The immunogenicity of anti-TNF therapy in immune-mediated inflammatory diseases: a systematic review of the literature with a meta-analysis

S Garcês, J Demengeot, E Benito-Garcia - Annals of the rheumatic …, 2013 - ard.bmj.com
Background Immunogenicity of aTNFs is one of the mechanisms behind treatment failure.
Objective To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab …

Managing unwanted immunogenicity of biologicals

M Deehan, S Garcês, D Kramer, MP Baker, D Rat… - Autoimmunity …, 2015 - Elsevier
All protein drugs (biologicals) have an immunogenic potential and we are armed with
multiple guidelines, regulatory documents and white papers to assist us in assessing the …

A preliminary algorithm introducing immunogenicity assessment in the management of patients with RA receiving tumour necrosis factor inhibitor therapies

S Garcês, M Antunes, E Benito-Garcia… - Annals of the …, 2014 - ard.bmj.com
Introduction Clinical remission is today the treatment goal for rheumatoid arthritis (RA),
which requires fast and assertive therapeutic decisions for a tight control of disease activity …

The immunogenicity of biologic therapies

S Garcês, J Demengeot - Adverse Reactions to Biologics, 2018 - karger.com
Virtually all therapeutic proteins (biologics) elicit an immune response with the consequent
production of anti-drug antibodies (ADA). The majority of ADA to therapeutic monoclonal …

The Portuguese Society of Rheumatology position paper on the use of biosimilars.

JE Fonseca, J Gonçalves, F Araújo… - Acta Reumatologica …, 2014 - search.ebscohost.com
Biotechnological drugs have become a fundamental resource for the treatment of rheumatic
patients. Patent expiry of some of these drugs created the opportunity for biopharmaceutical …

[CITATION][C] Febrile headache

S Garcês, MJ Santos, JC Silva - Acta Reumatologica Portuguesa, 2007 - europepmc.org
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Recomendações portuguesas «como diagnosticar, monitorizar e tratar a artrite periférica indiferenciada»: Revisão sistematizada da literatura e opinião de peritos

A Ribeiro, P Machado, S Ramiro… - Acta …, 2010 - science.egasmoniz.com.pt
Objective: The 3E (Evidence, Expertise, Exchange) Initiative is a multinational effort of
rheumatologists aimed at developing evidence-based recommendations addressing …