In the review, topical aspects of the study of antinuclear antibodies (ANA) in systemic lupus
erythematosus (SLE) are considered. ANA is the main serological marker of SLE. In the sera …

Background Our aim was to compare serum levels of cytokines in patients with systemic
lupus erythematosus (SLE) and rheumatoid arthritis (RA). Objectives Comparative data on …

Background Autoantibodies against intracellular antigens are a serological hallmark of ANA-
associated systemic autoimmune rheumatic diseases (AARD) such as SLE. IIF on HEp-2 …

Background. The clinical and serologic heterogeneity of systemic lupus erythematosus
(SLE) presents challenges for diagnosis, particularly in the earliest stages of the disease …

Background Diagnosis of antiphospholipid syndrome (APS) still remains a laboratory
challenge due to the great diversity of antiphospholipid antibodies (aPL) and their …

A promising trend in the diagnosis of systemic autoimmune diseases is the multiplex
immune assay (MIA) of autoantibodies and other laboratory biomarkers using microchips …

Background The prevalence of anti-DFS70 antibodies in healthy volunteers (HV) by various
methods ranges from 0 to 22%[1]. This pattern, which is rare in patients with systemic …

Background Double-strand DNA breaks (DNA-DSB) are one of the most biologically
significant DNA damage lesions that leads to chromosome breakage and/or rearrangement …

Background ANA–heterogeneous group of autoantibodies, reacting with the different
components of nucleus and cytoplasm. ANA is main serological marker SLE and others …

Background ANA are a diagnostic hallmark of SLE and others systemic autoimmune
rheumatic diseases (SARD). Different methods have recently been developed for automated …