augusto Vaglio

Ann Rheum Dis Published Online First: 21 May 2013 doi:10.1136/annrheumdis-2013-203267

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Letter: Systemic literature review of the performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: good news of debatable significance

H Zeidler

Ann Rheum Dis Published Online First: 21 May 2013 doi:10.1136/annrheumdis-2013-203842

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Basic and translational research: Extended Report: A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis

D P C de Rooy,
A Zhernakova,
R Tsonaka,
A Willemze,
B A S Kurreeman,
G Trynka,
L van Toorn,
R E M Toes,
T W J Huizinga,
J J Houwing-Duistermaat,
P K Gregersen,
A H M van der Helm-van Mil

Ann Rheum Dis Published Online First: 21 May 2013 doi:10.1136/annrheumdis-2013-203375

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Clinical and epidemiological research: Extended report: A randomised, double-blind, parallel-group study to demonstrate equivalence in efficacy and safety of CT-P13 compared with innovator infliximab when coadministered with methotrexate in patients with active rheumatoid arthritis: the PLANETRA study

Dae Hyun Yoo,
Pawel Hrycaj,
Pedro Miranda,
Edgar Ramiterre,
Mariusz Piotrowski,
Sergii Shevchuk,
Volodymyr Kovalenko,
Nenad Prodanovic,
Mauricio Abello-Banfi,
Sergio Gutierrez-Ureña,
Luis Morales-Olazabal,
Michael Tee,
Renato Jimenez,
Omid Zamani,
Sang Joon Lee,
HoUng Kim,
Won Park,
Ulf Müller-Ladner

Ann Rheum Dis Published Online First: 16 May 2013 doi:10.1136/annrheumdis-2012-203090

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18 May 2013

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Clinical and epidemiological research: Extended Report: Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study

J Gerry Coghlan,
Christopher P Denton,
Ekkehard Grünig,
Diana Bonderman,
Oliver Distler,
Dinesh Khanna,
Ulf Müller-Ladner,
Janet E Pope,
Madelon C Vonk,
Martin Doelberg,
Harbajan Chadha-Boreham,
Harald Heinzl,
Daniel M Rosenberg,
Vallerie V McLaughlin,
James R Seibold

Ann Rheum Dis Published Online First: 18 May 2013 doi:10.1136/annrheumdis-2013-203301

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Letter: Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: data from CHECK, a cohort study of early osteoarthritis

Harry Sprot

Ann Rheum Dis Published Online First: 18 May 2013 doi:10.1136/annrheumdis-2013-203805

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17 May 2013

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Basic and translational research: Extended Report: Autoantibodies against CD74 in spondyloarthritis

N T Baerlecken,
S Nothdorft,
G H Stummvoll,
J Sieper,
M Rudwaleit,
S Reuter,
T Matthias,
R E Schmidt,
T Witte

Ann Rheum Dis Published Online First: 17 May 2013 doi:10.1136/annrheumdis-2012-202208

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Basic and translational research: Extended Report: Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

Rebeccah J Mathews,
James I Robinson,
Michele Battellino,
Chi Wong,
John C Taylor,
Steve Eyre,
Sarah M Churchman,
Anthony G Wilson,
John D Isaacs,
Kimme Hyrich,
Anne Barton,
Darren Plant,
Sinisa Savic,
Graham P Cook,
Piercarlo Sarzi-Puttini,
Paul Emery,
Jennifer H Barrett,
Ann W Morgan,
Michael F McDermott

Ann Rheum Dis Published Online First: 17 May 2013 doi:10.1136/annrheumdis-2013-203276

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Clinical and epidemiological research: Extended Report: Primary Sjögren's syndrome and malignancy risk: a systematic review and meta-analysis

Yan Liang,
Zaixing Yang,
Baodong Qin,
Renqian Zhong

Ann Rheum Dis Published Online First: 17 May 2013 doi:10.1136/annrheumdis-2013-203305

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16 May 2013

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Clinical and epidemiological research: Extended report: A randomised, double-blind, multicentre, parallel-group, prospective study comparing the pharmacokinetics, safety, and efficacy of CT-P13 and innovator infliximab in patients with ankylosing spondylitis: the PLANETAS study

Won Park,
Pawel Hrycaj,
Slawomir Jeka,
Volodymyr Kovalenko,
Grygorii Lysenko,
Pedro Miranda,
Helena Mikazane,
Sergio Gutierrez-Ureña,
MieJin Lim,
Yeon-Ah Lee,
Sang Joon Lee,
HoUng Kim,
Dae Hyun Yoo,
Jürgen Braun

Ann Rheum Dis Published Online First: 16 May 2013 doi:10.1136/annrheumdis-2012-203091

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Clinical and epidemiological research: Concise report: Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial

H Haibel,
C Fendler,
J Listing,
J Callhoff,
J Braun,
J Sieper

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2012-203055

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11 May 2013

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Clinical and epidemiological research: Extended Report: A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies

Sandra Garcês,
Marília Antunes,
Elizabeth Benito-Garcia,
José Canas da Silva,
Lucien Aarden,
Jocelyne Demengeot

Ann Rheum Dis Published Online First: 11 May 2013 doi:10.1136/annrheumdis-2013-203296

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Letter: Effect of bariatric surgery on the inflammatory response to monosodium urate crystals: a prospective study

Nicola Dalbeth,
Bregina Pool,
Shelley Yip,
Jillian Cornish,
Rinki Murphy

Ann Rheum Dis Published Online First: 11 May 2013 doi:10.1136/annrheumdis-2013-203545

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10 May 2013

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Basic and translational research: Concise Report: Regulatory B cells in ANCA-associated vasculitis

B Wilde,
M Thewissen,
J Damoiseaux,
S Knippenberg,
M Hilhorst,
P van Paassen,
O Witzke,
J W Cohen Tervaert

Ann Rheum Dis Published Online First: 10 May 2013 doi:10.1136/annrheumdis-2012-202986

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Basic and translational research: Concise Report: Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis

Xiao-Xiang Chen,
Wolfgang Baum,
Denise Dwyer,
Michael Stock,
Kay Schwabe,
Hua-Zhu Ke,
Marina Stolina,
Georg Schett,
Aline Bozec

Ann Rheum Dis Published Online First: 10 May 2013 doi:10.1136/annrheumdis-2013-203345

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9 May 2013

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Clinical and epidemiological research: Extended Report: Postoperative effects of neuromuscular exercise prior to hip or knee arthroplasty: a randomised controlled trial

Allan Villadsen,
Søren Overgaard,
Anders Holsgaard-Larsen,
Robin Christensen,
Ewa M Roos

Ann Rheum Dis Published Online First: 9 May 2013 doi:10.1136/annrheumdis-2012-203135

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Letter: Fast relapse upon discontinuation of tumour necrosis factor blocking therapy in patients with peripheral spondyloarthritis

Jacqueline E Paramarta,
Tanja F Heijda,
Dominique L Baeten

Ann Rheum Dis Published Online First: 9 May 2013 doi:10.1136/annrheumdis-2013-203327

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Clinical and epidemiological research: Concise Report: Long-term outcome of Rheumatoid Arthritis defined according to the 2010-classification criteria

L E Burgers,
J A B van Nies,
L Y Ho,
D P C de Rooy,
T W J Huizinga,
A H M van der Helm-van Mil

Ann Rheum Dis Published Online First: 9 May 2013 doi:10.1136/annrheumdis-2013-203402

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Basic and translational research: Concise Report: The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis

L G M van Baarsen,
M J H de Hair,
T H Ramwadhdoebe,
IJ A J Zijlstra,
M Maas,
D M Gerlag,
P P Tak

Ann Rheum Dis Published Online First: 9 May 2013 doi:10.1136/annrheumdis-2012-202990

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Basic and translational research: Extended Report: Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis

Michal Tomcik,
Pawel Zerr,
Jana Pitkowski,
Katrin Palumbo-Zerr,
Jérôme Avouac,
Oliver Distler,
Radim Becvar,
Ladislav Senolt,
Georg Schett,
Jörg H Distler

Ann Rheum Dis Published Online First: 9 May 2013 doi:10.1136/annrheumdis-2012-203095

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Clinical and epidemiological research: Extended Report: Periarticular and generalised bone loss in patients with early rheumatoid arthritis: influence of alendronate and intra-articular glucocorticoid treatment. Post hoc analyses from the CIMESTRA trial

T W Jensen,
M S Hansen,
K Hørslev-Petersen,
L Hyldstrup,
B Abrahamsen,
B Langdahl,
B Zerahn,
J Pødenphant,
K Stengaard-Petersen,
P Junker,
M Østergaard,
T Lottenburger,
T Ellingsen,
L S Andersen,
I Hansen,
H Skjødt,
J K Pedersen,
U B Lauridsen,
A J Svendsen,
U Tarp,
H Lindegaard,
Anne Grethe Jurik,
Aage Vestergaard,
M L Hetland

Ann Rheum Dis Published Online First: 9 May 2013 doi:10.1136/annrheumdis-2012-203171

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5 May 2013

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Clinical and epidemiological research: Concise Report: The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSRBR-RA

Jakub Závada,
Mark Lunt,
Rebecca Davies,
Audrey SL Low,
Louise K Mercer,
James B Galloway,
Kath D Watson,
Deborah P Symmons,
Kimme L Hyrich

Ann Rheum Dis Published Online First: 5 May 2013 doi:10.1136/annrheumdis-2012-203102

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Clinical and epidemiological research: Extended Report: Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus

Ben Parker,
Awal Al-Husain,
Philip Pemberton,
Allen P Yates,
Pauline Ho,
Rachel Gorodkin,
Lee Suan Teh,
M Yvonne Alexander,
Ian N Bruce

Ann Rheum Dis Published Online First: 5 May 2013 doi:10.1136/annrheumdis-2012-203028

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3 May 2013

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Clinical and epidemiological research: Extended Report: High prevalence of anti-CD74 antibodies specific for the HLA class II-associated invariant chain peptide (CLIP) in patients with axial spondyloarthritis

X Baraliakos,
N Baerlecken,
T Witte,
F Heldmann,
J Braun

Ann Rheum Dis Published Online First: 3 May 2013 doi:10.1136/annrheumdis-2012-202177

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Basic and translational research: Extended Report: Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis

Fanlei Hu,
Rong Mu,
Jiaxin Zhu,
Lianjie Shi,
Yingni Li,
Xu Liu,
Wenwei Shao,
Guiye Li,
Minghui Li,
Yin Su,
Philip L Cohen,
Xiaoyan Qiu,
Zhanguo Li

Ann Rheum Dis Published Online First: 3 May 2013 doi:10.1136/annrheumdis-2012-202444

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Clinical and epidemiological research: Concise Report: Correlations between nailfold microangiopathy severity, finger dermal thickness and fingertip blood perfusion in systemic sclerosis patients

A Sulli,
B Ruaro,
E Alessandri,
C Pizzorni,
M A Cimmino,
G Zampogna,
M Gallo,
M Cutolo

Ann Rheum Dis Published Online First: 3 May 2013 doi:10.1136/annrheumdis-2012-202572

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Clinical and epidemiological research: Extended report: The effect of two golimumab doses on radiographic progression in ankylosing spondylitis: results through 4 years of the GO-RAISE trial

Jürgen Braun,
Xenofon Baraliakos,
Kay-Geert A Hermann,
Atul Deodhar,
Désirée van der Heijde,
Robert Inman,
Anna Beutler,
Yiying Zhou,
Stephen Xu,
Benjamin Hsu

Ann Rheum Dis Published Online First: 3 May 2013 doi:10.1136/annrheumdis-2012-203075

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1 May 2013

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Clinical and epidemiological research: Extended report: The fibrin-derived citrullinated peptide β60–74Cit_60,72,74 bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies

M Cornillet,
M Sebbag,
E Verrouil,
A Magyar,
F Babos,
A Ruyssen-Witrand,
F Hudecz,
A Cantagrel,
G Serre,
L Nogueira

Ann Rheum Dis Published Online First: 1 May 2013 doi:10.1136/annrheumdis-2012-202868

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Clinical and epidemiological research: Extended report: Whole-body MRI in the assessment of disease activity in juvenile dermatomyositis

Clara Malattia,
Maria Beatrice Damasio,
Annalisa Madeo,
Angela Pistorio,
Anna Providenti,
Silvia Pederzoli,
Stefania Viola,
Antonella Buoncompagni,
Chiara Mattiuz,
Agnese Beltramo,
Alessandro Consolaro,
Angelo Ravelli,
Nicolino Ruperto,
Paolo Picco,
Gian Michele Magnano,
Alberto Martini

Ann Rheum Dis Published Online First: 1 May 2013 doi:10.1136/annrheumdis-2012-202915

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30 April 2013

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Basic and translational research: Extended Report: Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis

Gisela Ruiz-Heiland,
Yi Zhao,
Anja Derer,
Tobias Braun,
Klaus Engelke,
Elena Neumann,
Ulf Mueller-Ladner,
Yi Liu,
Jochen Zwerina,
Georg Schett

Ann Rheum Dis Published Online First: 30 April 2013 doi:10.1136/annrheumdis-2012-202907

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27 April 2013

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Basic and translational research: Extended report: Changes in biomarkers after therapeutic intervention in temporal arteries cultured in Matrigel: a new model for preclinical studies in giant-cell arteritis

Marc Corbera-Bellalta,
Ana García-Martínez,
Ester Lozano,
Ester Planas-Rigol,
Itziar Tavera-Bahillo,
Marco A Alba,
Sergio Prieto-González,
Montserrat Butjosa,
Georgina Espígol-Frigolé,
José Hernández-Rodríguez,
Pedro L Fernández,
Pascale Roux-Lombard,
Jean-Michel Dayer,
Mahboob U Rahman,
Maria C Cid

Ann Rheum Dis Published Online First: 27 April 2013 doi:10.1136/annrheumdis-2012-202883

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26 April 2013

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Basic and translational research: Extended report: Anakinra treatment in patients with refractory inflammatory myopathies and possible predictive response biomarkers: a mechanistic study with 12 months follow-up

Mei Zong,
Christina Dorph,
Maryam Dastmalchi,
Helene Alexanderson,
Jennifer Pieper,
Petra Amoudruz,
Sevim Barbasso Helmers,
Inger Nennesmo,
Vivianne Malmström,
Ingrid E Lundberg

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2012-202857

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Clinical and epidemiological research: Extended report: Osteitis and synovitis, but not bone erosion, is associated with proteoglycan loss and microstructure damage in the cartilage of patients with rheumatoid arthritis

Barbara Herz,
Andreas Albrecht,
Matthias Englbrecht,
Götz H Welsch,
Michael Uder,
Nina Renner,
Philipp Schlechtweg,
Dominik Paul,
Lars Lauer,
Klaus Engelke,
Rolf Janka,
Jürgen Rech,
Georg Schett,
Stephanie Finzel

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2012-202850

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Letter: Cigarette smoking has a dose-dependent impact on progression of structural damage in the spine in patients with axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort (GESPIC)

Denis Poddubnyy,
Hildrun Haibel,
Joachim Listing,
Elisabeth Märker-Hermann,
Henning Zeidler,
Jürgen Braun,
Joachim Sieper,
Martin Rudwaleit

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2012-203148

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Basic and translational research: Extended report: Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply

Kirsty McHugh,
Oliwia Rysnik,
Simon Kollnberger,
Jacqueline Shaw,
Lotta Utriainen,
Mohammad Hussein Al-Mossawi,
Sravan Payeli,
Osiris Marroquin,
Simon Milling,
Christoph Renner,
Paul Bowness

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2012-203080

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Editorial: Novel targeted therapies: the future of rheumatoid arthritis? Mavrilumab and tabalumab as examples

Bernard Combe,
Ronald van Vollenhoven

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2013-203261

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Basic and translational research: Extended report: Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice—a translational model for atherosclerosis

L M Gierman,
S Kühnast,
A Koudijs,
E J Pieterman,
M Kloppenburg,
G J V M van Osch,
V Stojanovic-Susulic,
T W J Huizinga,
H M G Princen,
A-M Zuurmond

Ann Rheum Dis Published Online First: 26 April 2013 doi:10.1136/annrheumdis-2013-203248

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25 April 2013

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Clinical and epidemiological research: Extended report: Tumour necrosis factor α blockers are more effective than methotrexate in the inhibition of radiographic joint damage progression among patients with psoriatic arthritis

Lihi Eder,
Arane Thavaneswaran,
Vinod Chandran,
Dafna D Gladman

Ann Rheum Dis Published Online First: 25 April 2013 doi:10.1136/annrheumdis-2012-202959

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Basic and translational research: Extended report: Peripheral joint inflammation in early onset spondyloarthritis is not specifically related to enthesitis

Jacqueline E Paramarta,
Christiaan van der Leij,
Ioana Gofita,
Nataliya Yeremenko,
Marleen G van de Sande,
Maria J de Hair,
Paul P Tak,
Mario Maas,
Dominique Baeten

Ann Rheum Dis Published Online First: 25 April 2013 doi:10.1136/annrheumdis-2012-203155

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23 April 2013

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Clinical and epidemiological research: Extended report: Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study

Camilla Bengtsson,
Leonid Padyukov,
Henrik Källberg,
Saedis Saevarsdottir

Ann Rheum Dis Published Online First: 23 April 2013 doi:10.1136/annrheumdis-2013-203354

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20 April 2013

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Clinical and epidemiological research: Extended report: Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24

David Saadoun,
M Resche Rigon,
V Thibault,
M Longuet,
S Pol,
F Blanc,
G Pialoux,
A Karras,
D Bazin-Karra,
C Cazorla,
D Vittecoq,
L Musset,
O Decaux,
J M Ziza,
O Lambotte,
Patrice Cacoub

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2012-202770

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Basic and translational research: Extended report: Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity

M E Doorenspleet,
P L Klarenbeek,
M J H de Hair,
B D C van Schaik,
R E E Esveldt,
A H C van Kampen,
D M Gerlag,
A Musters,
F Baas,
P P Tak,
N de Vries

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2012-202861

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Clinical and epidemiological research: Extended report: Genetic associations to germinal centre formation in primary Sjögren's syndrome

Tove Ragna Reksten,
Svein Joar Auglænd Johnsen,
Malin Viktoria Jonsson,
Roald Omdal,
Johan G Brun,
Elke Theander,
Per Eriksson,
Marie Wahren-Herlenius,
Roland Jonsson,
Gunnel Nordmark

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2012-202500

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Clinical and epidemiological research: Extended report: The degree of skin involvement identifies distinct lung disease outcomes and survival in systemic sclerosis

Tricia R Cottrell,
Robert A Wise,
Fredrick M Wigley,
Francesco Boin

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2012-202849

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Clinical and epidemiological research: Extended report: Measurement error in the assessment of radiographic progression in rheumatoid arthritis (RA) clinical trials: the smallest detectable change (SDC) revisited

V Navarro-Compán,
D van der Heijde,
Harris A Ahmad,
Colin G Miller,
R Wolterbeek,
R Landewé

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2012-202939

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Review: Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group?

Arnaud Millet,
Magali Pederzoli-Ribeil,
Loïc Guillevin,
Véronique Witko-Sarsat,
Luc Mouthon

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2013-203255

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Letter: Abatacept in relapsing polychondritis

Stanford L Peng,
Donald Rodriguez

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2013-203319

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Clinical and epidemiological research: Extended report: The risk of atrial fibrillation in patients with rheumatoid arthritis

Seoyoung C Kim,
Jun Liu,
Daniel H Solomon

Ann Rheum Dis Published Online First: 20 April 2013 doi:10.1136/annrheumdis-2013-203343

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18 April 2013

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Clinical and epidemiological research: Concise report: VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis

Valerie Nell-Duxneuner,
Roland Axmann,
Emma Husar-Memmer,
Tomáš Dallos,
Christian Datz,
Andreas Stadlmayr,
Elmar Aigner,
Matthias Englbrecht,
Georg Schett,
Jochen Zwerina

Ann Rheum Dis Published Online First: 18 April 2013 doi:10.1136/annrheumdis-2012-202800

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Clinical and epidemiological research: Extended report: A phase 2 dose-ranging study of subcutaneous tabalumab for the treatment of patients with active rheumatoid arthritis and an inadequate response to methotrexate

Mark C Genovese,
Eric Lee,
Julie Satterwhite,
Melissa Veenhuizen,
Damon Disch,
Pierre-Yves Berclaz,
Stephen Myers,
Gregory Sides,
Olivier Benichou

Ann Rheum Dis Published Online First: 18 April 2013 doi:10.1136/annrheumdis-2012-202864

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Letter: Investigation of C reactive protein gene polymorphisms as predictors of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register

Ibrahim Ibrahim,
Darren Plant,
Mark Lunt,
Suzanne Verstappen,
Edward Flynn,
Deborah Symmons,
Anne Barton

Ann Rheum Dis Published Online First: 18 April 2013 doi:10.1136/annrheumdis-2012-202920

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Clinical and epidemiological research: Extended report: Safety profile of protein kinase inhibitors in rheumatoid arthritis: systematic review and meta-analysis

Eva Salgado,
Jose R Maneiro,
Loreto Carmona,
Juan J Gomez-Reino

Ann Rheum Dis Published Online First: 18 April 2013 doi:10.1136/annrheumdis-2012-203116

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17 April 2013

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Clinical and epidemiological research: Extended report: Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study

Laura L Laslett,
Stephen Quinn,
John R Burgess,
Venkateswaran Parameswaran,
Tania M Winzenberg,
Graeme Jones,
Changhai Ding

Ann Rheum Dis Published Online First: 17 April 2013 doi:10.1136/annrheumdis-2012-202831

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16 April 2013

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Clinical and epidemiological research: Extended report: Genetics of toll like receptor 9 in ANCA associated vasculitides

C A Husmann,
J U Holle,
F Moosig,
S Mueller,
B Wilde,
J W Cohen Tervaert,
L Harper,
G Assmann,
W L Gross,
J T Epplen,
S Wieczorek

Ann Rheum Dis Published Online First: 16 April 2013 doi:10.1136/annrheumdis-2012-202803

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Clinical and epidemiological research: Extended report: Performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: a systematic literature review

Helga Radner,
Tuhina Neogi,
Josef S Smolen,
Daniel Aletaha

Ann Rheum Dis Published Online First: 16 April 2013 doi:10.1136/annrheumdis-2013-203284

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12 April 2013

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Clinical and epidemiological research: Extended report: Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative

Laura L Laslett,
Sarah R Kingsbury,
Elizabeth M A Hensor,
Michael A Bowes,
Philip G Conaghan

Ann Rheum Dis Published Online First: 12 April 2013 doi:10.1136/annrheumdis-2012-202989

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10 April 2013

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Clinical and epidemiological research: Extended report: The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women

Carrie A Karvonen-Gutierrez,
Siobán D Harlow,
Jon Jacobson,
Peter Mancuso,
Yebin Jiang

Ann Rheum Dis Published Online First: 10 April 2013 doi:10.1136/annrheumdis-2012-202685

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9 April 2013

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Clinical and epidemiological research: Concise report: Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA

Ryan W Gan,
Kevin D Deane,
Gary O Zerbe,
M Kristen Demoruelle,
Michael H Weisman,
Jane H Buckner,
Peter K Gregersen,
Ted R Mikuls,
James R O'Dell,
Richard M Keating,
V Michael Holers,
Jill M Norris

Ann Rheum Dis Published Online First: 9 April 2013 doi:10.1136/annrheumdis-2012-202949

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Clinical and epidemiological research: Extended report: What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review

J A B van Nies,
A Krabben,
J W Schoones,
T W J Huizinga,
M Kloppenburg,
A H M van der Helm-van Mil

Ann Rheum Dis Published Online First: 9 April 2013 doi:10.1136/annrheumdis-2012-203130

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Letter: Increased plasma levels of the VEGF₁₆₅b splice variant are associated with the severity of nailfold capillary loss in systemic sclerosis

Mirko Manetti,
Serena Guiducci,
Eloisa Romano,
Silvia Bellando-Randone,
Gemma Lepri,
Cosimo Bruni,
Maria Letizia Conforti,
Lidia Ibba-Manneschi,
Marco Matucci-Cerinic

Ann Rheum Dis Published Online First: 9 April 2013 doi:10.1136/annrheumdis-2012-203183

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5 April 2013

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Clinical and epidemiological research: Concise report: Switching between TNF inhibitors in psoriatic arthritis: data from the NOR-DMARD study

Karen Minde Fagerli,
Elisabeth Lie,
Désirée van der Heijde,
Marte Schrumpf Heiberg,
Synøve Kalstad,
Erik Rødevand,
Knut Mikkelsen,
Åse Stavland Lexberg,
Tore K Kvien

Ann Rheum Dis Published Online First: 5 April 2013 doi:10.1136/annrheumdis-2012-203018

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Basic and translational research: Extended report: Impaired serum cholesterol efflux capacity in rheumatoid arthritis and systemic lupus erythematosus

Nicoletta Ronda,
Elda Favari,
Maria Orietta Borghi,
Francesca Ingegnoli,
Maria Gerosa,
Cecilia Chighizola,
Francesca Zimetti,
Maria Pia Adorni,
Franco Bernini,
Pier Luigi Meroni

Ann Rheum Dis Published Online First: 5 April 2013 doi:10.1136/annrheumdis-2012-202914

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3 April 2013

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Clinical and epidemiological research: Extended report: Association between testosterone levels and risk of future rheumatoid arthritis in men: a population-based case–control study

Mitra Pikwer,
Aleksander Giwercman,
Ulf Bergström,
Jan-Åke Nilsson,
Lennart T H Jacobsson,
Carl Turesson

Ann Rheum Dis Published Online First: 3 April 2013 doi:10.1136/annrheumdis-2012-202781

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28 March 2013

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Basic and translational research: Extended report: Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

Anne-Marie Quirke,
Elena Birgitta Lugli,
Natalia Wegner,
Bart C Hamilton,
Peter Charles,
Muslima Chowdhury,
A Jimmy Ytterberg,
Roman A Zubarev,
Jan Potempa,
Shauna Culshaw,
Yonghua Guo,
Benjamin A Fisher,
Geoffrey Thiele,
Ted R Mikuls,
Patrick JW Venables

Ann Rheum Dis Published Online First: 5 March 2013 doi:10.1136/annrheumdis-2012-202726

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27 March 2013

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Clinical and epidemiological research: Extended report: Continuous long-term anti-TNF therapy does not lead to an increase in the rate of new bone formation over 8 years in patients with ankylosing spondylitis

Xenofon Baraliakos,
Hildrun Haibel,
Joachim Listing,
Joachim Sieper,
Jürgen Braun

Ann Rheum Dis Published Online First: 16 March 2013 doi:10.1136/annrheumdis-2012-202698

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26 March 2013

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Clinical and epidemiological research: Concise report: Extent and distribution of CPP deposits in patients affected by calcium pyrophosphate dihydrate deposition disease: an ultrasonographic study

Georgios Filippou,
Emilio Filippucci,
Marika Tardella,
Ilaria Bertoldi,
Marco Di Carlo,
Antonella Adinolfi,
Walter Grassi,
Bruno Frediani

Ann Rheum Dis Published Online First: 26 March 2013 doi:10.1136/annrheumdis-2012-202748

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Clinical and epidemiological research: Extended report: Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease

Benjamin A Fisher,
So-Young Bang,
Muslima Chowdhury,
Hye-Soon Lee,
Jae-Hoon Kim,
Peter Charles,
Patrick Venables,
Sang-Cheol Bae

Ann Rheum Dis Published Online First: 16 March 2013 doi:10.1136/annrheumdis-2012-202535

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22 March 2013

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Clinical and epidemiological research: Extended report: Improvements in health-related quality of life with belimumab, a B-lymphocyte stimulator-specific inhibitor, in patients with autoantibody-positive systemic lupus erythematosus from the randomised controlled BLISS trials

Vibeke Strand,
Roger A Levy,
Ricard Cervera,
Michelle A Petri,
Helen Birch,
William W Freimuth,
Z John Zhong,
Ann E Clarke

Ann Rheum Dis Published Online First: 22 March 2013 doi:10.1136/annrheumdis-2012-202865

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21 March 2013

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Clinical and epidemiological research: Extended report: Predictors of work disability during the first 3 years after diagnosis in a national rheumatoid arthritis inception cohort

Tor Olofsson,
Ingemar F Petersson,
Jonas K Eriksson,
Martin Englund,
Julia F Simard,
Jan-Åke Nilsson,
Pierre Geborek,
Lennart T H Jacobsson,
Johan Askling,
Martin Neovius

Ann Rheum Dis Published Online First: 21 March 2013 doi:10.1136/annrheumdis-2012-202911

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Clinical and epidemiological research: Extended report: Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies

Arnd Kleyer,
Stephanie Finzel,
Jürgen Rech,
Bernhard Manger,
Manuel Krieter,
Francesca Faustini,
Elisabeth Araujo,
Axel J Hueber,
Ulrike Harre,
Klaus Engelke,
Georg Schett

Ann Rheum Dis Published Online First: 21 March 2013 doi:10.1136/annrheumdis-2012-202958

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20 March 2013

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Basic and translational research: Extended report: A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses

Jun Wei,
Hongyan Zhu,
Kazuhiro Komura,
Gabriel Lord,
Michal Tomcik,
Wenxia Wang,
Sruthi Doniparthi,
Zenshiro Tamaki,
Monique Hinchcliff,
Joerg H W Distler,
John Varga

Ann Rheum Dis Published Online First: 20 March 2013 doi:10.1136/annrheumdis-2012-202716

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19 March 2013

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Basic and translational research: Extended report: Ochronotic osteoarthropathy in a mouse model of alkaptonuria, and its inhibition by nitisinone

Andrew J Preston,
Craig M Keenan,
Hazel Sutherland,
Peter J Wilson,
Brenda Wlodarski,
Adam M Taylor,
Dominic P Williams,
Lakshminarayan R Ranganath,
James A Gallagher,
Jonathan C Jarvis

Ann Rheum Dis Published Online First: 19 March 2013 doi:10.1136/annrheumdis-2012-202878

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Basic and translational research: Extended report: The enhanced liver fibrosis test: a clinical grade, validated serum test, biomarker of overall fibrosis in systemic sclerosis

Giuseppina Abignano,
Giovanna Cuomo,
Maya H Buch,
William M Rosenberg,
Gabriele Valentini,
Paul Emery,
Francesco Del Galdo

Ann Rheum Dis Published Online First: 19 March 2013 doi:10.1136/annrheumdis-2012-202843

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Clinical and epidemiological research: Extended report: N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) and mortality risk in early inflammatory polyarthritis: results from the Norfolk Arthritis Registry (NOAR)

Hoda Mirjafari,
Paul Welsh,
Suzanne M M Verstappen,
Paddy Wilson,
Tarnya Marshall,
Helena Edlin,
Diane Bunn,
Jacqueline Chipping,
Mark Lunt,
Deborah P M Symmons,
Naveed Sattar,
Ian N Bruce

Ann Rheum Dis Published Online First: 19 March 2013 doi:10.1136/annrheumdis-2012-202848

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13 March 2013

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Basic and translational research: Extended report: Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis

Beatriz Orosa,
Samuel García,
Paula Martínez,
Antonio González,
Juan J Gómez-Reino,
Carmen Conde

Ann Rheum Dis Published Online First: 13 March 2013 doi:10.1136/annrheumdis-2012-202832

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12 March 2013

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Clinical and epidemiological research: Extended report: Open-label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study*

Iain B McInnes,
Ho-Youn Kim,
Sang-Heon Lee,
David Mandel,
Yeong-Wook Song,
Carol A Connell,
Zhen Luo,
M Julia Brosnan,
Andrea Zuckerman,
Samuel H Zwillich,
John D Bradley

Ann Rheum Dis Published Online First: 12 March 2013 doi:10.1136/annrheumdis-2012-202442

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8 March 2013

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Clinical and epidemiological research: Extended report: Efficacy and safety of adalimumab in Chinese adults with active ankylosing spondylitis: results of a randomised, controlled trial

Feng Huang,
Jieruo Gu,
Ping Zhu,
Chunde Bao,
Jianhua Xu,
Huji Xu,
Huaxiang Wu,
Guochun Wang,
Qun Shi,
Nupun Andhivarothai,
Jaclyn Anderson,
Aileen L Pangan

Ann Rheum Dis Published Online First: 8 March 2013 doi:10.1136/annrheumdis-2012-202533

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Clinical and epidemiological research: Extended report: Ultrasound colour Doppler is associated with synovial pathology in biopsies from hand joints in rheumatoid arthritis patients: a cross-sectional study

Martin Andersen,
Karen Ellegaard,
Josephine B Hebsgaard,
Robin Christensen,
Søren Torp-Pedersen,
Peter H Kvist,
Niels Søe,
John Rømer,
Nina Vendel,
Else Marie Bartels,
Bente Danneskiold-Samsøe,
Henning Bliddal

Ann Rheum Dis Published Online First: 8 March 2013 doi:10.1136/annrheumdis-2012-202669

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Basic and translational research: Extended report: Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response

Philipp Enghard,
Claudia Rieder,
Katharina Kopetschke,
J R Klocke,
Reinmar Undeutsch,
Robert Biesen,
Duska Dragun,
Maik Gollasch,
Udo Schneider,
Karlfried Aupperle,
Jens Y Humrich,
Falk Hiepe,
Marina Backhaus,
A H Radbruch,
Gerd R Burmester,
Gabriela Riemekasten

Ann Rheum Dis Published Online First: 8 March 2013 doi:10.1136/annrheumdis-2012-202784

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7 March 2013

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Clinical and epidemiological research: Extended report: Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial

Kim Hørslev-Petersen,
Merete Lund Hetland,
Peter Junker,
Jan Pødenphant,
Torkell Ellingsen,
Palle Ahlquist,
Hanne Lindegaard,
Asta Linauskas,
Annette Schlemmer,
Mette Yde Dam,
Ib Hansen,
Hans Christian Horn,
Christian Gytz Ammitzbøll,
Anette Jørgensen,
Sophine B Krintel,
Johnny Raun,
Julia S Johansen,
Mikkel Østergaard,
Kristian Stengaard-Pedersen

Ann Rheum Dis Published Online First: 23 February 2013 doi:10.1136/annrheumdis-2012-202735

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6 March 2013

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Clinical and epidemiological research: Extended report: Inequities in access to biologic and synthetic DMARDs across 46 European countries

Polina Putrik,
Sofia Ramiro,
Tore K Kvien,
Tuulikki Sokka,
Milena Pavlova,
Till Uhlig,
Annelies Boonen,
Working Group ‘Equity in access to treatment of rheumatoid arthritis in Europe’

Ann Rheum Dis Published Online First: 6 March 2013 doi:10.1136/annrheumdis-2012-202603

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5 March 2013

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Clinical and epidemiological research: Extended report: Results from a multicentre international registry of familial Mediterranean fever: impact of environment on the expression of a monogenic disease in children

Seza Ozen,
Erkan Demirkaya,
Gayane Amaryan,
Isabelle Koné-Paut,
Adem Polat,
Pat Woo,
Yosef Uziel,
Consuelo Modesto,
Martina Finetti,
Pierre Quartier,
Efimia Papadopoulou-Alataki,
Sulaiman M Al-Mayouf,
Giovanna Fabio,
Romina Gallizzi,
Luca Cantarini,
Joost Frenkel,
Susan Nielsen,
Michael Hofer,
Antonella Insalaco,
C Acikel,
Huri Ozdogan,
Alberto Martini,
Nicolino Ruperto,
Marco Gattorno

Ann Rheum Dis Published Online First: 5 March 2013 doi:10.1136/annrheumdis-2012-202708

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Basic and translational research: Extended report: Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis

Parawee Suwannalai,
Karin Britsemmer,
Rachel Knevel,
Hans Ulrich Scherer,
E W Nivine Levarht,
Annette H van der Helm-van Mil,
Dirkjan van Schaardenburg,
Tom W J Huizinga,
René E M Toes,
L A Trouw

Ann Rheum Dis Published Online First: 5 March 2013 doi:10.1136/annrheumdis-2012-202615

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26 February 2013

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Clinical and epidemiological research: Extended report: Patients with non-Jo-1 anti-tRNA-synthetase autoantibodies have worse survival than Jo-1 positive patients

Rohit Aggarwal,
Elaine Cassidy,
Noreen Fertig,
Diane Carol Koontz,
Mary Lucas,
Dana P Ascherman,
Chester V Oddis

Ann Rheum Dis Published Online First: 19 February 2013 doi:10.1136/annrheumdis-2012-201800

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Basic and translational research: Extended report: New insight on the Xq28 association with systemic sclerosis

F David Carmona,
M Carmen Cénit,
Lina-Marcela Diaz-Gallo,
Jasper C A Broen,
Carmen P Simeón,
Patricia E Carreira,
José-Luis Callejas-Rubio,
Vicente Fonollosa,
Francisco J López-Longo,
Miguel A González-Gay,
Nicolas Hunzelmann,
Gabriela Riemekasten,
Torsten Witte,
Alexander Kreuter,
Jörg H W Distler,
Rajan Madhok,
Paul Shiels,
Jacob M van Laar,
Annemie J Schuerwegh,
Madelon C Vonk,
Alexandre E Voskuyl,
Carmen Fonseca,
Christopher P Denton,
Ariane Herrick,
Jane Worthington,
Frank C Arnett,
Filemon K Tan,
Shervin Assassi,
Timothy R D J Radstake,
Maureen D Mayes,
Javier Martín

Ann Rheum Dis Published Online First: 26 February 2013 doi:10.1136/annrheumdis-2012-202742

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25 February 2013

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Clinical and epidemiological research: Extended report: Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behçet's disease

Yun Jong Lee,
Yukihiro Horie,
Graham R Wallace,
Yong Seok Choi,
Ji Ah Park,
Ji Yong Choi,
Ran Song,
Young-Mo Kang,
Seong Wook Kang,
Han Joo Baek,
Nobuyoshi Kitaichi,
Akira Meguro,
Nobuhisa Mizuki,
Kenichi Namba,
Susumu Ishida,
Jinhyun Kim,
Edyta Niemczyk,
Eun Young Lee,
Yeong Wook Song,
Shigeaki Ohno,
Eun Bong Lee

Ann Rheum Dis Published Online First: 6 October 2012 doi:10.1136/annrheumdis-2011-200288

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23 February 2013

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Clinical and epidemiological research: Extended report: Clustering of hand osteoarthritis progression and its relationship to progression of osteoarthritis at the knee

Jessica Bijsterbosch,
Ingrid Meulenbelt,
Iain Watt,
Frits R Rosendaal,
Tom W J Huizinga,
Margreet Kloppenburg

Ann Rheum Dis Published Online First: 23 February 2013 doi:10.1136/annrheumdis-2012-202461

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Basic and translational research: Extended report: A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients

Brandon W Higgs,
Wei Zhu,
Chris Morehouse,
Wendy I White,
Philip Brohawn,
Xiang Guo,
Marlon Rebelatto,
Chenxiong Le,
Anthony Amato,
David Fiorentino,
Steven A Greenberg,
Jorn Drappa,
Laura Richman,
Warren Greth,
Bahija Jallal,
Yihong Yao

Ann Rheum Dis Published Online First: 23 February 2013 doi:10.1136/annrheumdis-2012-202794

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Basic and translational research: Extended report: The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release

Darren Lee Asquith,
Lucy E Ballantine,
Jagtar Singh Nijjar,
Manhal Khuder Makdasy,
Sabina Patel,
Pamela B Wright,
James H Reilly,
Shauna Kerr,
Mariola Kurowska-Stolarska,
J Alastair Gracie,
Iain B McInnes

Ann Rheum Dis Published Online First: 23 February 2013 doi:10.1136/annrheumdis-2012-202872

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22 February 2013

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Clinical and epidemiological research: Extended report: Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein

Stacy P Ardoin,
Laura Eve Schanberg,
Christy I Sandborg,
Huiman X Barnhart,
Greg W Evans,
Eric Yow,
Kelly L Mieszkalski,
Norman T Ilowite,
Anne Eberhard,
Lisa F Imundo,
Yuki Kimura,
Deborah Levy,
Emily von Scheven,
Earl Silverman,
Suzanne L Bowyer,
L Punaro,
Nora G Singer,
David D Sherry,
Deborah K McCurdy,
Marissa Klein-Gitelman,
Carol Wallace,
Richard M Silver,
Linda Wagner-Weiner,
Gloria C Higgins,
Hermine I Brunner,
Lawrence Jung,
Jennifer B Soep,
Ann M Reed,
Susan D Thompson

Ann Rheum Dis Published Online First: 22 February 2013 doi:10.1136/annrheumdis-2012-202315

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20 February 2013

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Basic and translational research: Extended report: Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

Giuseppina Abignano,
Sibel Zehra Aydin,
Concepción Castillo-Gallego,
Vasiliki Liakouli,
Daniel Woods,
Adam Meekings,
Richard J Wakefield,
Dennis G McGonagle,
Paul Emery,
Francesco Del Galdo

Ann Rheum Dis Published Online First: 20 February 2013 doi:10.1136/annrheumdis-2012-202682

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Clinical and epidemiological research: Concise report: Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud's phenomenon: systematic review and meta-analysis of randomised trials

Matthieu Roustit,
Sophie Blaise,
Yannick Allanore,
Patrick H Carpentier,
Evren Caglayan,
Jean-Luc Cracowski

Ann Rheum Dis Published Online First: 20 February 2013 doi:10.1136/annrheumdis-2012-202836

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Clinical and epidemiological research: Extended report: Expert consensus for performing right heart catheterisation for suspected pulmonary arterial hypertension in systemic sclerosis: a Delphi consensus study with cluster analysis

Jérôme Avouac,
Dörte Huscher,
Daniel E Furst,
Christian F Opitz,
Oliver Distler,
Yannick Allanore

Ann Rheum Dis Published Online First: 24 January 2013 doi:10.1136/annrheumdis-2012-202567

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16 February 2013

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Basic and translational research: Extended report: Regulation of matrixmetalloproteinase-3 and matrixmetalloproteinase-13 by SUMO-2/3 through the transcription factor NF-κB

Svetlana Frank,
Marvin A Peters,
Corinna Wehmeyer,
Simon Strietholt,
Christina Koers-Wunrau,
Jessica Bertrand,
Marianne Heitzmann,
Anja Hillmann,
Joanna Sherwood,
Christine Seyfert,
Steffen Gay,
Thomas Pap

Ann Rheum Dis Published Online First: 16 February 2013 doi:10.1136/annrheumdis-2012-202080

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15 February 2013

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Basic and translational research: Extended report: NKG₂D stimulated T-cell autoreactivity in giant cell arteritis and polymyalgia rheumatica

Christian Dejaco,
Christina Duftner,
Juman Al-Massad,
Annette D Wagner,
Joon-Keun Park,
Johannes Fessler,
Ariane Aigelsreiter,
Franz Hafner,
Sandra Vega,
William Sterlacci,
Beatrix Grubeck-Loebenstein,
Alexander Tzankov,
Thomas Ness,
Luigi Boiardi,
Carlo Salvarani,
Michael Schirmer

Ann Rheum Dis Published Online First: 15 February 2013 doi:10.1136/annrheumdis-2012-201660

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14 February 2013

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Clinical and epidemiological research: Extended report: Measurement invariance of the Illness Invalidation Inventory (3*I) across language, rheumatic disease and gender

Marianne Belia Kool,
Rens van de Schoot,
Isabel López-Chicheri García,
Ricarda Mewes,
José A P Da Silva,
Karoline Vangronsveld,
Andreas A J Wismeijer,
Mark A Lumley,
Henriët van Middendorp,
Johannes W J Bijlsma,
Geert Crombez,
Winfried Rief,
Rinie Geenen

Ann Rheum Dis Published Online First: 14 February 2013 doi:10.1136/annrheumdis-2012-201807

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Basic and translational research: Extended report: A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis

Alicia Usategui,
Gabriel Criado,
Elena Izquierdo,
Manuel J Del Rey,
Patricia E Carreira,
Pablo Ortiz,
Warren J Leonard,
José L Pablos

Ann Rheum Dis Published Online First: 14 February 2013 doi:10.1136/annrheumdis-2012-202279

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9 February 2013

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Basic and translational research: Extended report: Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration

Kate Louise Eve Phillips,
Nikki Jordan-Mahy,
Martin J H Nicklin,
Christine Lyn Le Maitre

Ann Rheum Dis Published Online First: 9 February 2013 doi:10.1136/annrheumdis-2012-202266

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8 February 2013

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Clinical and epidemiological research: Concise report: The multifaceted clinical presentations and manifestations of Erdheim–Chester disease: comprehensive review of the literature and of 10 new cases

Giulio Cavalli,
Barbara Guglielmi,
Alvise Berti,
Corrado Campochiaro,
Maria Grazia Sabbadini,
Lorenzo Dagna

Ann Rheum Dis Published Online First: 8 February 2013 doi:10.1136/annrheumdis-2012-202542

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Clinical and epidemiological research: Concise report: MRI of hand and foot joints of patients with anticitrullinated peptide antibody positive arthralgia without clinical arthritis

Annemarie Krabben,
Wouter Stomp,
Désirée M F M van der Heijde,
Jessica A B van Nies,
Johan L Bloem,
Tom W J Huizinga,
Monique Reijnierse,
Annette H M van der Helm-van Mil

Ann Rheum Dis Published Online First: 19 January 2013 doi:10.1136/annrheumdis-2012-202628

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5 February 2013

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Clinical and epidemiological research: Extended report: Shared care or nursing consultations as an alternative to rheumatologist follow-up for rheumatoid arthritis outpatients with low disease activity—patient outcomes from a 2-year, randomised controlled trial

Jette Primdahl,
Jan Sørensen,
Hans Christian Horn,
Randi Petersen,
Kim Hørslev-Petersen

Ann Rheum Dis Published Online First: 5 February 2013 doi:10.1136/annrheumdis-2012-202695

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3 February 2013

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Clinical and epidemiological research: Extended report: Metric properties of advanced imaging methods in osteoarthritis of the hand: a systematic review

Michael S Saltzherr,
Ruud W Selles,
Sita M A Bierma-Zeinstra,
Galied S R Muradin,
J Henk Coert,
Johan W van Neck,
Jolanda J Luime

Ann Rheum Dis Published Online First: 24 January 2013 doi:10.1136/annrheumdis-2012-202515

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29 January 2013

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Clinical and epidemiological research: Concise report: Predictors of preterm birth in patients with mild systemic lupus erythematosus

Megan E B Clowse,
Daniel J Wallace,
Michael Weisman,
Andra James,
Lisa G Criscione-Schreiber,
David S Pisetsky

Ann Rheum Dis Published Online First: 29 January 2013 doi:10.1136/annrheumdis-2012-202449

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Clinical and epidemiological research: Extended report: Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial

Iain B McInnes,
Joachim Sieper,
Jürgen Braun,
Paul Emery,
Désirée van der Heijde,
John D Isaacs,
Georg Dahmen,
Jürgen Wollenhaupt,
Hendrik Schulze-Koops,
Joseph Kogan,
Shenglin Ma,
Martin M Schumacher,
Arthur P Bertolino,
Wolfgang Hueber,
Paul P Tak

Ann Rheum Dis Published Online First: 29 January 2013 doi:10.1136/annrheumdis-2012-202646

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26 January 2013

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Clinical and epidemiological research: Concise report: The genetic contribution to severe post-traumatic osteoarthritis

Ana M Valdes,
Sally A Doherty,
Kenneth R Muir,
Margaret Wheeler,
Rose A Maciewicz,
Weiya Zhang,
Michael Doherty

Ann Rheum Dis Published Online First: 26 January 2013 doi:10.1136/annrheumdis-2012-202562

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25 January 2013

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Clinical and epidemiological research: Extended report: Effect of tumour necrosis factor blockers on radiographic progression of psoriatic arthritis: a systematic review and meta-analysis of randomised controlled trials

Radjiv Goulabchand,
Gaël Mouterde,
Thomas Barnetche,
Cédric Lukas,
Jacques Morel,
Bernard Combe

Ann Rheum Dis Published Online First: 25 January 2013 doi:10.1136/annrheumdis-2012-202641

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Clinical and epidemiological research: Extended report: Early psoriatic arthritis: short symptom duration, male gender and preserved physical functioning at presentation predict favourable outcome at 5-year follow-up. Results from the Swedish Early Psoriatic Arthritis Register (SwePsA)

Elke Theander,
Tomas Husmark,
Gerd-Marie Alenius,
Per T Larsson,
Annika Teleman,
Mats Geijer,
Ulla R C Lindqvist

Ann Rheum Dis Published Online First: 25 January 2013 doi:10.1136/annrheumdis-2012-201972

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Clinical and epidemiological research: Extended report: The characterisation and determinants of quality of life in ANCA associated vasculitis

Neil Basu,
Andrew McClean,
Lorraine Harper,
Esther Nicole Amft,
Neeraj Dhaun,
Raashid A Luqmani,
Mark A Little,
David RW Jayne,
Oliver Flossmann,
John McLaren,
Vinod Kumar,
Lars P Erwig,
David M Reid,
Gareth T Jones,
Gary J Macfarlane

Ann Rheum Dis Published Online First: 25 January 2013 doi:10.1136/annrheumdis-2012-202750

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24 January 2013

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Basic and translational research: Extended report: Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load

Nicola Dalbeth,
Meaghan E House,
Gregory D Gamble,
Anne Horne,
Bregina Pool,
Lauren Purvis,
Angela Stewart,
Marilyn Merriman,
Murray Cadzow,
Amanda Phipps-Green,
Tony R Merriman

Ann Rheum Dis Published Online First: 24 January 2013 doi:10.1136/annrheumdis-2012-202732

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Basic and translational research: Extended report: Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes

Tejas S Lahoti,
Kaarthik John,
Jarod M Hughes,
Ann Kusnadi,
Iain A Murray,
Gowdahalli Krishnegowda,
Shantu Amin,
Gary H Perdew

Ann Rheum Dis Published Online First: 24 January 2013 doi:10.1136/annrheumdis-2012-202639

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Clinical and epidemiological research: Extended report: Chronological reading of radiographs in rheumatoid arthritis increases efficiency and does not lead to bias

Lilian H D van Tuyl,
Désirée van der Heijde,
Dirk L Knol,
Maarten Boers

Ann Rheum Dis Published Online First: 24 January 2013 doi:10.1136/annrheumdis-2012-202876

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23 January 2013

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Clinical and epidemiological research: Extended report: Randomised, controlled trial of avocado–soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study

Emmanuel Maheu,
Christian Cadet,
Marc Marty,
Dominique Moyse,
Isabelle Kerloch,
Philippe Coste,
Maxime Dougados,
Bernard Mazières,
Tim D Spector,
Hafid Halhol,
Jean-Marie Grouin,
Michel Lequesne

Ann Rheum Dis Published Online First: 23 January 2013 doi:10.1136/annrheumdis-2012-202485

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Clinical and epidemiological research: Extended report: International comparisons of the consultation prevalence of musculoskeletal conditions using population-based healthcare data from England and Sweden

Kelvin P Jordan,
Anna Jöud,
Charlotte Bergknut,
Peter Croft,
John J Edwards,
George Peat,
Ingemar F Petersson,
Aleksandra Turkiewicz,
Ross Wilkie,
Martin Englund

Ann Rheum Dis Published Online First: 23 January 2013 doi:10.1136/annrheumdis-2012-202634

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Clinical and epidemiological research: Concise report: Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy

Shunsuke Mori,
Yukitaka Ueki,
Yukihiro Akeda,
Naoyuki Hirakata,
Motohiro Oribe,
Yoshiki Shiohira,
Toshihiko Hidaka,
Kazunori Oishi

Ann Rheum Dis Published Online First: 23 January 2013 doi:10.1136/annrheumdis-2012-202658

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Clinical and epidemiological research: Extended report: Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus

Rina Mina,
Marisa S Klein-Gitelman,
Shannen Nelson,
B Anne Eberhard,
Gloria Higgins,
Nora G Singer,
Karen Onel,
Lori Tucker,
Kathleen M O'Neil,
Marilynn Punaro,
Deborah M Levy,
Kathleen Haines,
Alberto Martini,
Nicolino Ruperto,
Daniel Lovell,
Hermine I Brunner

Ann Rheum Dis Published Online First: 23 January 2013 doi:10.1136/annrheumdis-2012-202376

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Clinical and epidemiological research: Extended report: Quantitative measurement of syndesmophyte volume and height in ankylosing spondylitis using CT

Sovira Tan,
Jianhua Yao,
John A Flynn,
Lawrence Yao,
Michael M Ward

Ann Rheum Dis Published Online First: 23 January 2013 doi:10.1136/annrheumdis-2012-202661

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Clinical and epidemiological research: Extended report: Low-dose aspirin use and recurrent gout attacks

Yuqing Zhang,
Tuhina Neogi,
Clara Chen,
Christine Chaisson,
David J Hunter,
Hyon Choi

Ann Rheum Dis Published Online First: 23 January 2013 doi:10.1136/annrheumdis-2012-202589

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19 January 2013

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Clinical and epidemiological research: Extended report: Five-year outcomes of probable rheumatoid arthritis treated with methotrexate or placebo during the first year (the PROMPT study)

Jill van Aken,
Lotte Heimans,
Henrike Gillet-van Dongen,
Karen Visser,
H Karel Ronday,
Irene Speyer,
André J Peeters,
Tom W J Huizinga,
Cornelia F Allaart

Ann Rheum Dis Published Online First: 19 January 2013 doi:10.1136/annrheumdis-2012-202967

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Clinical and epidemiological research: Concise report: Tendon involvement in the feet of patients with gout: a dual-energy CT study

Nicola Dalbeth,
Ramanamma Kalluru,
Opetaia Aati,
Anne Horne,
Anthony J Doyle,
Fiona M McQueen

Ann Rheum Dis Published Online First: 19 January 2013 doi:10.1136/annrheumdis-2012-202786

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17 January 2013

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Basic and translational research: Extended report: IL-17/Th17 mediated synovial inflammation is IL-22 independent

Jan Piet van Hamburg,
Odilia B J Corneth,
Sandra M J Paulissen,
Nadine Davelaar,
Patrick S Asmawidjaja,
Adriana M C Mus,
Erik Lubberts

Ann Rheum Dis Published Online First: 17 January 2013 doi:10.1136/annrheumdis-2012-202373

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12 January 2013

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Clinical and epidemiological research: Extended report: Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study

Daniel J Wallace,
Kenneth Kalunian,
Michelle A Petri,
Vibeke Strand,
Frederic A Houssiau,
Marilyn Pike,
Brian Kilgallen,
Sabine Bongardt,
Anna Barry,
Lexy Kelley,
Caroline Gordon

Ann Rheum Dis Published Online First: 12 January 2013 doi:10.1136/annrheumdis-2012-202760

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Basic and translational research: Extended report: High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis

Anuradha Vivekanandan-Giri,
Jessica L Slocum,
Jaeman Byun,
Chongren Tang,
Robin L Sands,
Brenda W Gillespie,
Jay W Heinecke,
Rajiv Saran,
Mariana J Kaplan,
Subramaniam Pennathur

Ann Rheum Dis Published Online First: 12 January 2013 doi:10.1136/annrheumdis-2012-202033

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Basic and translational research: Extended report: Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis

Jessy Présumey,
Gabriel Courties,
Pascale Louis-Plence,
Virginie Escriou,
Daniel Scherman,
Yves-Marie Pers,
Hans Yssel,
Jérôme Pène,
Diego Kyburz,
Steffen Gay,
Christian Jorgensen,
Florence Apparailly

Ann Rheum Dis Published Online First: 12 January 2013 doi:10.1136/annrheumdis-2012-202403

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Clinical and epidemiological research: Extended report: Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout

Fernando Perez-Ruiz,
Lorea Martínez-Indart,
Loreto Carmona,
Ana Maria Herrero-Beites,
Jose Ignacio Pijoan,
Eswar Krishnan

Ann Rheum Dis Published Online First: 12 January 2013 doi:10.1136/annrheumdis-2012-202421

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11 January 2013

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Clinical and epidemiological research: Extended report: Adalimumab, a human anti-TNF monoclonal antibody, outcome study for the prevention of joint damage in Japanese patients with early rheumatoid arthritis: the HOPEFUL 1 study

Tsutomu Takeuchi,
Hisashi Yamanaka,
Naoki Ishiguro,
Nobuyuki Miyasaka,
Masaya Mukai,
Tsukasa Matsubara,
Shoji Uchida,
Hideto Akama,
Hartmut Kupper,
Vipin Arora,
Yoshiya Tanaka

Ann Rheum Dis Published Online First: 11 January 2013 doi:10.1136/annrheumdis-2012-202433

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8 January 2013

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Clinical and epidemiological research: Extended Report: Lymphoma risk in systemic lupus: effects of disease activity versus treatment

Sasha Bernatsky,
Rosalind Ramsey-Goldman,
Lawrence Joseph,
Jean-Francois Boivin,
Karen H Costenbader,
Murray B Urowitz,
Dafna D Gladman,
Paul R Fortin,
Ola Nived,
Michelle A Petri,
Soren Jacobsen,
Susan Manzi,
Ellen M Ginzler,
David Isenberg,
Anisur Rahman,
Caroline Gordon,
Guillermo Ruiz-Irastorza,
Edward Yelin,
Sang-Cheol Bae,
Daniel J Wallace,
Christine A Peschken,
Mary Anne Dooley,
Steven M Edworthy,
Cynthia Aranow,
Diane L Kamen,
Juanita Romero-Diaz,
Anca Askanase,
Torsten Witte,
Susan G Barr,
Lindsey A Criswell,
Gunnar K Sturfelt,
Irene Blanco,
Candace H Feldman,
Lene Dreyer,
Neha M Patel,
Yvan St Pierre,
Ann E Clarke

Ann Rheum Dis Published Online First: 8 January 2013 doi:10.1136/annrheumdis-2012-202099

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7 January 2013

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Clinical and epidemiological research: Extended report: Effects of golimumab, an anti-tumour necrosis factor-α human monoclonal antibody, on lipids and markers of inflammation

Bruce W Kirkham,
Mary Chester Wasko,
Elizabeth C Hsia,
Roy M Fleischmann,
Mark C Genovese,
Eric L Matteson,
Hongjuan Liu,
Mahboob U Rahman

Ann Rheum Dis Published Online First: 7 January 2013 doi:10.1136/annrheumdis-2012-202089

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Basic and translational research: Extended report: Long-term measurement of anti-adalimumab using pH-shift-anti-idiotype antigen binding test shows predictive value and transient antibody formation

Pauline A van Schouwenburg,
Charlotte L Krieckaert,
Theo Rispens,
Lucien Aarden,
Gerrit Jan Wolbink,
Diana Wouters

Ann Rheum Dis Published Online First: 7 January 2013 doi:10.1136/annrheumdis-2012-202407

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Clinical and epidemiological research: Extended report: Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study)

Nathalie Costedoat-Chalumeau,
Lionel Galicier,
Olivier Aumaître,
Camille Francès,
Véronique Le Guern,
Frédéric Lioté,
Amar Smail,
Nicolas Limal,
Laurent Perard,
Hélène Desmurs-Clavel,
Du Le Thi Huong Boutin,
Bouchra Asli,
Jean-Emmanuel Kahn,
Jacques Pourrat,
Laurent Sailler,
Félix Ackermann,
Thomas Papo,
Karim Sacré,
Olivier Fain,
Jerome Stirnemann,
Patrice Cacoub,
Moez Jallouli,
Gaelle Leroux,
Judith Cohen-Bittan,
Marie-Laure Tanguy,
Jean-Sébastien Hulot,
Philippe Lechat,
Lucile Musset,
Zahir Amoura,
Jean-Charles Piette

Ann Rheum Dis Published Online First: 10 November 2012 doi:10.1136/annrheumdis-2012-202322

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6 January 2013

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Basic and translational research: Extended report: The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium

Silke Frey,
Anja Derer,
Maria-Elena Messbacher,
Dominique L P Baeten,
Serena Bugatti,
Carlomaurizio Montecucco,
Georg Schett,
Axel J Hueber

Ann Rheum Dis Published Online First: 25 December 2012 doi:10.1136/annrheumdis-2012-202264

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3 January 2013

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Basic and translational research: Extended report: Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis

Ben T van den Brand,
Shahla Abdollahi-Roodsaz,
Miranda B Bennink,
Johan Bussink,
Onno J Arntz,
Wim B van den Berg,
Fons A J van de Loo

Ann Rheum Dis Published Online First: 3 January 2013 doi:10.1136/annrheumdis-2012-202467

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Clinical and epidemiological research: Extended report: The role of methotrexate co-medication in TNF-inhibitor treatment in patients with psoriatic arthritis: results from 440 patients included in the NOR-DMARD study

Karen Minde Fagerli,
Elisabeth Lie,
Désirée van der Heijde,
Marte Schrumpf Heiberg,
Åse Stavland Lexberg,
Eric Rødevand,
Synøve Kalstad,
Knut Mikkelsen,
Tore K Kvien

Ann Rheum Dis Published Online First: 3 January 2013 doi:10.1136/annrheumdis-2012-202347

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Clinical and epidemiological research: Concise report: Smoking and delay to diagnosis are associated with poorer functional outcome in psoriatic arthritis

William Tillett,
Deepak Jadon,
Gavin Shaddick,
Charlotte Cavill,
Eleanor Korendowych,
Corinne S de Vries,
Neil McHugh

Ann Rheum Dis Published Online First: 3 January 2013 doi:10.1136/annrheumdis-2012-202608

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25 December 2012

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Basic and translational research: Extended report: Epstein–Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis

Cristina Croia,
Barbara Serafini,
Michele Bombardieri,
Stephen Kelly,
Frances Humby,
Martina Severa,
Fabiana Rizzo,
Eliana Marina Coccia,
Paola Migliorini,
Francesca Aloisi,
Costantino Pitzalis

Ann Rheum Dis Published Online First: 25 December 2012 doi:10.1136/annrheumdis-2012-202352

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Clinical and epidemiological research: Extended report: Tabalumab, an anti-BAFF monoclonal antibody, in patients with active rheumatoid arthritis with an inadequate response to TNF inhibitors

Mark C Genovese,
Roy M Fleischmann,
Maria Greenwald,
Julie Satterwhite,
Melissa Veenhuizen,
Li Xie,
Pierre-Yves Berclaz,
Stephen Myers,
Olivier Benichou

Ann Rheum Dis Published Online First: 25 December 2012 doi:10.1136/annrheumdis-2012-202775

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Clinical and epidemiological research: Extended report: A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon

Laura K Hummers,
Carin E Dugowson,
Frederick J Dechow,
Robert A Wise,
Jeffrey Gregory,
Joel Michalek,
Gayane Yenokyan,
John McGready,
Fredrick M Wigley

Ann Rheum Dis Published Online First: 25 December 2012 doi:10.1136/annrheumdis-2012-201536

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Clinical and epidemiological research: Extended report: MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behçet's disease and Vogt–Koyanagi–Harada syndrome

Qingyun Zhou,
Shengping Hou,
Liang Liang,
Xinyu Li,
Xiaoyu Tan,
Lin Wei,
Bo Lei,
Aize Kijlstra,
Peizeng Yang

Ann Rheum Dis Published Online First: 25 December 2012 doi:10.1136/annrheumdis-2012-201627

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22 December 2012

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Clinical and epidemiological research: Extended report: Should I send my patient with previous giant cell arteritis for imaging of the thoracic aorta? A systematic literature review and meta-analysis

Sarah Louise Mackie,
Elizabeth M A Hensor,
Ann W Morgan,
Colin T Pease

Ann Rheum Dis Published Online First: 22 December 2012 doi:10.1136/annrheumdis-2012-202145

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Clinical and epidemiological research: Extended report: Treatment to lipid targets in patients with inflammatory joint diseases in a preventive cardio-rheuma clinic

Silvia Rollefstad,
Tore K Kvien,
Ingar Holme,
Anne S Eirheim,
Terje R Pedersen,
Anne Grete P Semb

Ann Rheum Dis Published Online First: 22 December 2012 doi:10.1136/annrheumdis-2012-202789

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21 December 2012

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Basic and translational research: Extended report: Foxp3⁺ Helios⁺ regulatory T cells are expanded in active systemic lupus erythematosus

Tobias Alexander,
Arne Sattler,
Lars Templin,
Siegfried Kohler,
Christian Groß,
Andreas Meisel,
Birgit Sawitzki,
Gerd-Rüdiger Burmester,
Renate Arnold,
Andreas Radbruch,
Andreas Thiel,
Falk Hiepe

Ann Rheum Dis Published Online First: 21 December 2012 doi:10.1136/annrheumdis-2012-202216

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Clinical and epidemiological research: Extended report: Risk of mortality in patients with psoriatic arthritis, rheumatoid arthritis and psoriasis: a longitudinal cohort study

Alexis Ogdie,
Kevin Haynes,
Andrea B Troxel,
Thorvardur Jon Love,
Sean Hennessy,
Hyon Choi,
Joel M Gelfand

Ann Rheum Dis Published Online First: 21 December 2012 doi:10.1136/annrheumdis-2012-202424

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Clinical and epidemiological research: Extended report: Annual direct medical cost of active systemic lupus erythematosus in five European countries

Andrea Doria,
Zahir Amoura,
Ricard Cervera,
Munther A Khamastha,
Matthias Schneider,
Jutta Richter,
Francis Guillemin,
Gisela Kobelt,
Frédérique Maurel,
Anna Garofano,
Alessandra Perna,
Miranda Murray,
Claude Schmitt,
Isabelle Boucot

Ann Rheum Dis Published Online First: 21 December 2012 doi:10.1136/annrheumdis-2012-202443

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Clinical and epidemiological research: Extended report: Circulating maternal cytokines influence fetal growth in pregnant women with rheumatoid arthritis

Florentien D O de Steenwinkel,
Anita C S Hokken-Koelega,
Yaël A de Man,
Y B de Rijke,
Maria A J de Ridder,
Johanna M W Hazes,
Radboud J E M Dolhain

Ann Rheum Dis Published Online First: 21 December 2012 doi:10.1136/annrheumdis-2012-202539

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20 December 2012

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Clinical and epidemiological research: Extended report: Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis

Flora Mcerlane,
Michael W Beresford,
Eileen M Baildam,
S E Alice Chieng,
Joyce E Davidson,
Helen E Foster,
Janet Gardner-Medwin,
Mark Lunt,
Lucy R Wedderburn,
Wendy Thomson,
Kimme L Hyrich

Ann Rheum Dis Published Online First: 20 December 2012 doi:10.1136/annrheumdis-2012-202031

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