TWEAK is a novel arthritogenic mediator
SJ Perper, B Browning, LC Burkly, S Weng… - The Journal of …, 2006 - journals.aai.org
TNF-like weak inducer of apoptosis (TWEAK) is a TNF family member with pleiotropic effects
on a variety of cell types, one of which is the induction of proinflammatory cytokines by …
on a variety of cell types, one of which is the induction of proinflammatory cytokines by …
[HTML][HTML] Treatment with a CD40 antagonist antibody reverses severe proteinuria and loss of saliva production and restores glomerular morphology in murine systemic …
SJ Perper, SV Westmoreland, J Karman… - The Journal of …, 2019 - journals.aai.org
CD40 is a costimulatory receptor on APCs that is critical for the induction and maintenance
of humoral and cell-mediated immunity. Accordingly, CD40 and its ligand, CD40L, have long …
of humoral and cell-mediated immunity. Accordingly, CD40 and its ligand, CD40L, have long …
An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat …
…, K Giza, A Gill, BM Dolinski, W Yang, S Perper… - … of Pharmacology and …, 2003 - ASPET
Integrin α4β1 plays an important role in inflammatory processes by regulating the migration
of lymphocytes into inflamed tissues. Here we evaluated the biochemical, pharmacological …
of lymphocytes into inflamed tissues. Here we evaluated the biochemical, pharmacological …
Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE
BE Theien, CL Vanderlugt, C Nickerson-Nutter… - Blood, 2003 - ashpublications.org
Interaction of very late antigen-4 (VLA-4) with its ligand vascular cell adhesion molecule-1
(VCAM-1) is required for central nervous system (CNS) migration of encephalitogenic T cells …
(VCAM-1) is required for central nervous system (CNS) migration of encephalitogenic T cells …
[HTML][HTML] A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
JL Gommerman, K Giza, S Perper… - The Journal of …, 2003 - Am Soc Clin Investig
In studies using genetically deficient mice, a role for the lymphotoxin (LT) system in the
pathogenesis of experimental autoimmune encephalomyelitis (EAE) has remained …
pathogenesis of experimental autoimmune encephalomyelitis (EAE) has remained …
Bcl‐2 as a therapeutic target in human tubulointerstitial inflammation
K Ko, J Wang, S Perper, Y Jiang, D Yanez… - Arthritis & …, 2016 - Wiley Online Library
Objective In lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ
adaptive immune cell networks that amplify local tissue damage. Since conventional therapy …
adaptive immune cell networks that amplify local tissue damage. Since conventional therapy …
A mouse Fcγ-Fcε protein that inhibits mast cells through activation of FcγRIIB, SH2 domain–containing inositol phosphatase 1, and SH2 domain–containing protein …
E Mertsching, L Bafetti, H Hess, S Perper, K Giza… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: A human Fcγ-Fcε fusion protein (GE2) designed to inhibit FcεRI signaling
by coaggregating FcεRI with the inhibitory receptor FcγRIIB has been shown to inhibit mast …
by coaggregating FcεRI with the inhibitory receptor FcγRIIB has been shown to inhibit mast …
[HTML][HTML] IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ
…, Q Zhang, S O'Brien, M Clements, S Perper… - Frontiers in …, 2024 - frontiersin.org
Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma
(SSc), are commonly associated with high morbidity and mortality, thereby representing a …
(SSc), are commonly associated with high morbidity and mortality, thereby representing a …
Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of Integrin α4β1 with improved pharmaceutical properties
…, DR Leone, K Giza, BM Dolinski, S Perper… - … of Pharmacology and …, 2005 - ASPET
Integrin α4β1 plays an important role in inflammatory processes by regulating the migration
of leukocytes into inflamed tissues. Previously, we identified BIO5192 [2 (S)-{[1-(3, 5-dichloro …
of leukocytes into inflamed tissues. Previously, we identified BIO5192 [2 (S)-{[1-(3, 5-dichloro …
Anti‐arthritic effects demonstrated by an interleukin‐2 receptor‐targeted cytotoxin (DAB486IL‐2) in rat adjuvant arthritis
P Bacha, SE Forte, SJ Perper… - European journal of …, 1992 - Wiley Online Library
DAB486IL‐2 is an interleukin‐2 receptor‐specific cytotoxin which selectively targets and kills
cells which bear the high‐affinity form of the IL‐2 receptor. Since elimination of activated T …
cells which bear the high‐affinity form of the IL‐2 receptor. Since elimination of activated T …