User profiles for "author:W OLLIER"

William Ollier

Professor of Immunogenetics, University of Manchester
Verified email at manchester.ac.uk
Cited by 47104

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

E Evangelou, HJ Kerkhof, U Styrkarsdottir… - Annals of the …, 2014 - ard.bmj.com
Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic
component. To identify novel loci associated with hip OA we performed a meta-analysis of …

Genetic markers of disease susceptibility and severity in giant cell arteritis and polymyalgia rheumatica

MA González-Gay, MM Amoli, C Garcia-Porrua… - Seminars in arthritis and …, 2003 - Elsevier
Background and Objectives: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR)
are common and often overlapping diseases that generally occur in elderly patients. In this …

Population genetics of rheumatoid arthritis

W Ollier, W Thomson - Rheumatic disease clinics of North America, 1992 - Elsevier
It is now a considerable number of years since the first report of an association between
rheumatoid arthritis (RA) and Dw4/DR4. 98, 99 In this timet the human leukocyte antigen …

Genome-wide association study identifies 74 loci associated with educational attainment

A Okbay, JP Beauchamp, MA Fontana, JJ Lee, TH Pers… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1 …

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

…, AK Malhotra, I Melle, D Morris, AC Need, W Ollier… - Nature …, 2018 - nature.com
Intelligence is highly heritable and a major determinant of human health and well-being.
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

Twin concordance rates for rheumatoid arthritis: results from a nationwide study

AJ Silman, AJ MacGregor, W Thomson… - …, 1993 - academic.oup.com
We report the concordance rate for RA in a nationwide study of 91 monozygotic (MZ) and
112 dizygotic (DZ) pairs. Twin pairs were recruited from both a national media campaign …

[PDF][PDF] Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

CG Boer, K Hatzikotoulas, L Southam, L Stefánsdóttir… - Cell, 2021 - cell.com
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

…, AC Need, R Noordam, L Nyberg, W Ollier… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

EF Remmers, F Cosan, Y Kirino, MJ Ombrello… - Nature …, 2010 - nature.com
Behçet's disease is a genetically complex disease of unknown etiology characterized by
recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed …

Genome-wide association studies establish that human intelligence is highly heritable and polygenic

…, I Reinvang, A Pickles, VM Steen, W Ollier… - Molecular …, 2011 - nature.com
General intelligence is an important human quantitative trait that accounts for much of the
variation in diverse cognitive abilities. Individual differences in intelligence are strongly …