User profiles for "author:Yusuke Takeshima"
Yusuke TakeshimaOsaka Univ. Verified email at umin.ac.jp Cited by 706 |
Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells
EP Mimitou, CA Lareau, KY Chen… - Nature …, 2021 - nature.com
Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …
[PDF][PDF] Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases
Genetic studies have revealed many variant loci that are associated with immune-mediated
diseases. To elucidate the disease pathogenesis, it is essential to understand the function of …
diseases. To elucidate the disease pathogenesis, it is essential to understand the function of …
[HTML][HTML] Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
R Edahiro, Y Shirai, Y Takeshima, S Sakakibara… - Nature …, 2023 - nature.com
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …
syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T …
Basic mechanism of immune system activation by mitochondria
Y Iwasaki, Y Takeshima, K Fujio - Immunological medicine, 2020 - Taylor & Francis
Almost 160 years after the discovery of mitochondria, they are known for their production of
energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been …
energy and are called “the powerhouse of the cell”. Recently, immune-metabolism has been …
Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus
Y Takeshima, Y Iwasaki, K Fujio… - Seminars in Arthritis and …, 2019 - Elsevier
In the middle of the 20th century, biologists focused on investigating the mechanism of gene
regulation and signal transduction in cells, which led to the concept that metabolites were …
regulation and signal transduction in cells, which led to the concept that metabolites were …
[PDF][PDF] Distinct transcriptome architectures underlying lupus establishment and exacerbation
M Nakano, M Ota, Y Takeshima, Y Iwasaki, H Hatano… - Cell, 2022 - cell.com
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …
[HTML][HTML] Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
Y Yasumizu, N Ohkura, H Murata, M Kinoshita… - Nature …, 2022 - nature.com
Myasthenia gravis (MG) is a neurological disease caused by autoantibodies against
neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the …
neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the …
[HTML][HTML] Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells
Y Yamaguchi, Y Kato, R Edahiro, JN Søndergaard… - Jci Insight, 2022 - ncbi.nlm.nih.gov
Consecutive mRNA vaccinations against SARS-CoV-2 reinforced both innate and adaptive
immune responses. However, it remains unclear whether the enhanced innate immune …
immune responses. However, it remains unclear whether the enhanced innate immune …
Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus
Y Takeshima, Y Iwasaki, M Nakano… - Annals of the …, 2022 - ard.bmj.com
Objective Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune
disease. While the long-term prognosis has greatly improved, better long-term survival is still …
disease. While the long-term prognosis has greatly improved, better long-term survival is still …
Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis
S Kobayashi, Y Nagafuchi, M Okubo, Y Sugimori… - Journal of …, 2021 - Elsevier
Objective Immunological disturbances have been reported in systemic sclerosis (SSc). This
study assessed the transcriptome disturbances in immune cell subsets in SSc and …
study assessed the transcriptome disturbances in immune cell subsets in SSc and …