User profiles for "author:Yusuke Takeshima"

Yusuke Takeshima

Osaka Univ.
Verified email at umin.ac.jp
Cited by 706

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

EP Mimitou, CA Lareau, KY Chen… - Nature …, 2021 - nature.com
Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

[PDF][PDF] Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases

M Ota, Y Nagafuchi, H Hatano, K Ishigaki, C Terao… - Cell, 2021 - cell.com
Genetic studies have revealed many variant loci that are associated with immune-mediated
diseases. To elucidate the disease pathogenesis, it is essential to understand the function of …

[HTML][HTML] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

R Edahiro, Y Shirai, Y Takeshima, S Sakakibara… - Nature …, 2023 - nature.com
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …

Basic mechanism of immune system activation by mitochondria

Y Iwasaki, Y Takeshima, K Fujio - Immunological medicine, 2020 - Taylor & Francis
Almost 160 years after the discovery of mitochondria, they are known for their production of
energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been …

Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus

Y Takeshima, Y Iwasaki, K Fujio… - Seminars in Arthritis and …, 2019 - Elsevier
In the middle of the 20th century, biologists focused on investigating the mechanism of gene
regulation and signal transduction in cells, which led to the concept that metabolites were …

[PDF][PDF] Distinct transcriptome architectures underlying lupus establishment and exacerbation

M Nakano, M Ota, Y Takeshima, Y Iwasaki, H Hatano… - Cell, 2022 - cell.com
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …

[HTML][HTML] Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Y Yasumizu, N Ohkura, H Murata, M Kinoshita… - Nature …, 2022 - nature.com
Myasthenia gravis (MG) is a neurological disease caused by autoantibodies against
neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the …

[HTML][HTML] Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells

Y Yamaguchi, Y Kato, R Edahiro, JN Søndergaard… - Jci Insight, 2022 - ncbi.nlm.nih.gov
Consecutive mRNA vaccinations against SARS-CoV-2 reinforced both innate and adaptive
immune responses. However, it remains unclear whether the enhanced innate immune …

Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus

Y Takeshima, Y Iwasaki, M Nakano… - Annals of the …, 2022 - ard.bmj.com
Objective Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune
disease. While the long-term prognosis has greatly improved, better long-term survival is still …

Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis

S Kobayashi, Y Nagafuchi, M Okubo, Y Sugimori… - Journal of …, 2021 - Elsevier
Objective Immunological disturbances have been reported in systemic sclerosis (SSc). This
study assessed the transcriptome disturbances in immune cell subsets in SSc and …