Systemic sclerosis

Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma

Rebecca L Ross, Clarissa Corinaldesi, Gemma Migneco, Ian M Carr, Agne Antanaviciute, Christopher W Wasson, Antonio Carriero, Jörg H W Distler, Steve Holmes, Yasser M El-Sherbiny, Clive S McKimmie, Francesco Del Galdo

10.1136/annrheumdis-2020-218439

February 4, 2021

Autoantibodies targeting telomere-associated proteins in systemic sclerosis

Brittany L Adler, Francesco Boin, Paul J Wolters, Clifton O Bingham, Ami A Shah, Carol Greider, Livia Casciola-Rosen, Antony Rosen

10.1136/annrheumdis-2020-218918

January 25, 2021

New composite endpoint in early diffuse cutaneous systemic sclerosis: revisiting the provisional American College of Rheumatology Composite Response Index in Systemic Sclerosis

Dinesh Khanna, Suiyuan Huang, Celia J F Lin, Cathie Spino

10.1136/annrheumdis-2020-219100

November 30, 2020

Anti-centromere antibodies target centromere–kinetochore macrocomplex: a comprehensive autoantigen profiling

Nobuhiko Kajio, Masaru Takeshita, Katsuya Suzuki, Yukari Kaneda, Humitsugu Yamane, Kazuhiro Ikeura, Hidekazu Sato, Shin Kato, Hiroyuki Shimizu, Kazuyuki Tsunoda, Tsutomu Takeuchi

10.1136/annrheumdis-2020-218881

November 18, 2020

Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement

Kimberly Showalter, Robert Spiera, Cynthia Magro, Phaedra Agius, Viktor Martyanov, Jennifer M Franks, Roshan Sharma, Heather Geiger, Tammara A Wood, Yaxia Zhang, Caryn R Hale, Jackie Finik, Michael L Whitfield, Dana E Orange, Jessica K Gordon

10.1136/annrheumdis-2020-217840

October 7, 2020

Genomic Risk Score impact on susceptibility to systemic sclerosis

Lara Bossini-Castillo, Gonzalo Villanueva-Martin, Martin Kerick, Marialbert Acosta-Herrera, Elena López-Isac, Carmen P Simeón, Norberto Ortego-Centeno, Shervin Assassi, International SSc Group, Australian Scleroderma Interest Group (ASIG), PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry study group, Nicolas Hunzelmann, Armando Gabrielli, J K de Vries-Bouwstra, Yannick Allanore, Carmen Fonseca, Christopher P Denton, Timothy RDJ Radstake, Marta Eugenia Alarcón-Riquelme, Lorenzo Beretta, Maureen D Mayes, Javier Martin, Australian Scleroderma Interest Group (ASIG), J. Zochling, J. Sahhar, J. Roddy, P. Nash, K. Tymms, M. Rischmueller, S. Lester, PRECISESADS collaborator group, Doreen Belz, Francesca Ingegnoli, Yolanda Jimenez Gómez, Chary Lopez Pedrera, Rik Lories, Eduardo Collantes-Estevez, Gaia Montanelli, Silvia Piantoni, Ignasi Rodriguez Pinto, Carlos Vasconcelos, PRECISESADS Flow Cytometry study group, Christophe Jamin, Concepción Marañón, Lucas Le Lann, Quentin Simon, Bénédicte Rouvière, Nieves Varela, Brian Muchmore, Aleksandra Dufour, Montserrat Alvarez, Jonathan Cremer, Nuria Barbarroja, Velia Gerl, Laleh Khodadadi, Qingyu Cheng, Anne Buttgereit, Aurélie De Groof, Julie Ducreux, Elena Trombetta, Tianlu Li, Damiana Alvarez-Errico, Torsten Witte, Katja Kniesch, Nancy Azevedo, Esmeralda Neves, Nancy Azevedo, Esmeralda Neves, Sambasiva Rao, Pierre-Emmanuel Jouve

10.1136/annrheumdis-2020-218558

October 1, 2020

Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database

Anna-Maria Hoffmann-Vold, Yannick Allanore, Margarida Alves, Cathrine Brunborg, Paolo Airó, Lidia P Ananieva, László Czirják, Serena Guiducci, Eric Hachulla, Mengtao Li, Carina Mihai, Gabriela Riemekasten, Petros P Sfikakis, Otylia Kowal-Bielecka, Antonella Riccardi, Oliver Distler, on behalf of EUSTAR collaborators, Marco Matucci Cerinic, Ulrich Walker, Florenzo Iannone, Radim Becvar, Gabriele Valentini, Elise Siegert, C. Montecucco, Patricia E. Carreira, Carlo Chizzolini, Eugene J. Kucharz, Andrea Doria, Pr Dominique Farge Bancel, Roger Hesselstrand, Alexandra Balbir-Gurman, Raffaele Pellerito, Cristian Caimmi, Christopher Denton, Nemanja Damjanov, Jörg Henes, Vera Ortiz-Santamaria; Stefan Heitmann, Maria João Salvador, Bojana Stamenkovic, Carlo Francesco Selmi, Ariane Herrick, Ulf Müller-Ladner, Merete Engelhart, Valeria Riccieri, Ruxandra Maria Ionescu, Ana Maria Gheorghiu, Cord Sunderkötter, Jörg Distler, Francesca Ingegnoli, Luc Mouthon, Vanessa Smith, Francesco Paolo Cantatore, Susanne Ullman, Maria Rosa Pozzi, Piotr Wiland, Marie Vanthuyne, Brigitte Krummel-Lorenz, Petra Saar, Kristine Herrmann, Ellen De Langhe, Branimir Anic, Marko Baresic, Miroslav Mayer, Sule Yavuz, Carolina de Souza Müller, Thierry Zenone, Alessandro Mathieu, Alessandra Vacca, Kamal Solanki, Edoardo Rosato, Fahrettin Oksel, Figen Yargucu, Cristina-Mihaela Tanaseanu, Rosario Foti, Daniel E. Furst, Peter Villiger, Sabine Adler, Paloma García de la Peña Lefebvre, Jorge Juan González Martín, Ira Litinsky, Francesco Del Galdo, Goda Seskute, Lesley Ann Saketkoo, Eduardo Kerzberg, Ivan Castellví, François Spertini, Vivien M. Hsu, Thierry Martin, Tim Schmeiser, Dominik Majewski; Vera Bernardino, Piercarlo Sarzi Puttini

10.1136/annrheumdis-2020-217455

September 28, 2020

A randomised, double-blind, placebo-controlled, 24-week, phase II, proof-of-concept study of romilkimab (SAR156597) in early diffuse cutaneous systemic sclerosis

Yannick Allanore, Peter Wung, Christina Soubrane, Corinne Esperet, Frederic Marrache, Raphael Bejuit, Amel Lahmar, Dinesh Khanna, Christopher P Denton

10.1136/annrheumdis-2020-218447

September 22, 2020

Machine learning predicts stem cell transplant response in severe scleroderma

Jennifer M Franks, Viktor Martyanov, Yue Wang, Tammara A Wood, Ashley Pinckney, Leslie J Crofford, Lynette Keyes-Elstein, Daniel E Furst, Ellen Goldmuntz, Maureen D Mayes, Peter McSweeney, Richard A Nash, Keith M Sullivan, Michael L Whitfield

10.1136/annrheumdis-2020-217033

September 15, 2020

Safety and tolerability of nintedanib in patients with systemic sclerosis-associated interstitial lung disease: data from the SENSCIS trial

James R Seibold, Toby M Maher, Kristin B Highland, Shervin Assassi, Arata Azuma, Laura Kathleen Hummers, Ulrich Costabel, Ute von Wangenheim, Veronika Kohlbrenner, Martina Gahlemann, Margarida Alves, Oliver Distler

10.1136/annrheumdis-2020-217331

August 5, 2020