Interleukin‐10 suppression of myeloid cell activation—a continuing puzzle

LM Williams, G Ricchetti, U Sarma, T Smallie… - …, 2004 - Wiley Online Library
Efforts to identify the signal transduction pathways used by interleukin‐10 (IL‐10) have
resulted in limited success. The anti‐inflammatory effects elicited by IL‐10, and the …

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

T Krausgruber, K Blazek, T Smallie, S Alzabin… - Nature …, 2011 - nature.com
Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA
expression are associated with many autoimmune diseases. Here we show that IRF5 …

IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3

KJ Staples, T Smallie, LM Williams, A Foey… - The Journal of …, 2007 - journals.aai.org
IL-10 is an important immunosuppressive cytokine that can down-regulate expression of
other cytokines and has been shown to down-regulate itself. We show, in this study, that …

Expression of chemokines CXCL4 and CXCL7 by synovial macrophages defines an early stage of rheumatoid arthritis

L Yeo, N Adlard, M Biehl, M Juarez, T Smallie… - Annals of the …, 2016 - ard.bmj.com
Background and objectives For our understanding of the pathogenesis of rheumatoid
arthritis (RA), it is important to elucidate the mechanisms underlying early stages of synovitis …

Mycolactone inhibits monocyte cytokine production by a posttranscriptional mechanism

RE Simmonds, FV Lali, T Smallie… - The Journal of …, 2009 - journals.aai.org
The virulence and immunosuppressive activity of Mycobacterium ulcerans is attributed to
mycolactone, a macrolide toxin synthesized by the bacteria. We have explored the …

IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages

T Smallie, G Ricchetti, NJ Horwood… - Journal of Experimental …, 2010 - rupress.org
IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the
mechanisms involved remain to be resolved. Using primary human macrophages, we found …

[HTML][HTML] Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and …

T Tang, TE Scambler, T Smallie, HE Cunliffe… - Scientific reports, 2017 - nature.com
In many different cell types, pro-inflammatory agonists induce the expression of
cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of …

A deletion defining a common Asian lineage of Mycobacterium tuberculosis associates with immune subversion

…, AR Martineau, S Fandrich, T Smallie… - Proceedings of the …, 2006 - National Acad Sciences
Six major lineages of Mycobacterium tuberculosis appear preferentially transmitted amongst
distinct ethnic groups. We identified a deletion affecting Rv1519 in CH, a strain isolated from …

Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

…, T Crowley, ML Ridley, J Crowe, T Smallie… - Annals of the …, 2017 - ard.bmj.com
Objectives Tristetraprolin (TTP), a negative regulator of many pro-inflammatory genes, is
strongly expressed in rheumatoid synovial cells. The mitogen-activated protein kinase …

[HTML][HTML] Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages

LM Williams, U Sarma, K Willets, T Smallie… - Journal of Biological …, 2007 - ASBMB
There is general agreement that signal transducer and activation of transcription 3 (STAT3)
is required to mediate the anti-inflammatory activities of interleukin (IL)-10. However, STAT3 …