From randomized controlled trials to observational studies

SL Silverman - The American journal of medicine, 2009 - Elsevier
Randomized controlled trials are considered the gold standard in the hierarchy of research
designs for evaluating the efficacy and safety of a treatment intervention. However, their …

A systematic review of persistence and compliance with bisphosphonates for osteoporosis

JA Cramer, DT Gold, SL Silverman… - Osteoporosis …, 2007 - Springer
Fourteen reports utilizing data from de-identified administrative databases were reviewed.
Studies contained at least one measure of patient persistence or compliance with …

Impact of osteoporosis treatment adherence on fracture rates in North America and Europe

ES Siris, PL Selby, KG Saag, F Borgström… - The American journal of …, 2009 - Elsevier
Fragility fractures associated with osteoporosis constitute a significant public health concern.
Clinical trials have shown that a variety of agents—bisphosphonates, raloxifene, calcitonin …

Bisphosphonate‐associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research

S Khosla, D Burr, J Cauley… - Journal of bone and …, 2007 - academic.oup.com
ONJ has been increasingly suspected to be a potential complication of bisphosphonate
therapy in recent years. Thus, the ASBMR leadership appointed a multidisciplinary task …

Risk of new vertebral fracture in the year following a fracture

R Lindsay, SL Silverman, C Cooper, DA Hanley… - Jama, 2001 - jamanetwork.com
ContextVertebral fractures significantly increase lifetime risk of future fractures, but risk of
further vertebral fractures in the period immediately following a vertebral fracture has not …

Fractures attributable to osteoporosis: report from the National Osteoporosis Foundation

LJ Melton III, M Thamer, NF Ray… - Journal of Bone and …, 1997 - academic.oup.com
To assess the cost‐effectiveness of interventions to prevent osteoporosis, it is necessary to
estimate total health care expenditures for the treatment of osteoporotic fractures. Resources …

Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A Department of Veterans Affairs Cooperative Study

DO Clegg, DJ Reda, E Mejias, GW Cannon… - Arthritis & …, 1996 - Wiley Online Library
Objective. To determine whether sulfasalazine (SSZ) at a dosage of 2,000 mg/day is
effective for the treatment of active psoriatic arthritis (PsA) resistant to nonsteroidal …

Efficacy of bazedoxifene in reducing new vertebral fracture risk in postmenopausal women with osteoporosis: results from a 3‐year, randomized, placebo‐, and active …

SL Silverman, C Christiansen… - Journal of bone and …, 2008 - academic.oup.com
Abstract In this 3‐yr, randomized, double‐blind, placebo‐and active‐controlled study,
healthy postmenopausal women with osteoporosis (55–85 yr of age) were treated with …

Incidence of atypical nontraumatic diaphyseal fractures of the femur

RM Dell, AL Adams, DF Greene… - Journal of Bone and …, 2012 - academic.oup.com
Bisphosphonates reduce the rate of osteoporotic fractures in clinical trials and community
practice.“Atypical” nontraumatic fractures of the diaphyseal (subtrochanteric or shaft) part of …

Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study

JY Reginster, S Adami, P Lakatos… - Annals of the …, 2006 - ard.bmj.com
Background: Reducing bisphosphonate dosing frequency may improve suboptimal
adherence to treatment and therefore therapeutic outcomes in postmenopausal …