Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression
Z Brkic, NI Maria, CG van Helden-Meeuwsen… - Annals of the …, 2013 - ard.bmj.com
Objective To determine the prevalence of upregulation of interferon (IFN) type I inducible
genes, the so called 'IFN type I signature', in CD14 monocytes in 69 patients with primary …
genes, the so called 'IFN type I signature', in CD14 monocytes in 69 patients with primary …
A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome
Activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) is an inborn error of
immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity …
immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity …
The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and …
Z Brkic, L van Bon, M Cossu… - Annals of the …, 2016 - ard.bmj.com
Background Interferon (IFN) signature has been reported in definite systemic sclerosis (SSc)
but it has not been characterised in early SSc (EaSSc). We aim at characterising IFN type I …
but it has not been characterised in early SSc (EaSSc). We aim at characterising IFN type I …
[HTML][HTML] Altered peripheral blood compounds in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis
N Çakici, AL Sutterland, BWJH Penninx… - Brain, behavior, and …, 2020 - Elsevier
Importance Schizophrenia and major depressive disorder (MDD) are associated with
increased risks of immunologic disease and metabolic syndrome. It is unclear to what extent …
increased risks of immunologic disease and metabolic syndrome. It is unclear to what extent …
The role of cortistatin in the human immune system
Cortistatin (CST) is a recently described neuropeptide that shares high homology with
somatostatin (somatotropin release-inhibiting factor, SRIF) and binds with high affinity to all …
somatostatin (somatotropin release-inhibiting factor, SRIF) and binds with high affinity to all …
X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene
C Lagresle-Peyrou, S Luce, F Ouchani… - Journal of Allergy and …, 2016 - Elsevier
Background We investigated 7 male patients (from 5 different families) presenting with
profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and …
profound lymphopenia, hypogammaglobulinemia, fluctuating monocytopenia and …
Association of Increased Treg Cell Levels With Elevated Indoleamine 2, 3‐Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon‐Positive …
NI Maria, CG van Helden‐Meeuwsen… - Arthritis & …, 2016 - Wiley Online Library
Objective Indoleamine 2, 3‐dioxygenase (IDO), the rate‐limiting enzyme that converts
tryptophan to kynurenine, is driven in part by type I and type II interferons (IFNs). Naive T …
tryptophan to kynurenine, is driven in part by type I and type II interferons (IFNs). Naive T …
Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system
VA Dalm, PM van Hagen… - The Journal of …, 2003 - academic.oup.com
Cells of the human immune system have been shown to express somatostatin receptors
(sst). The expression of sst suggests a functional role of the peptide somatostatin (SS) …
(sst). The expression of sst suggests a functional role of the peptide somatostatin (SS) …
[HTML][HTML] T-helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?
Z Brkic, OBJ Corneth… - Arthritis Research & …, 2014 - Springer
Introduction A hallmark of systemic autoimmune diseases like systemic lupus erythematosus
(SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN …
(SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN …
[HTML][HTML] Interim analysis: open-label extension study of leniolisib for patients with APDS
Background Activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS; or p110δ-
activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency) is …
activating mutations causing senescent T cells, lymphadenopathy, and immunodeficiency) is …