Osteoarthritis

Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis

Manabu Kawata, Takeshi Teramura, Philip Ordoukhanian, Steven R Head, Padmaja Natarajan, Aishwarya Sundaresan, Merissa Olmer, Hiroshi Asahara, Martin K Lotz

10.1136/annrheumdis-2021-221867

May 9, 2022

Osteoarthritis endotype discovery via clustering of biochemical marker data

Federico Angelini, Paweł Widera, Ali Mobasheri, Joseph Blair, André Struglics, Melanie Uebelhoer, Yves Henrotin, Anne CA Marijnissen, Margreet Kloppenburg, Francisco J Blanco, Ida K Haugen, Francis Berenbaum, Christoph Ladel, Jonathan Larkin, Anne C Bay-Jensen, Jaume Bacardit

10.1136/annrheumdis-2021-221763

March 4, 2022

Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7

Haiyan Zhang, Yan Shao, Zihao Yao, Liangliang Liu, Hongbo Zhang, Jianbin Yin, Haoyu Xie, Kai Li, Pinglin Lai, Hua Zeng, Guozhi Xiao, Chun Zeng, Daozhang Cai, Xiaochun Bai

10.1136/annrheumdis-2021-221513

January 20, 2022

Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis

Kai-di Wang, Xiang Ding, Nan Jiang, Chao Zeng, Jing Wu, Xian-yi Cai, Aubryanna Hettinghouse, Asya Khleborodova, Zi-Ning Lei, Zhe-Sheng Chen, Guang-hua Lei, Chuan-ju Liu

10.1136/annrheumdis-2021-221380

December 1, 2021

Exercise and education versus saline injections for knee osteoarthritis: a randomised controlled equivalence trial

Elisabeth Bandak, Robin Christensen, Anders Overgaard, Lars Erik Kristensen, Karen Ellegaard, Jørgen Guldberg-Møller, Cecilie Bartholdy, David J Hunter, Roy Altman, Henning Bliddal, Marius Henriksen

10.1136/annrheumdis-2021-221129

November 29, 2021

METTL3-mediated mA modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression

Xiang Chen, Wang Gong, Xiaoyan Shao, Tianshu Shi, Lei Zhang, Jian Dong, Yong Shi, Siyu Shen, Jianghui Qin, Qing Jiang, Baosheng Guo

10.1136/annrheumdis-2021-221091

October 27, 2021

14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis

Wenyu Fu, Aubryanna Hettinghouse, Yujianan Chen, Wenhuo Hu, Xiang Ding, Meng Chen, Yuanjing Ding, Jyoti Mundra, Wenhao Song, Ronghan Liu, Young-Su Yi, Mukundan Attur, Jonathan Samuels, Eric Strauss, Philipp Leucht, Ran Schwarzkopf, Chuan-ju Liu

10.1136/annrheumdis-2021-220000

July 5, 2021

circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1

Shuying Shen, Yute Yang, Panyang Shen, Jun Ma, Bin Fang, Qingxin Wang, Kefan Wang, Peihua Shi, Shunwu Fan, Xiangqian Fang

10.1136/annrheumdis-2021-219969

May 26, 2021

Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study

Felix Eckstein, Marc C Hochberg, Hans Guehring, Flavie Moreau, Victor Ona, Asger Reinstrup Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Benjamin Daelken, Oliver Guenther, Christoph Ladel, Martin Michaelis, Philip G Conaghan

10.1136/annrheumdis-2020-219181

May 7, 2021

Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis

Julia Steinberg, Lorraine Southam, Andreas Fontalis, Matthew J Clark, Raveen L Jayasuriya, Diane Swift, Karan M Shah, Roger A Brooks, Andrew W McCaskie, Jeremy Mark Wilkinson, Eleftheria Zeggini

10.1136/annrheumdis-2020-219760

April 26, 2021