Transfer of CD4+ T cells to immune‐deficient mice in the absence of the CD25+ subset
leads to the development of colitis, indicating that regulatory cells capable of controlling a …

Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating
evidence of pathogenic disease‐specific autoimmunity to citrullinated proteins. Citrullination …

Patients with rheumatoid arthritis can be divided into two major subsets characterized by the
presence versus absence of antibodies to citrullinated protein antigens (ACPAs) and of …

It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the
normal immune repertoire, preventing the development of pathogenic responses to both self …

In the homeostasis of the immune system regulatory cells play a major role. Removal of one
group of regulatory cells, the CD25+ CD4+ T cells, leads to autoimmune manifestations in …

The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune
regulation remains poorly understood. We have analyzed the functional role of CD103 in …

Abstract CD25+ CD4+ regulatory T cells participate in the regulation of immune responses.
We recently demonstrated the presence of CD25 bright CD4+ regulatory T cells with a …

Objectives Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies
(ACPAs) appear before disease onset and are associated with bone destruction. We aimed …

Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with
an association existing between smoking, HLA-DRB1'shared epitope'alleles, PTPN22 and …

A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how
systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive …