Rheumatoid arthritis

Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial

René Westhovens, William F C Rigby, Désirée van der Heijde, Daniel W T Ching, William Stohl, Jonathan Kay, Arvind Chopra, Beatrix Bartok, Franziska Matzkies, Zhaoyu Yin, Ying Guo, Chantal Tasset, John S Sundy, Angelika Jahreis, Neelufar Mozaffarian, Osvaldo Daniel Messina, Robert BM Landewé, Tatsuya Atsumi, Gerd R Burmester

10.1136/annrheumdis-2020-219213

January 15, 2021

Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4 T cells through differential DNA methylation, explaining a substantial proportion of heritability

Eunji Ha, So-Young Bang, Jiwoo Lim, Jun Ho Yun, Jeong-Min Kim, Jae-Bum Bae, Hye-Soon Lee, Bong-Jo Kim, Kwangwoo Kim, Sang-Cheol Bae

10.1136/annrheumdis-2020-219152

January 12, 2021

Disease activity, cytokines, chemokines and the risk of incident diabetes in rheumatoid arthritis

Joshua F Baker, Bryant R England, Michael George, Grant Cannon, Brian Sauer, Alexis Ogdie, Bartlett C Hamilton, Carlos Hunter, Michael J Duryee, Geoffrey Thiele, Ted R Mikuls

10.1136/annrheumdis-2020-219140

January 4, 2021

species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice

Rabia Moentadj, Yiwen Wang, Kate Bowerman, Linda Rehaume, Hendrik Nel, Paraic O Cuiv, Juliette Stephens, Amalina Baharom, Muralidhara Maradana, Vanessa Lakis, Mark Morrison, Timothy Wells, Philip Hugenholtz, Helen Benham, Kim-Anh Le Cao, Ranjeny Thomas

10.1136/annrheumdis-2020-219009

January 4, 2021

Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 novel susceptibility loci

Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim

10.1136/annrheumdis-2020-219065

December 11, 2020

Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study

Shahab Abtahi, Johanna H M Driessen, Andrea M Burden, Patrick C Souverein, Joop P van den Bergh, Tjeerd P van Staa, Annelies Boonen, Frank de Vries

10.1136/annrheumdis-2020-218758

December 11, 2020

Switching between Janus kinase inhibitor upadacitinib and adalimumab following insufficient response: efficacy and safety in patients with rheumatoid arthritis

Roy M Fleischmann, Ricardo Blanco, Stephen Hall, Glen T D Thomson, Filip E Van den Bosch, Cristiano Zerbini, Louis Bessette, Jeffrey Enejosa, Yihan Li, Yanna Song, Ryan DeMasi, In-Ho Song

10.1136/annrheumdis-2020-218412

November 4, 2020

Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis

Darja Andreev, Mengdan Liu, Katerina Kachler, Mireia Llerins Perez, Philipp Kirchner, Julia Kölle, Andreas Gießl, Simon Rauber, Rui Song, Oliver Aust, Anika Grüneboom, Arnd Kleyer, Juan D Cañete, Arif Ekici, Andreas Ramming, Susetta Finotto, Georg Schett, Aline Bozec

10.1136/annrheumdis-2020-218902

November 4, 2020

Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

Haruka Tsuchiya, Mineto Ota, Shuji Sumitomo, Kazuyoshi Ishigaki, Akari Suzuki, Toyonori Sakata, Yumi Tsuchida, Hiroshi Inui, Jun Hirose, Yuta Kochi, Yuho Kadono, Katsuhiko Shirahige, Sakae Tanaka, Kazuhiko Yamamoto, Keishi Fujio

10.1136/annrheumdis-2020-218189

November 2, 2020

Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme

Stanley B Cohen, Ronald F van Vollenhoven, Kevin L Winthrop, Cristiano A F Zerbini, Yoshiya Tanaka, Louis Bessette, Ying Zhang, Nasser Khan, Barbara Hendrickson, Jeffrey V Enejosa, Gerd R Burmester

10.1136/annrheumdis-2020-218510

October 28, 2020