Combined inhibition of IL-1, IL-33 and IL-36 signalling by targeting IL1RAP ameliorates skin and lung fibrosis in preclinical models of systemic sclerosisCaitríona Grönberg, Sara Rattik, Cuong Tran-Manh, Xiang Zhou, Aleix Rius Rigau, Yi-Nan Li, Andrea-Hermina Györfi, Nicholas Dickel, Meik Kunz, Alexander Kreuter, Emil-Alexandru Matei, Honglin Zhu, Petter Skoog, David Liberg, Jörg HW DistlerSee the full list of authors
9 April 2024
CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletionTheodoros Ioannis Papadimitriou, Prashant Singh, Arjan van Caam, Birgitte Walgreen, Mark A J Gorris, Elly L Vitters, Iris L van Ingen, Marije I Koenders, Ruben L Smeets, Madelon Vonk, Jolanda M de Vries, Peter M van der Kraan, Ypke van Oosterhout, Martijn A Huynen, Hans J P M KoenenSee the full list of authors
18 December 2023
Single-cell analysis reveals key differences between early-stage and late-stage systemic sclerosis skin across autoantibody subgroupsKristina Elizabeth Neergaard Clark, Shiwen Xu, Moustafa Attah, Voon H Ong, Christopher Dominic Buckley, Christopher P Denton
14 August 2023
Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantationBurcu Ayoglu, Michele Donato, Daniel E Furst, Leslie J Crofford, Ellen Goldmuntz, Lynette Keyes-Elstein, Judith James, Susan Macwana, Maureen D Mayes, Peter McSweeney, Richard A Nash, Keith M Sullivan, Beverly Welch, Ashley Pinckney, Rong MaoSee the full list of authors
18 January 2023
Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysisSébastien Sanges, Lisa Rice, Ly Tu, Eleanor Valenzi, Jean-Luc Cracowski, David Montani, Julio C Mantero, Camille Ternynck, Guillemette Marot, Andreea M Bujor, Eric Hachulla, David Launay, Marc Humbert, Christophe Guignabert, Robert Lafyatis
5 December 2022
Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosisJulia Z Adamska, Amin Zia, Michelle S Bloom, Leslie J Crofford, Daniel E Furst, Ellen Goldmuntz, Lynette Keyes-Elstein, Maureen D Mayes, Peter McSweeney, Richard A Nash, Ashley Pinckney, Beverly Welch, Zelda Z Love, Keith M Sullivan, William Robinson
14 October 2022
Continued treatment with nintedanib in patients with systemic sclerosis-associated interstitial lung disease: data from SENSCIS-ONYannick Allanore, Madelon C Vonk, Oliver Distler, Arata Azuma, Maureen D Mayes, Martina Gahlemann, Alexandra James, Veronika Kohlbrenner, Margarida Alves, Dinesh Khanna, Kristin B Highland,
16 August 2022
Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarchingXiaoyang Yue, Junping Yin, Xiaoqing Wang, Harald Heidecke, Alexander Maximilian Hackel, Xiaoru Dong, Brigitte Kasper, Lifang Wen, Liang Zhang, Kai Schulze-Forster, Juliane Junker, Hanna Grasshoff, Antje Müller, Gerd Wallukat, Ingolf SchimkeSee the full list of authors
20 May 2022
Peripheral blood gene expression profiling shows predictive significance for response to mycophenolate in systemic sclerosis-related interstitial lung diseaseShervin Assassi, Elizabeth R Volkmann, W Jim Zheng, Xuan Wang, Holly Wilhalme, Marka A Lyons, Michael D Roth, Donald P Tashkin
21 February 2022
Large-scale analysis of longitudinal skin gene expression in systemic sclerosis reveals relationships of immune cell and fibroblast activity with skin thickness and a trend towards normalisation over timeBrian Skaug, Marka A Lyons, William R Swindell, Gloria A Salazar, Minghua Wu, Tuan M Tran, Julio Charles, Connor P Vershel, Maureen D Mayes, Shervin Assassi
22 December 2021
