Oxidative stress and metal carcinogenesis

JC Lee, YO Son, P Pratheeshkumar, X Shi - Free radical biology and …, 2012 - Elsevier
Occupational and environmental exposures to metals are closely associated with an
increased risk of various cancers. Although carcinogenesis caused by metals has been …

Cancer prevention with promising natural products: mechanisms of action and molecular targets

P Pratheeshkumar, C Sreekala, Z Zhang… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer is the second leading cause of death worldwide. There is greater need for more
effective and less toxic therapeutic and preventive strategies. Natural products are becoming …

[HTML][HTML] Metal-based nanoparticles and their relevant consequences on cytotoxicity cascade and induced oxidative stress

Y Min, GGD Suminda, Y Heo, M Kim, M Ghosh, YO Son - Antioxidants, 2023 - mdpi.com
Emerging nanoscience allows us to take advantage of the improved evolutionary
components and apply today's advanced characterization and fabrication techniques to …

[HTML][HTML] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR-2 regulated AKT/mTOR/P70S6K signaling pathways

P Pratheeshkumar, A Budhraja, YO Son, X Wang… - 2012 - journals.plos.org
Angiogenesis is a crucial step in the growth and metastasis of cancers, since it enables the
growing tumor to receive oxygen and nutrients. Cancer prevention using natural products …

The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis

WS Choi, G Lee, WH Song, JT Koh, J Yang, JS Kwak… - Nature, 2019 - nature.com
Osteoarthritis—the most common form of age-related degenerative whole-joint disease—is
primarily characterized by cartilage destruction, as well as by synovial inflammation …

Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation

JY Kim, YO Son, SW Park, JH Bae, JS Chung… - … & molecular medicine, 2006 - nature.com
In this study, we have investigated if current cancer therapeutic modalities including
hyperthermia and ionizing radiation can increase the expression of NKG2D ligands in …

Quercitrin protects skin from UVB-induced oxidative damage

Y Yin, W Li, YO Son, L Sun, J Lu, D Kim, X Wang… - Toxicology and applied …, 2013 - Elsevier
Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin,
resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin …

Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells

YO Son, X Wang, JA Hitron, Z Zhang, S Cheng… - Toxicology and applied …, 2011 - Elsevier
Cadmium is a toxic heavy metal which is environmentally and occupationally relevant. The
mechanisms underlying cadmium-induced autophagy are not yet completely understood …

[HTML][HTML] Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis

P Pratheeshkumar, YO Son, A Budhraja, X Wang… - PloS one, 2012 - journals.plos.org
Angiogenesis, the formation of new blood vessels from pre-existing vascular beds, is
essential for tumor growth, invasion, and metastasis. Luteolin is a common dietary flavonoid …

Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling

YO Son, L Wang, P Poyil, A Budhraja, JA Hitron… - Toxicology and applied …, 2012 - Elsevier
Cadmium has been widely used in industry and is known to be carcinogenic to humans.
Although it is widely accepted that chronic exposure to cadmium increases the incidence of …