Systemic sclerosis

Safety and tolerability of nintedanib in patients with systemic sclerosis-associated interstitial lung disease: data from the SENSCIS trial

James R Seibold, Toby M Maher, Kristin B Highland, Shervin Assassi, Arata Azuma, Laura Kathleen Hummers, Ulrich Costabel, Ute von Wangenheim, Veronika Kohlbrenner, Martina Gahlemann, Margarida Alves, Oliver Distler

10.1136/annrheumdis-2020-217331

August 5, 2020

Quantitative analysis of pulmonary vasculature in systemic sclerosis at spirometry-gated chest CT

Mariaelena Occhipinti, Cosimo Bruni, Gianna Camiciottoli, Maurizio Bartolucci, Silvia Bellando-Randone, Anna Bassetto, Giovanna Cuomo, Dilia Giuggioli, Giulia Ciardi, Alessio Fabbrizzi, Sara Tomassetti, Federico Lavorini, Massimo Pistolesi, Stefano Colagrande, Marco Matucci-Cerinic

10.1136/annrheumdis-2020-217359

June 30, 2020

Genome-wide whole blood transcriptome profiling in a large European cohort of systemic sclerosis patients

Lorenzo Beretta, Guillermo Barturen, Barbara Vigone, Chiara Bellocchi, Nicolas Hunzelmann, Ellen De Langhe, Ricard Cervera, Maria Gerosa, László Kovács, Rafaela Ortega Castro, Isabel Almeida, Divi Cornec, Carlo Chizzolini, Jacques-Olivier Pers, Zuzanna Makowska, Ralf Lesche, Martin Kerick, Marta Eugenia Alarcón-Riquelme, Javier Martin, PRECISESADS SSc substudy group, PRECISESADS SSc substudy group, Doreen Belz, Eduardo Collantes-Estevez, Francesca Ingegnoli, Yolanda Jimenez Gómez, Chary Lopez Pedrera, Rik Lories, Gaia Montanelli, Silvia Piantoni, Ignasi Rodriguez Pinto, Carlos Vasconcelos, PRECISESADS Flow Cytometry study group, Christophe Jamin, Concepción Marañón, Lucas Le Lann, Quentin Simon, Bénédicte Rouvière, Nieves Varela, Brian Muchmore, Aleksandra Dufour, Montserrat Alvarez, Jonathan Cremer, Nuria Barbarroja, Velia Gerl, Laleh Khodadadi, Qingyu Cheng, Anne Buttgereit, Aurélie De Groof, Julie Ducreux, Elena Trombetta, Tianlu Li, Damiana Alvarez-Errico, Torsten Witte, Katja Kniesch, Nancy Azevedo, Esmeralda Neves, Sambasiva Rao, Pierre-Emmanuel Jouve

10.1136/annrheumdis-2020-217116

June 19, 2020

PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis

Yun Zhang, Lichong Shen, Honglin Zhu, Katja Dreissigacker, Diana Distler, Xiang Zhou, Andrea Hermina Györfi, Christina Bergmann, Xianyi Meng, Clara Dees, Thuong Trinh-Minh, Ingo Ludolph, Raymund Horch, Andreas Ramming, Georg Schett, Jörg H W Distler

10.1136/annrheumdis-2020-216963

June 1, 2020

Predictive factors for treatment-related mortality and major adverse events after autologous haematopoietic stem cell transplantation for systemic sclerosis: results of a long-term follow-up multicentre study

Sandra van Bijnen, Jeska de Vries-Bouwstra, Cornelia H van den Ende, Maaike Boonstra, Lucie Kroft, Bram Geurts, Miranda Snoeren, Anne Schouffoer, Julia Spierings, Jacob M van Laar, Tom WJ Huizinga, Alexandre Voskuyl, Erik Marijt, Walter van der Velden, Frank HJ van den Hoogen, Madelon C Vonk

10.1136/annrheumdis-2020-217058

May 14, 2020

Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH

Christopher W Wasson, Giuseppina Abignano, Heidi Hermes, Maya Malaab, Rebecca L Ross, Sergio A Jimenez, Howard Y Chang, Carol A Feghali-Bostwick, Francesco del Galdo

10.1136/annrheumdis-2019-216542

February 10, 2020

Haemodynamic phenotypes and survival in patients with systemic sclerosis: the impact of the new definition of pulmonary arterial hypertension

Panagiota Xanthouli, Suzana Jordan, Nicklas Milde, Alberto Marra, Norbert Blank, Benjamin Egenlauf, Matthias Gorenflo, Satenik Harutyunova, Hanns-Martin Lorenz, Christian Nagel, Vivienne Theobald, Mona Lichtblau, Charlotte Berlier, Silvia Ulrich, Ekkehard Grünig, Nicola Benjamin, Oliver Distler

10.1136/annrheumdis-2019-216476

December 9, 2019

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

Brian Skaug, Dinesh Khanna, William R Swindell, Monique E Hinchcliff, Tracy M Frech, Virginia D Steen, Faye N Hant, Jessica K Gordon, Ami A Shah, Lisha Zhu, W Jim Zheng, Jeffrey L Browning, Alexander M S Barron, Minghua Wu, Sudha Visvanathan, Patrick Baum, Jennifer M Franks, Michael L Whitfield, Victoria K Shanmugam, Robyn T Domsic, Flavia V Castelino, Elana J Bernstein, Nancy Wareing, Marka A Lyons, Jun Ying, Julio Charles, Maureen D Mayes, Shervin Assassi

10.1136/annrheumdis-2019-215894

November 25, 2019

Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs

Alexandru-Emil Matei, Chih-Wei Chen, Lisa Kiesewetter, Andrea-Hermina Györfi, Yi-Nan Li, Thuong Trinh-Minh, Xiaohan Xu, Cuong Tran Manh, Toin van Kuppevelt, Jan Hansmann, Astrid Jüngel, Georg Schett, Florian Groeber-Becker, Jörg H W Distler

10.1136/annrheumdis-2019-216108

September 20, 2019

Interferon regulatory factor 7 (IRF7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis

Minghua Wu, Brian Skaug, Xiongjie Bi, Tingting Mills, Gloria Salazar, Xiaodong Zhou, John Reveille, Sandeep K Agarwal, Michael R Blackburn, Maureen D Mayes, Shervin Assassi

10.1136/annrheumdis-2019-215208

August 22, 2019