The cannabinoid system and pain

SG Woodhams, V Chapman, DP Finn, AG Hohmann… - …, 2017 - Elsevier
Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

The role of the endocannabinoid system in pain

SG Woodhams, DR Sagar, JJ Burston, V Chapman - Pain control, 2015 - Springer
Preparations of the Cannabis sativa plant have been used to analgesic effect for millenia,
but only in recent decades has the endogenous system responsible for these effects been …

Cannabinoids: a real prospect for pain relief

L Iversen, V Chapman - Current opinion in pharmacology, 2002 - Elsevier
Research on the therapeutic potential of cannabinoids has grown dramatically over the past
few years. Recent advances include evidence that cannabinoid agonists are …

[HTML][HTML] Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

D Richardson, RG Pearson, N Kurian, ML Latif… - Arthritis research & …, 2008 - Springer
Introduction Cannabis-based medicines have a number of therapeutic indications, including
anti-inflammatory and analgesic effects. The endocannabinoid receptor system, including …

Visual risk factors for driving difficulty among older drivers

G McGwin Jr, V Chapman, C Owsley - Accident Analysis & Prevention, 2000 - Elsevier
This study sought to evaluate associations between visual function and self-reported
difficulty with driving tasks. Drivers (N= 384) between the ages of 55 and 85 were selected …

Physiological properties of the lamina I spinoparabrachial neurons in the rat

H Bester, V Chapman, JM Besson… - Journal of …, 2000 - journals.physiology.org
Single-unit extracellular recordings of spino-parabrachial (spino-PB) neurons (n= 53)
antidromically driven from the contralateral parabrachial (PB) area were performed in the …

A consensus protocol for functional connectivity analysis in the rat brain

J Grandjean, G Desrosiers-Gregoire, C Anckaerts… - Nature …, 2023 - nature.com
Task-free functional connectivity in animal models provides an experimental framework to
examine connectivity phenomena under controlled conditions and allows for comparisons …

Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography–tandem electrospray ionization mass spectrometry

D Richardson, CA Ortori, V Chapman, DA Kendall… - Analytical …, 2007 - Elsevier
A sensitive and specific liquid chromatography–tandem mass spectrometry (LC–MS/MS)
method is described for the simultaneous identification and quantification of eight …

Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors

MJ Niphakis, AB Cognetta III, JW Chang… - ACS chemical …, 2013 - ACS Publications
Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for
hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2 …

Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of …

SJR Elmes, MD Jhaveri, D Smart… - European Journal of …, 2004 - Wiley Online Library
Peripheral cannabinoid 2 receptors (CB2 receptors) modulate immune responses and
attenuate nociceptive behaviour in models of acute and persistent pain. The aim of the …