Rheumatoid arthritis

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saedis Saevarsdottir, Lilja Stefansdottir, Patrick Sulem, Gudmar Thorleifsson, Egil Ferkingstad, Gudrun Rutsdottir, Bente Glintborg, Helga Westerlind, Gerdur Grondal, Isabella C Loft, Signe Bek Sorensen, Benedicte A Lie, Mikael Brink, Lisbeth Ärlestig, Asgeir Orn Arnthorsson, Eva Baecklund, Karina Banasik, Steffen Bank, Lena I Bjorkman, Torkell Ellingsen, Christian Erikstrup, Oleksandr Frei, Inger Gjertsson, Daniel F Gudbjartsson, Sigurjon A Gudjonsson, Gisli H Halldorsson, Oliver Hendricks, Jan Hillert, Estrid Hogdall, Søren Jacobsen, Dorte Vendelbo Jensen, Helgi Jonsson, Alf Kastbom, Ingrid Kockum, Salome Kristensen, Helga Kristjansdottir, Margit H Larsen, Asta Linauskas, Ellen-Margrethe Hauge, Anne G Loft, Bjorn R Ludviksson, Sigrun H Lund, Thorsteinn Markusson, Gisli Masson, Pall Melsted, Kristjan H S Moore, Heidi Munk, Kaspar R Nielsen, Gudmundur L Norddahl, Asmundur Oddsson, Thorunn A Olafsdottir, Pall I Olason, Tomas Olsson, Sisse Rye Ostrowski, Kim Hørslev-Petersen, Solvi Rognvaldsson, Helga Sanner, Gilad N Silberberg, Hreinn Stefansson, Erik Sørensen, Inge J Sørensen, Carl Turesson, Thomas Bergman, Lars Alfredsson, Tore K Kvien, Søren Brunak, Kristján Steinsson, Vibeke Andersen, Ole A Andreassen, Solbritt Rantapää-Dahlqvist, Merete Lund Hetland, Lars Klareskog, Johan Askling, Leonid Padyukov, Ole BV Pedersen, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson, Members of the DBDS Genomic Consortium, The Danish RA Genetics Working Group, Members of the DBDS Genomic Consortium, Steffen Andersen, Karina Banasik, Søren Brunak, Kristoffer Burgdorf, Christian Erikstrup, Thomas Folkmann Hansen, Henrik Hjalgrim, Gregor Jemec, Poul Jennum, Pär Ingemar Johansson, Kasper Rene Nielsen, Mette Nyegaard, Mie Topholm Brun, Ole Birger Pedersen, Susan Mikkelsen, Khoa Manh Dinh, Erik Sørensen, Henrik Ullum, Sisse Rye Ostrowski, Thomas Werge, Daniel Gudbjartsson, Kari Stefansson, Hreinn Stefánsson, Unnur Þorsteinsdóttir, Margit Anita Hørup Larsen, Maria Didriksen, Susanne Sækmose, The Danish RA Genetics Working Group, Paal Skytt Andersen, Ram Benny Dessau, Malene Rohr Andersen, Hans Jürgen Hoffmann, Claus Lohman Brasen, The Swedish Rheumatology Quality Register Biobank Study Group (SRQb), Johan Askling, Eva Baecklund, Lena Bjorkman, Alf Kastbom, Solbritt Rantapaa-Dahlqvist, Carl Turesson

10.1136/annrheumdis-2021-221754

April 25, 2022

Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis

Jaxaira Maggi, Montserrat Carrascal, Lilian Soto, Oscar Neira, María C Cuéllar, Octavio Aravena, Eddie A James, Joaquin Abian, Dolores Jaraquemada, Diego Catalan, Juan C Aguillón

10.1136/annrheumdis-2021-220371

April 22, 2022

Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis

Vanessa Waltereit-Kracke, Corinna Wehmeyer, Denise Beckmann, Eugenie Werbenko, Julia Reinhardt, Fabienne Geers, Mike Dienstbier, Michelle Fennen, Johanna Intemann, Peter Paruzel, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar

10.1136/annrheumdis-2021-221409

April 13, 2022

Short-term, intermediate-term and long-term risks of acute coronary syndrome in cohorts of patients with RA starting biologic DMARDs: results from four Nordic countries

Benedicte Delcoigne, Lotta Ljung, Sella A Provan, Bente Glintborg, Merete Lund Hetland, Kathrine Lederballe Grøn, Ritva Peltomaa, Heikki Relas, Carl Turesson, Bjorn Gudbjornsson, Brigitte Michelsen, Johan Askling

10.1136/annrheumdis-2021-221996

March 22, 2022

Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial

Carlo Scognamiglio Renner Araujo, Ana Cristina Medeiros-Ribeiro, Carla G S Saad, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Matheus Santos Rodrigues Silva, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Tatiana Pedrosa, Leonard de Vinci Kanda Kupa, Gioanna Zou, Rosa M R Pereira, Clóvis Artur Silva, Nádia Emi Aikawa, Eloisa Bonfa

10.1136/annrheumdis-2021-221916

February 22, 2022

Baricitinib further enhances disease-modifying effects by uncoupling the link between disease activity and joint structural progression in patients with rheumatoid arthritis

Pedro Lopez-Romero, Inmaculada de la Torre, Ewa Haladyj, Daniel Aletaha, Josef S Smolen

10.1136/annrheumdis-2021-221323

February 22, 2022

Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis

Ana Cristina Medeiros-Ribeiro, Karina Rossi Bonfiglioli, Diogo Souza Domiciano, Andrea Yukie Shimabuco, Henrique Carriço da Silva, Carla G S Saad, Emily Figueiredo Neves Yuki, Sandra Gofinet Pasoto, Carlo Scognamiglio Renner Araujo, Tatiane Lie Nakai, Clóvis Artur Silva, Tatiana Pedrosa, Léonard de Vinci Kanda Kupa, Matheus Santos Rodrigues Silva, Guilherme Guimarães Moreira Balbi, Esper Georges Kallas, Nádia Emi Aikawa, Eloisa Bonfa

10.1136/annrheumdis-2021-221735

February 8, 2022

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

Changrong Ge, Sylvia Weisse, Bingze Xu, Doreen Dobritzsch, Johan Viljanen, Jan Kihlberg, Nhu-Nguyen Do, Nadine Schneider, Harald Lanig, Rikard Holmdahl, Harald Burkhardt

10.1136/annrheumdis-2021-220500

January 13, 2022

Tofacitinib and risk of cardiovascular outcomes: results from the Safety of TofAcitinib in Routine care patients with Rheumatoid Arthritis (STAR-RA) study

Farzin Khosrow-Khavar, Seoyoung C Kim, Hemin Lee, Su Been Lee, Rishi J Desai

10.1136/annrheumdis-2021-221915

January 13, 2022

Multilevel factors predict medication adherence in rheumatoid arthritis: a 6-month cohort study

Alejandro Balsa, Maria Jesus García de Yébenes, Loreto Carmona, ADHIERA Study Group, Laura Garrido Courel, Javier Mendizábal, Juliana Restrepo, Dolores Fábregas, Joana Atxotegi Saenz de Buruaga, Javier Duruelo Etxebarrieta, Nathali Rivas Zavaleta, Eugenio Chamizo Carmona, Lara Chaves, Sara Rojas, Francisca Sivera, Laura Casas Hernández, Beatriz González Álvarez, Antonio Gómez Centeno, Eduard Graell, Mercedes Alperi, Susana Holgado, Melania Martinez Morillo, Fermín Medina Varo, Alba Pérez Linaza, Isabel Serrano García

10.1136/annrheumdis-2021-221163

November 29, 2021