Background Studies have shown moderate cognitive impairment in patients with Fibromyalgia syndrome (FMS). Mean platelet volume (MPV), a marker of platelet activation. Activated platelets may play role in neuroinflammation and cognitive dysfunction. In addition, recent clinical studies identified the relation between uric acid (UA) and cognitive impairment in neurological diseases.

Objectives Our aim was to compare the serum UA and MPV levels between FMS patients and control subjects and to investigate the relationship between UA, MPV and cognitive impairment in patients with FMS.

Methods A total of 54 premenopausal female patients with FMS diagnosed according to 1990, 2010 and 2013 ACR criteria referring to Physical Medicine and Rehabilitation outpatient clinic and 33 volunteer healthy control matched according to their ages and genders were enrolled. Visual Analog Scale (VAS), to assess pain and sleep quality, and Fibromyalgia Impact Questionnaire (FIQ), to evaluate the functional status, were used in both groups. We assessed the psychological status with Beck Depression Inventory (BDI) and the frequency of cognitive impairment was evaluated with Mini Mental State Examination (MMSE). Serum MPV, platelet and UA levels were measured. Results were evaluated considering the significance level p<0.05.

Results No statistically significant difference was observed demographic characteristics between FMS and control groups (p>0.05). Mean VAS pain and sleep quality of FMS group were determined significantly higher than control group (p<0.05). Significant differences were found in FIQ and BDI scores of FMS patients compared to controls (p<0.05). The mean of MMSE score was statistically significantly lower than control group (p<0.05). No statistically significant difference was observed in MPV, platelet and UA between FMS and control groups (p>0.05). No significant correlation was determined between serum UA levels and VAS pain/sleep quality, FIQ, BDI and MMSE scores (p>0.05). Similarly, no significant correlation was found between serum MPV levels and VAS pain/sleep quality, FIQ, BDI and MMSE scores (p>0.05).

Conclusions Our results suggest that there were no association between serum UA, MPV and cognitive impairment levels in FMS patients in comparison to control subjects. Many variables, such as age, pain, depression and poor functional status, likely contribute to the cognitive impairment in FMS.

References

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Disclosure of Interest None declared