Tristetraprolin (TTP) is a well-characterized, zinc finger-containing, RNA-binding protein.
TTP targets tumor necrosis factor α for degradation via the 3′ untranslated region (3 …

An abnormal neutrophil subset has been identified in the PBMC fractions from lupus
patients. We have proposed that these low-density granulocytes (LDGs) play an important …

Neutrophil-specific genes are abundant in PBMC microarrays from lupus patients because
of the presence of low-density granulocytes (LDGs) in mononuclear cell fractions. The …

Rationale The structural and functional integrity of the endothelium is crucial in maintaining
vascular homeostasis and preventing atherosclerosis. Patients with systemic lupus …

Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage,
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in …

Objectives An imbalance between neutrophil extracellular trap (NET) formation and
degradation has been described in systemic lupus erythematosus (SLE), potentially …

Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation
activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We …

Objective Dysregulation of innate and adaptive immune responses contributes to the
pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular …

Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …

Objective Patients with systemic lupus erythematosus (SLE) have a notable increase in
atherothrombotic cardiovascular disease (CVD) which is not explained by the Framingham …