Open access

Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study

Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yong-Fei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Yu Lung Lau, Ken Yamaji, Zhengwei Zhu, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Kazuhiko Yamamoto, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae

10.1136/annrheumdis-2022-222345

May 24, 2022

Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching

Xiaoyang Yue, Junping Yin, Xiaoqing Wang, Harald Heidecke, Alexander Maximilian Hackel, Xiaoru Dong, Brigitte Kasper, Lifang Wen, Liang Zhang, Kai Schulze-Forster, Juliane Junker, Hanna Grasshoff, Antje Müller, Gerd Wallukat, Ingolf Schimke, Julian Zeiner, Lisa Marie Deckstein, Nicole Mertens, Anja Kerstein-Staehle, Jennifer Elisabeth Hundt, Evi Kostenis, Xinhua Yu, Gabriela Riemekasten, Frank Petersen

10.1136/annrheumdis-2021-222088

May 20, 2022

Biological impact of iberdomide in patients with active systemic lupus erythematosus

Peter E Lipsky, Ronald van Vollenhoven, Thomas Dörner, Victoria P Werth, Joan T Merrill, Richard Furie, Milan Petronijevic, Benito Velasco Zamora, Maria Majdan, Fedra Irazoque-Palazuelos, Robert Terbrueggen, Nikolay Delev, Michael Weiswasser, Shimon Korish, Mark Stern, Sarah Hersey, Ying Ye, Allison Gaudy, Zhaohui Liu, Robert Gagnon, Shaojun Tang, Peter H Schafer

10.1136/annrheumdis-2022-222212

April 27, 2022

Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function

Sabrina Meisgen, Malin Hedlund, Aurelie Ambrosi, Lasse Folkersen, Vijole Ottosson, David Forsberg, Gudny Ella Thorlacius, Luca Biavati, Linn Strandberg, Johannes Mofors, Daniel Ramskold, Sabrina Ruhrmann, Lauro Meneghel, William Nyberg, Alexander Espinosa, Robert Murray Hamilton, Anders Franco-Cereceda, Anders Hamsten, Tomas Olsson, Lois Greene, Per Eriksson, Kristina Gemzell-Danielsson, Stina Salomonsson, Vijay K Kuchroo, Eric Herlenius, Ingrid Kockum, Sven-Erik Sonesson, Marie Wahren-Herlenius

10.1136/annrheumdis-2021-221714

April 25, 2022

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saedis Saevarsdottir, Lilja Stefansdottir, Patrick Sulem, Gudmar Thorleifsson, Egil Ferkingstad, Gudrun Rutsdottir, Bente Glintborg, Helga Westerlind, Gerdur Grondal, Isabella C Loft, Signe Bek Sorensen, Benedicte A Lie, Mikael Brink, Lisbeth Ärlestig, Asgeir Orn Arnthorsson, Eva Baecklund, Karina Banasik, Steffen Bank, Lena I Bjorkman, Torkell Ellingsen, Christian Erikstrup, Oleksandr Frei, Inger Gjertsson, Daniel F Gudbjartsson, Sigurjon A Gudjonsson, Gisli H Halldorsson, Oliver Hendricks, Jan Hillert, Estrid Hogdall, Søren Jacobsen, Dorte Vendelbo Jensen, Helgi Jonsson, Alf Kastbom, Ingrid Kockum, Salome Kristensen, Helga Kristjansdottir, Margit H Larsen, Asta Linauskas, Ellen-Margrethe Hauge, Anne G Loft, Bjorn R Ludviksson, Sigrun H Lund, Thorsteinn Markusson, Gisli Masson, Pall Melsted, Kristjan H S Moore, Heidi Munk, Kaspar R Nielsen, Gudmundur L Norddahl, Asmundur Oddsson, Thorunn A Olafsdottir, Pall I Olason, Tomas Olsson, Sisse Rye Ostrowski, Kim Hørslev-Petersen, Solvi Rognvaldsson, Helga Sanner, Gilad N Silberberg, Hreinn Stefansson, Erik Sørensen, Inge J Sørensen, Carl Turesson, Thomas Bergman, Lars Alfredsson, Tore K Kvien, Søren Brunak, Kristján Steinsson, Vibeke Andersen, Ole A Andreassen, Solbritt Rantapää-Dahlqvist, Merete Lund Hetland, Lars Klareskog, Johan Askling, Leonid Padyukov, Ole BV Pedersen, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson, Members of the DBDS Genomic Consortium, The Danish RA Genetics Working Group, Members of the DBDS Genomic Consortium, Steffen Andersen, Karina Banasik, Søren Brunak, Kristoffer Burgdorf, Christian Erikstrup, Thomas Folkmann Hansen, Henrik Hjalgrim, Gregor Jemec, Poul Jennum, Pär Ingemar Johansson, Kasper Rene Nielsen, Mette Nyegaard, Mie Topholm Brun, Ole Birger Pedersen, Susan Mikkelsen, Khoa Manh Dinh, Erik Sørensen, Henrik Ullum, Sisse Rye Ostrowski, Thomas Werge, Daniel Gudbjartsson, Kari Stefansson, Hreinn Stefánsson, Unnur Þorsteinsdóttir, Margit Anita Hørup Larsen, Maria Didriksen, Susanne Sækmose, The Danish RA Genetics Working Group, Paal Skytt Andersen, Ram Benny Dessau, Malene Rohr Andersen, Hans Jürgen Hoffmann, Claus Lohman Brasen, The Swedish Rheumatology Quality Register Biobank Study Group (SRQb), Johan Askling, Eva Baecklund, Lena Bjorkman, Alf Kastbom, Solbritt Rantapaa-Dahlqvist, Carl Turesson

10.1136/annrheumdis-2021-221754

April 25, 2022

Development and preliminary validation of the Sjögren’s Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren’s syndrome

Raphaele Seror, Gabriel Baron, Marine Camus, Divi Cornec, Elodie Perrodeau, Simon J Bowman, Michele Bombardieri, Hendrika Bootsma, Jacques-Eric Gottenberg, Benjamin Fisher, Wolfgang Hueber, Joel A van Roon, Valérie Devauchelle-Pensec, Peter Gergely, Xavier Mariette, Raphael Porcher, on behalf of the NECESSITY WP5- STAR development working group, Suzanne Arends, Francesca Barone, Albin Björk, Coralie Bouillot, Guillermo Carvajal Alegria, Wen-Hung Chen, Kenneth Clark, Konstantina Delli, Liseth de Wolff, Jennifer Evans, Stéphanie Galtier, Saviana Gandolfo, Mickael Guedj, Dewi Guellec, Safae Hamkour, Dominik Hartl, Malin V Jonsson, Roland Jonsson, Frans G M Kroese, Aike Albert Kruize, Laurence Laigle, Véronique Le Guern, Wen-Lin Luo, Esther Mossel, Wan-Fai Ng, Gaëtane Nocturne, Marleen Nys, Roald Omdal, Jacques-Olivier Pers, Maggy Pincemin, Manel Ramos-Casals, Philippe Ravaud, Neelanjana Ray, Alain Saraux, Athanasios Tzioufas, Gwenny Verstappen, Arjan Vissink, Marie Wahren-Herlenius

10.1136/annrheumdis-2021-222054

April 7, 2022