BCMA-CD19 compound CAR T cells for systemic lupus erythematosus: a phase 1 open-label clinical trialWeijia Wang, Shanzhi He, Wenli Zhang, Hongyu Zhang, Vincent M DeStefano, Masayuki Wada, Kevin Pinz, Greg Deener, Darshi Shah, Nabil Hagag, Min Wang, Ming Hong, Ronghao Zeng, Ting Lan, Yu MaSee the full list of authors
22 May 2024
Remission and low disease activity are associated with lower healthcare costs: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohortMegan R W Barber, Manuel Francisco Ugarte-Gil, John G Hanly, Murray B Urowitz, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J Wallace, David A Isenberg, Anisur Rahman, Joan T Merrill, Paul R FortinSee the full list of authors
16 May 2024
Haematopoietic stem cell-derived immune cells have reduced X chromosome inactivation skewing in systemic lupus erythematosusAmy L Roberts, Alessandro Morea, Ariella Amar, Magdalena West, Sarah Karrar, Rhiannon Lehane, Philip Tombleson, Deborah Cunningham Grahman, John A Reynolds, Chloe C Y Wong, David L Morris, Kerrin S Small, Timothy J Vyse
27 June 2024
Blood RNA-sequencing across the continuum of ANA-positive autoimmunity reveals insights into initiating immunopathologyLucy Marie Carter, Md Yuzaiful Md Yusof, Zoe Wigston, Darren Plant, Stephanie Wenlock, Adewonuola Alase, Antonios Psarras, Edward M Vital
13 May 2024
Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort studyYasuhiro Katsumata, Eisuke Inoue, Masayoshi Harigai, Jiacai Cho, Worawit Louthrenoo, Alberta Hoi, Vera Golder, Chak Sing Lau, Aisha Lateef, Yi-Hsing Chen, Shue-Fen Luo, Yeong-Jian Jan Wu, Laniyati Hamijoyo, Zhanguo Li, Sargunan SockalingamSee the full list of authors
29 February 2024
Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trialsTina Baker, Hoda Sharifian, Paul J Newcombe, Patrick G Gavin, Mark N Lazarus, Madhu Ramaswamy, Wendy I White, Nicola Ferrari, Daniel Muthas, Raj Tummala, Eric F Morand, Richard A Furie, Edward M Vital, Chris Chamberlain, Adam PlattSee the full list of authors
3 April 2024
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupusErica Moore, Sushma Bharrhan, Deepak A Rao, Fernando Macian, Chaim Putterman
26 March 2024
Disease activity drives divergent epigenetic and transcriptomic reprogramming of monocyte subpopulations in systemic lupus erythematosusAnna Guiomar Ferreté-Bonastre, Mónica Martínez-Gallo, Octavio Morante-Palacios, Celia Lourdes Calvillo, Josep Calafell-Segura, Javier Rodríguez-Ubreva, Manel Esteller, Josefina Cortés-Hernández, Esteban Ballestar
27 February 2024
KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasisManish Kumar Singh, Harikrishna Reddy Rallabandi, Xu-Jie Zhou, Yuan-Yuan Qi, Zhan-Zheng Zhao, Ting Gan, Hong Zhang, Loren L Looger, Swapan K Nath
19 February 2024
Molecular characterisation of lupus low disease activity state (LLDAS) and DORIS remission by whole-blood transcriptome-based pathways in a pan-European systemic lupus erythematosus cohortIoannis Parodis, Julius Lindblom, Guillermo Barturen, Rafaela Ortega-Castro, Ricard Cervera, Jacques-Olivier Pers, Fernanda Genre, Falk Hiepe, Maria Gerosa, László Kovács, Ellen De Langhe, Silvia Piantoni, Georg Stummvoll, Carlos Vasconcelos, Barbara VigoneSee the full list of authors
19 February 2024