User profiles for "author:Ung-il Chung"

Ung-il Chung

University of Tokyo Schools of Engineering and Medicine; Kanagawa University of Human …
Verified email at tetrapod.tu-tokyo.ac.jp
Cited by 23431

Design of hydrogels for biomedical applications

H Kamata, X Li, U Chung… - Advanced healthcare …, 2015 - Wiley Online Library
Hydrogels are considered key tools for the design of biomaterials, such as wound dressings,
drug reservoirs, and temporary scaffolds for cells. Despite their potential, conventional …

[HTML][HTML] Understanding paraxial mesoderm development and sclerotome specification for skeletal repair

S Tani, U Chung, S Ohba, H Hojo - Experimental & Molecular Medicine, 2020 - nature.com
Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues.
However, a deep understanding of skeletal development is required in order to model this …

Design and fabrication of a high-strength hydrogel with ideally homogeneous network structure from tetrahedron-like macromonomers

T Sakai, T Matsunaga, Y Yamamoto, C Ito… - …, 2008 - ACS Publications
As a new class of high-strength hydrogels, we designed a tetra-PEG gel by combining two
symmetrical tetrahedron-like macromonomers of the same size. Because the nanostructural …

[HTML][HTML] PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

T Akune, S Ohba, S Kamekura… - The Journal of …, 2004 - Am Soc Clin Investig
Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and
an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a …

Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis

T Moro, Y Takatori, K Ishihara, T Konno, Y Takigawa… - Nature materials, 2004 - nature.com
Periprosthetic osteolysis—bone loss in the vicinity of a prosthesis—is the most serious
problem limiting the longevity of artificial joints. It is caused by bone-resorptive responses to …

“Nonswellable” hydrogel without mechanical hysteresis

H Kamata, Y Akagi, Y Kayasuga-Kariya, U Chung… - Science, 2014 - science.org
Hydrogels are three-dimensional polymer networks that contain a large amount of water
inside. Certain hydrogels can be injected in solution and transformed into the gel state with …

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

T Saito, A Fukai, A Mabuchi, T Ikeda, F Yano, S Ohba… - Nature medicine, 2010 - nature.com
Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion,
characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 …

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

F Long, U Chung, S Ohba, J McMahon… - 2004 - journals.biologists.com
Indian hedgehog (Ihh) is indispensable for development of the osteoblast lineage in the
endochondral skeleton. In order to determine whether Ihh is directly required for osteoblast …

[HTML][HTML] Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

U Chung, E Schipani, AP McMahon… - The Journal of …, 2001 - Am Soc Clin Investig
Vertebrate skeletogenesis requires a well-coordinated transition from chondrogenesis to
osteogenesis. Hypertrophic chondrocytes in the growth plate play a pivotal role in this …

The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage

T Ikeda, S Kamekura, A Mabuchi, I Kou… - Arthritis & …, 2004 - Wiley Online Library
Objective To regenerate permanent cartilage, it is crucial to know not only the necessary
conditions for chondrogenesis, but also the sufficient conditions. The objective of this study …