The real-time reverse transcription polymerase chain reaction (RT-qPCR) addresses the
evident requirement for quantitative data analysis in molecular medicine, biotechnology …

Among the many factors that determine the sensitivity, accuracy, and reliability of a real-time
quantitative reverse transcription polymerase chain reaction (qRT–PCR) 1 assay, template …

Background Although targeted biological treatments have transformed the outlook for
patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is …

There is a current imperative to unravel the hierarchy of molecular pathways that drive the
transition of early to established disease in rheumatoid arthritis (RA). Herein, we report a …

Objectives To unravel the hierarchy of cellular/molecular pathways in the disease tissue of
early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship …

Background Colorectal cancers displaying high-degree microsatellite instability (MSI-H)
have an improved prognosis compared to microsatellite stable (MSS) cancers. The …

Objective To establish whether synovial pathobiology improves current clinical classification
and prognostic algorithms in early inflammatory arthritis and identify predictors of …

Objectives: To assess whether the histopathological features of the synovium before starting
treatment with the TNFi certolizumab-pegol could predict clinical outcome and examine the …

Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic
drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped …

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA)
pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through …