Selective immunoglobulin A deficiency (IgAD) is the most common primary
immunodeficiency in Caucasians. It has previously been suggested to be associated with a …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

Background Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in
which the risk of disease is influenced by complex genetic and environmental contributions …

Objective To evaluate the prevalence and predictive value of anti–cyclic citrullinated peptide
(anti‐CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) …

Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …

Objective To investigate whether smoking and HLA–DR shared epitope (SE) genes may
interact in triggering immune reactions to citrulline‐modified proteins. Methods In a case …

Objective In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPA s) and
rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these …

Using the Immunochip custom SNP array, which was designed for dense genotyping of 186
loci identified through genome-wide association studies (GWAS), we analyzed 11,475 …

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by
both genetic and environmental factors. Genome scans in families with SLE point to multiple …

Objective Because treatment with tumor necrosis factor (TNF) antagonists may increase the
risk of tuberculosis (TB), and because knowledge of the risk of TB in rheumatoid arthritis …