In inflammatory conditions such as RA, the neutrophil has tended to be dismissed as a short-
lived, terminally differentiated, irrelevant bystander cell. However, this is clearly not the case …

Of all cells implicated in the pathology of rheumatoid arthritis (RA), neutrophils possess the
greatest cytotoxic potential, owing to their ability to release degradative enzymes and …

This study documents expression of dopamine (DA) receptors on leukocyte subpopulations
using flow cytometric techniques to identify dopamine receptors with subtype-specific …

The continuing morbidity of patients with vasculitis despite the improved prognosis with
aggressive therapy, underlines the need for accurate disease assessment We have devised …

Several new treatment modalities with different mechanisms of action have been studied in
patients with Behçet's syndrome (BS). The aim of the current effort was to update the …

Background Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid
arthritis. The Oral Rheumatoid Arthritis triaL (ORAL) Strategy aimed to assess the …

It is commonly assumed that human neutrophils possess few, if any, functional mitochondria
and that they do not depend on these organelles for cell function. We have used the …

OBJECTIVES To investigate the potential relation between cumulative exposure to cigarette
smoking in patients with or without rheumatoid arthritis (RA) and a positive family history of …

Background Although targeted biological treatments have transformed the outlook for
patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is …

Interleukin-6 is currently attracting significant interest as a potential therapeutic target in
systemic sclerosis (SSc). In this paper, the biology of interleukin-6 is reviewed, and the …