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Apoptosis and the subsequent generation of autoantigens as initial triggers in the pathogenesis of experimental autoimmune arthritis
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  1. S Herman,
  2. M Hoffmann,
  3. A Kny,
  4. J Smolen,
  5. G Steiner
  1. Internal Medicine III, Department of Rheumatology, Medical University of Vienna, Austria

https://doi.org/10.1136/ard.2010.129650b

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    Background

    Rheumatoid arthritis (RA) has a definite autoimmune pathogenesis. Rising evidence suggests that deregulated and/or deficient clearance of apoptotic materials may lead to the release of potential autoantigens provoking a break in the self-tolerance mechanism. Major autoantigens in RA include immunoglobulin G, the target of rheumatoid factor (RF), citrullinated proteins and the heterogeneous nuclear ribonucleoprotein (hnRNP) A2. To gain more insight into the role of apoptotic processes in lymphoid tissues in the generation of arthritogenic autoantigens, we studied the …

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