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Absence of anti-cyclic citrullinated peptide antibodies in erosive osteoarthritis: further serological evidence of the disease as a subset of osteoarthritis
  1. G Morozzi,
  2. F Bellisai,
  3. A Fioravanti,
  4. M Galeazzi
  1. Dipartimento di Medicina Clinica e Scienze Immunologiche, Sezione di Reumatologia, Università di Siena, Italia
  1. Correspondence to:
    Dr G Morozzi
    Dipartimento di Medicina Clinica e Scienze Immunologiche, Sezione di Reumatologia, Università di Siena, Policlinico Le Scotte, 53100 Siena, Italia; morozziunisi.it

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Erosive osteoarthritis (EOA) is considered to be a rare subset of osteoarthritis (OA) characterised by destructive changes involving the proximal interphalangeal and distal interphalangeal joints.1–3 Laboratory findings are usually negative even though a slight increase of erythrocyte sedimentation rate may occur.2,3 Radiologically, central erosions and the “gull wing” deformity characterise the disorder.4 Synovial pathology shows changes consistent with both rheumatoid arthritis (RA) and OA.1,2 Histological examination of synovium from patients with EOA joints shows lining cell hyperplasia, lymphocytic infiltration, and pannus formation, features indistinguishable from those of RA.1

The relationship between EOA and classical OA is controversial, as some authors consider it to be a separate disease entity, some regard it as one end of the …

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