Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis

JS Knight, W Luo, AA O'Dell, S Yalavarthi… - Circulation …, 2014 - Am Heart Assoc
Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage,
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in …

[HTML][HTML] Activated signature of antiphospholipid syndrome neutrophils reveals potential therapeutic target

JS Knight, H Meng, P Coit, S Yalavarthi, G Sule… - JCI insight, 2017 - ncbi.nlm.nih.gov
Antiphospholipid antibodies, present in one-third of lupus patients, increase the risk of
thrombosis. We recently reported a key role for neutrophils—neutrophil extracellular traps …

Endothelial progenitor dysfunction associates with a type I interferon signature in primary antiphospholipid syndrome

RC Grenn, S Yalavarthi, AA Gandhi… - Annals of the …, 2017 - ard.bmj.com
Objectives Patients with antiphospholipid syndrome (APS) are at risk for subclinical
endothelial injury, as well as accelerated atherosclerosis. In the related disease systemic …

Response to:'Monocyte type I interferon signature in antiphospholipid syndrome is related to pro-inflammatory monocyte subsets, hydroxychloroquine and statin use' …

S Yalavarthi, RC Grenn, JS Knight - Annals of the rheumatic diseases, 2016 - ard.bmj.com
Primary antiphospholipid syndrome (APS) is an autoimmune disorder of unknown cause,
characterised by not only thrombotic events and pregnancy morbidity but also accelerated …

[CITATION][C] Antiphospholipid syndrome neutrophils are characterized by overexpression of P-selectin glycoprotein ligand 1, a potential therapeutic target

JS Knight, PS Coit, H Meng… - ARTHRITIS & …, 2016 - … ST, HOBOKEN 07030-5774, NJ USA

[CITATION][C] Peptidylarginine Deiminase Inhibition Prevents Neutrophil Extracellular Trap Formation, Modulates Innate Immune Responses, and Reduces Vascular …

JS Knight, W Luo, AA O'Dell… - ARTHRITIS …, 2013 - … ST, HOBOKEN 07030-5774, NJ USA

[CITATION][C] Primary Antiphospholipid Syndrome Is Characterized By Endothelial Progenitor Dysfunction and a Type I Interferon Signature

RC Grenn, S Yalavarthi… - ARTHRITIS & …, 2015 - … ST, HOBOKEN 07030-5774, NJ USA