Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease
10.1136/annrheumdis-2018-214865
August 12, 2019
Systemic sclerosis
Myeloablation followed by autologous stem cell transplantation normalises systemic sclerosis molecular signatures
Shervin Assassi, Xuan Wang, Guocai Chen, Ellen Goldmuntz, Lynette Keyes-Elstein, Jun Ying, Paul K Wallace, Jacob Turner, W Jim Zheng, Virginia Pascual, John Varga, Monique E Hinchcliff, Chiara Bellocchi, Peter McSweeney, Daniel E Furst, Richard A Nash, Leslie J Crofford, Beverly Welch, Ashley Pinckney, Maureen D Mayes, Keith M Sullivan
10.1136/annrheumdis-2019-215770
August 7, 2019
Vasodilators and low-dose acetylsalicylic acid are associated with a lower incidence of distinct primary myocardial disease manifestations in systemic sclerosis: results of the DeSScipher inception cohort study
Gabriele Valentini, Dörte Huscher, Antonella Riccardi, Serena Fasano, Rosaria Irace, Valentina Messiniti, Marco Matucci-Cerinic, Serena Guiducci, Oliver Distler, Britta Maurer, Jérôme Avouac, Ingo H Tarner, Marc Frerix, Gabriela Riemekasten, Elise Siegert, László Czirják, Veronika Lóránd, Christopher P Denton, Svetlana Nihtyanova, Ulrich A Walker, Veronika K Jaeger, Francesco Del Galdo, Giuseppina Abignano, Lidia P Ananieva, Ana Maria Gherghe, Carina Mihai, Joerg Christoph Henes, Tim Schmeiser, Alessandra Vacca, Sergey Moiseev, Ivan Foeldvari, Armando Gabrielli, Brigitte Krummel-Lorenz, Simona Rednic, Yannick Allanore, Ulf Müeller-Ladner
10.1136/annrheumdis-2019-215486
August 7, 2019
Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a European Scleroderma Trials and Research (EUSTAR) analysis
Mike Becker, Nicole Graf, Rafael Sauter, Yannick Allanore, John Curram, Christopher P Denton, Dinesh Khanna, Marco Matucci-Cerinic, Janethe de Oliveira Pena, Janet E Pope, Oliver Distler, EUSTAR Collaborators (numerical order of centres), Marco Matucci-Cerinic, Serena Guiducci, Veronika Jaeger, Bettina Bannert, Giovanni Lapadula, Radim Becvarare, Gabriele Valentini, Elise Siegert, Simona Rednic, Yannick Allanore, Patricia E Carreira, Srdan Novak, László Czirják, Cecilia Varju, Daniela Allai, Franco Cozzi, Blaz Rozman, Armando Gabrielli, Dominique Farge Bancel, Paolo Airò, Alexandra Balbir-Gurman, Raffaele Pellerito, Paola Caramaschi, Nemanja Damjanov, Jörg Henes, Vera Ortiz Santamaria, Stefan Heitmann, Matthias Seidel, Serena Guiducci, Ulrich Walker, Veronika Jaeger, Serena Guiducci, Veronika Jaeger, Bettina Bannert, Giovanni Lapadula, Radim Becvarare, Maurizio Cutolo, Elise Siegert, Simona Rednic, Yannick Allanore, Patricia E. Carreira, Srdan Novak, László Czirják, Cecilia Varju, Daniela Allai, Eugene J. Kucharz, Franco Cozzi, Blaz Rozman, Armando Gabrielli, Dominique Farge Bancel, Paolo Airò, Duska Martinovic, Alexandra Balbir-Gurman, Nicolas Hunzelmann, Raffaele Pellerito, Paola Caramaschi, Nemanja Damjanov, Jörg Henes, Vera Ortiz Santamaria, Stefan Heitmann, Matthias Seidel, José Antonio Pereira Da Silva, Bojana Stamenkovic, Carlo Francesco Selmi, Lev N Denisov, Ulf Müller-Ladner, Merete Engelhart, Eric Hachulla, Valeria Riccieri, Ruxandra Maria Ionescu, Carina Mihai, Cord Sunderkötter, Annegret Kuhn, Georg Schett, Jörg Distler, Pierluigi Meroni, Luc Mouthon, Filip De Keyser, Vanessa Smith, Francesco Paolo Cantatore, Ada Corrado, Susanne Ullman, Line Iversen, Maria Rosa Pozzi, Kilian Eyerich, Rüdiger Hein, Piotr Wiland, Magdalena Szmyrka-Kaczmarek, Renata Sokolik, Ewa Morgiel, Marta Madej, Juan Jose Alegre-Sancho, Brigitte Krummel-Lorenz, Petra Saar, Martin Aringer, Claudia Günther, Erler Anne, Rene Westhovens, Ellen De Langhe, Jan Lenaerts, Branimir Anic, Marko Baresic, Miroslav Mayer, Maria Ãœprus, Kati Otsa, Sule Yavuz, Sebastião Cezar Radominski, Sergei Popa, Thierry Zenone, Simon Stebbings, John Highton, Alessandro Mathieu, Alessandra Vacca, Lisa Stamp, Peter Chapman, John O'Donnell, Kamal Solanki, Alan Doube, Douglas Veale, Marie O'Rourke, Esthela Loyo, Mengtao Li, Edoardo Rosato, Antonio Amoroso, Antonietta Gigante, Fahrettin Oksel, Figen Yargucu, Cristina-Mihaela Tanaseanu, Monica Popescu, Alina Dumitrascu, Isabela Tiglea, Rosario Foti, Elisa Visalli, Alessia Benenati, Giorgio Amato, Codrina Ancuta, Rodica Chirieac, Peter Villiger, Sabine Adler, Paloma GarcÃa de la Peña Lefebvre, Silvia Rodriguez Rubio, Jean Sibilia, Emmanuel Chatelus, Jacques Eric Gottenberg, Hélène Chifflot, Ira Litinsky, Francesco Del Galdo, Algirdas Venalis, Lesley Ann Saketkoo, Eduardo Kerzberg, Fabiana Montoya, Vanesa Cosentino, Massimiliano Limonta, Antonio Luca Brucato, Elide Lupi, François Spertini, Camillo Ribi, Guillaume Buss, Thierry Martin, Aurélien Guffroy, Vincent Poindron, Lori Chung, Tim Schmeiser, Pawel Zebryk, Nuno Riso, Gabriela Riemekasten, Elena Rezus, Piercarlo Sarzi Puttini, Carlo Chizzolini
10.1136/annrheumdis-2019-215145
June 21, 2019
Acyltransferase skinny hedgehog regulates TGFβ-dependent fibroblast activation in SSc
Ruifang Liang, Rosebeth Kagwiria, Ariella Zehender, Clara Dees, Christina Bergmann, Andreas Ramming, Dorota Krasowska, Małgorzata Michalska-Jakubus, Alexander Kreuter, Max E Kraner, Georg Schett, Jörg H W Distler
10.1136/annrheumdis-2019-215066
June 8, 2019
Blockade of CCL24 with a monoclonal antibody ameliorates experimental dermal and pulmonary fibrosis
Adi Mor, Michal Segal Salto, Avi Katav, Neta Barashi, Victoria Edelshtein, Mirko Manetti, Yair Levi, Jacob George, Marco Matucci-Cerinic
10.1136/annrheumdis-2019-215119
May 25, 2019
Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis
Alsya J Affandi, Tiago Carvalheiro, Andrea Ottria, Jasper CA Broen, Lara Bossini-Castillo, Ralph G Tieland, Lenny van Bon, Eleni Chouri, Marzia Rossato, Jorre S Mertens, Samuel Garcia, Aridaman Pandit, Laurie MG de Kroon, Romy B Christmann, Javier Martin, Joel AG van Roon, Timothy RDJ Radstake, Wioleta Marut
10.1136/annrheumdis-2018-214991
May 24, 2019
Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
Muriel Elhai, Marouane Boubaya, Oliver Distler, Vanessa Smith, Marco Matucci-Cerinic, Juan José Alegre Sancho, Marie-Elise Truchetet, Yolanda Braun-Moscovici, Florenzo Iannone, Pavel I Novikov, Alain Lescoat, Elise Siegert, Ivan CastellvÃ, Paolo Airó, Serena Vettori, Ellen De Langhe, Eric Hachulla, Anne Erler, Lidia Ananieva, Martin Krusche, F J López-Longo, Jörg H W Distler, Nicolas Hunzelmann, Anna-Maria Hoffmann-Vold, Valeria Riccieri, Vivien M Hsu, Maria R Pozzi, Codrina Ancuta, Edoardo Rosato, Carina Mihai, Masataka Kuwana, Lesley Ann Saketkoo, Carlo Chizzolini, Roger Hesselstrand, Susanne Ullman, Sule Yavuz, Simona Rednic, Cristian Caimmi, Coralie Bloch-Queyrat, Yannick Allanore, for EUSTAR network, Serena Guiducci, Ulrich A Walker, Diego Kyburz, Giovanni Lapadula, Britta Maurer, Suzana Jordan, Rucsandra Dobrota, Radim Becvar, Stanislaw Sierakowsky, Otylia Kowal Bielecka, Alberto Sulli, Maurizio Cutolo, Giovanna Cuomo, Ileana Nicoara, André Kahan, Panayiotis G Vlachoyiannopoulos, Carlo Maurizio Montecucco, Roberto Caporali, Jiri Stork, Murat Inanc, Patricia E Carreira, Srdan Novak, László Czirják, Cecilia Varju, Eugene J Kucharz, Anna Kotulska, Magdalena Kopec-Medrek, Malgorzata Widuchowska, Franco Cozzi, Blaz Rozman, Carmel Mallia, Bernard Coleiro, Armando Gabrielli, Dominique Farge, Chen Wu, Zora Marjanovic, Helene Faivre, Darin Hij, Roza Dhamadi, Frank Wollheim, Agneta Scheja, Dirk M Wuttge, Kristofer Andréasson, Duska Martinovic, Alexandra Balbir-Gurman, F Trotta, Andrea Lo Monaco, Raffaele Pellerito, Ospedale Mauriziano, Paola Caramaschi, Jadranka Morovic-Vergles, Carol Black, Christopher Denton, Nemanja Damjanov, Jörg Henes, Vera Ortiz Santamaria, Stefan Heitmann, Dorota Krasowska Matthias, Paul Hasler, Harald Burkhardt, Andrea Himsel, Gianluigi Bajocchi, José Antonio Pereira Da Silva, Maria João Salvador, Bojana Stamenkovic, Aleksandra Stankovic, Carlo Francesco Selmi, Maria De Santis, Mohammed Tikly, Lev N Denisov, Ulf Müller-Ladner, Marc Frerix, Ingo Tarner, Raffaella Scorza, Francesco Puppo, Merete Engelhart, Gitte Strauss, Henrik Nielsen, Kirsten Damgaard, Gabriela Szücs, Antonio Zea Mendoza, Carlos de la Puente, WA Sifuentes Giraldo, Øyvind Midtvedt, Silje Reiseter, Torhild Garen, David Launay, Guido Valesini, Ruxandra Maria Ionescu, Laura Groseanu, Daniela Opris, Roxana Sfrent Cornateanu, Razvan Ionitescu, Ana Maria Gherghe, Alina Soare, Marilena Gorga, Mihai Bojinca, Mihaela Milicescu, Cord Sunderkötter, Annegret Kuhn, Nora Sandorfi, Georg Schett, Christian Beyer, Pierluigi Meroni, Francesca Ingegnoli, Luc Mouthon, Filip De Keyser, Karin Melsens, Francesco P Cantatore, Ada Corrado, Line Iversen, Carlos Alberto von Mühlen, Jussara Marilu Bohn, Lilian Scussel Lonzetti, Kilian Eyerich, Rüdiger Hein, Elisabeth Knott, Piotr Wiland, Magdalena Szmyrka-Kaczmarek, Renata Sokolik, Ewa Morgiel, Marta Madej, Frédéric A Houssiau, Brigitte Krummel-Lorenz, Petra Saar, Martin Aringer, Claudia Günther, Rene Westhovens, Jan Lenaerts, Branimir Anic, Marko Baresic, Miroslav Mayer, Maria Ãœprus, Kati Otsa, Brigitte Granel, Carolina de Souza Müller, Sebastião C Radominski, ValderÃlio F Azevedo, Sergio Jimenez, Joanna Busquets, Svetlana Agachi, Liliana Groppa, Lealea Chiaburu, Eugen Russu, Sergei Popa, Thierry Zenone, Margarita Pileckyte, Alessandro Mathieu, Alessandra Vacca, Percival D Sampaio-Barros, Natalino H Yoshinari, Roberta G Marangoni, PatrÃcia Martin, Luiza Fuocco, Simon Stebbings, John Highton, Peter Chapman, John O’Donnell, Lisa Stamp, Alan Doube, Kamal Solanki, Douglas Veale, Marie O’Rourke, Esthela Loyo, Mengtao Li, Walid Ahmed Abdel Atty Mohamed, Antonio Amoroso, Antonietta Gigante, Fahrettin Oksel, Figen Yargucu, Cristina-Mihaela Tanaseanu, Monica Popescu, Alina Dumitrascu, Isabela Tiglea, Rosario Foti, Rodica Chirieac, Daniel Furst, Peter Villiger, Sabine Adler, Jacob van Laar, Cristiane Kayser, Nihal Fathi, Manal Hassanien, Paloma GarcÃa de la Peña Lefebvre, Silvia Rodriguez Rubio, Marta Valero Exposito, Emmanuel Chatelus, Jean Sibilia, Jacques Eric Gottenberg, Hélène Chifflot, Ira Litinsky, Paul Emery, Maya Buch, Francesco Del Galdo, Algirdas Venalis, Irena Butrimiene, Paulius Venalis, Rita Rugiene, Diana Karpec, Joseph A Lasky, Vanesa Cosentino, Eduardo Kerzberg, Fabiana Montoya, Washington Bianchi, Sueli Carneiro, Giselle Baptista Maretti, Dante Valdetaro Bianchi, Massimiliano Limonta, Antonio Luca Brucato, Elide Lupi, Itzhak Rosner, Michael Rozenbaum, Gleb Slobodin, Nina Boulman, Doron Rimar, Maura Couto, Sarah Kahl, Fei Chen, Deborah McCloskey, Halina Malveaux, François Spertini, Camillo Ribi, Guillaume Buss, Thierry Martin, Aurélien Guffroy, Vincent Poindron, Fatima Chotchaeva, Nikolay A Mukhin, Sergey Moiseev, Ariane Herrick
10.1136/annrheumdis-2018-214816
April 9, 2019
Compendium of skin molecular signatures identifies key pathological features associated with fibrosis in systemic sclerosis
Su-Jin Moon, Jung Min Bae, Kyung-Su Park, Ilias Tagkopoulos, Ki-Jo Kim
10.1136/annrheumdis-2018-214778
April 5, 2019
Development and validation of the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis
Nava Ferdowsi, Molla Huq, Wendy Stevens, Marie Hudson, Mianbo Wang, Tien Tay, Jodie L Burchell, Sam Mancuso, Candice Rabusa, Vijaya Sundararajan, David Prior, Susanna M Proudman, Murray Baron, Mandana Nikpour, The Scleroderma Clinical Trials Consortium Damage Index Working Group, TheAustralian Scleroderma Interest Group, Canadian Scleroderma Research Group, Mandana Nikpour, Nava Ferdowsi MurrayBaron, Tracy Frech, Marie Hudson, Susanna Proudman, Tien Tay WendyStevens, Lorinda Chung, Jessica K Gordon, Anna Haemel, Sindhu RJohnson, Dinesh Khanna, Thomas A Medsger, John Pauling, Janet E Pope, Lesley Saketkoo TatianaRodriguez-Reyna, James R Seibold, Ankoor Shah, Virginia Steen, Gemma Strickland, Catherine Hill, Mandana Nikpour Gene-SiewNgian, Susanna Proudman, Maureen Rischmueller, Janet Roddy, Wendy Stevens JoanneSahhar, Gemma Strickland, Jenny Walker, Peter Youssef, J. Pope, M. Baron, D. Robinson, N. Jones, N. Khalidi, P. Docherty, E. Kaminska, E. Sutton, J-P. Mathieu, M. Hudson, S. Ligier, T. Grodzicky, C. Thorne, G. Gyger, D. Smith, P.R. Fortin, M. Larché, M. Abu-Hakima, TS Rodriguez-Reyna, AR Cabral, M. Fritzler, Peter Merkel
10.1136/annrheumdis-2018-214764
March 30, 2019