Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants
…, CA Gleason, EM Bifano, DD Millard, CB Davis… - …, 1995 - publications.aap.org
Design and methods. We hypothesized that treatment with recombinant human erythropoietin
(r-HuEPO) would stimulate erythropoiesis and would thereby reduce the need for …
(r-HuEPO) would stimulate erythropoiesis and would thereby reduce the need for …
Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry
An enzyme- and click chemistry-mediated methodology for the site-selective radiolabeling
of antibodies on the heavy chain glycans has been developed and validated. To this end, a …
of antibodies on the heavy chain glycans has been developed and validated. To this end, a …
Chemoenzymatic strategy for the synthesis of site-specifically labeled immunoconjugates for multimodal PET and optical imaging
The complementary nature of positron emission tomography (PET) and optical imaging (OI)
has fueled increasing interest in the development of multimodal PET/OI probes that can be …
has fueled increasing interest in the development of multimodal PET/OI probes that can be …
Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century
…, S Hindley, RB Bambal, CB Davis… - Journal of medicinal …, 2009 - ACS Publications
N-tert-Butyl isoquine (4) (GSK369796) is a 4-aminoquinoline drug candidate selected and
developed as part of a public−private partnership between academics at Liverpool, MMV, and …
developed as part of a public−private partnership between academics at Liverpool, MMV, and …
A population pharmacokinetic‐pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis
DR Mould, CB Davis, EA Minthorn… - Clinical …, 1999 - Wiley Online Library
Clenoliximab (IDEC‐151) is a macaque‐human chimeric monoclonal antibody (immunoglobulin
G4) specific for the CD4 molecule on the surface of T lymphocytes. It is being studied in …
G4) specific for the CD4 molecule on the surface of T lymphocytes. It is being studied in …
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4′-fluoro and 4′-chloro analogues of amodiaquine. Identification of a suitable “ …
…, S Hindley, RB Bambal, CB Davis… - Journal of medicinal …, 2009 - ACS Publications
On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline
amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-…
amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-…
Differences in effects on myocardium and mitochondria by angiogenic inhibitors suggest separate mechanisms of cardiotoxicity
…, TL Gales, S Zhao, LM Storck, CB Davis… - Toxicologic …, 2010 - journals.sagepub.com
Several multikinase angiogenesis inhibitors demonstrate mitochondrial and/or cardiovascular
toxicity, suggesting an on-target pharmacologic effect. To evaluate whether cardiotoxicity …
toxicity, suggesting an on-target pharmacologic effect. To evaluate whether cardiotoxicity …
The influence of ionic strength on the binding of a water soluble porphyrin to nucleic acids
The ionic strength dependences of the binding of tetrakis (4-N-methypyridyl)porphine (H 2
TMpyP) to poly(dG-dC) and calf thymus DNA have been determined. For the former system …
TMpyP) to poly(dG-dC) and calf thymus DNA have been determined. For the former system …
[HTML][HTML] Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials
…, B Kitchell, C Kingsley, S Kim, M Neff, B Davis… - PLoS …, 2014 - journals.plos.org
Background Molecularly-guided trials (ie PMed) now seek to aid clinical decision-making by
matching cancer targets with therapeutic options. Progress has been hampered by the lack …
matching cancer targets with therapeutic options. Progress has been hampered by the lack …
Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys
…, FS Chow, LP Tobia, DC Kwok, CB Davis… - … of Pharmacology and …, 2000 - ASPET
The pharmacokinetics and pharmacodynamics (PK/PD) of a humanized anti-Factor IX IgG1
monoclonal antibody (SB 249417, FIX mAb) were studied in Cynomolgus monkeys. Single iv …
monoclonal antibody (SB 249417, FIX mAb) were studied in Cynomolgus monkeys. Single iv …