Background: Leflunomide is the prodrug of the disease modifying antirheumatic metabolite
A77 1726. More than 50% of patients withdraw from leflunomide treatment within one year …

The reaction of the enamine 4 with different β‐amino ketone hydrochlorides 3a–e affords the
diketones 5a–e which can be cyclized to the corresponding mono‐and disubstituted …

The Heck-type crosscoupling reaction in DMF under phase-transfer conditions of zinc (II)-
monobromo-deuteroporphyrin-dimethylester (1) and several bifunctional α, β-unsaturated …

Our investigations into the chemistry of preformed iminium salts* 1 have led us to look for
appropriate iminium systems with an aliphatic or aromatic fragment substituted for one of the …

The development of a simple and general method for the preparation of multifunctional
terpyridines is described. The treatment of the ketones 1a–g with ternary iminium salts …

An annelation reaction is presented in which 1, 3‐cyclohexanedione (1) and Mannich bases
6a, b are used for the preparation of functionalized bipyridines 12a, 13a, 14a and …

The preparation of polycyclic heterocycles with one or more nitrogen atoms and different
binding angles by a domino reaction is described. These compounds (4–6, 8a–b) are …

A one‐pot reaction using 1, x‐cyclohexanediones, a Mannich base (or its hydrochloride),
and ammonium acetate delivers novel pyridines or 3, 3′‐bridged bipyridine compounds 8 …

A comparison was made between the energy and the accelerometer methods of computing
drag coefficients from flight tests of the P-51B and the P-39N airplanes. The energy method …

The selective cyclodimerization of monomeric diisocyanates like IPDI 4 and TDI 5 yields [1,
3] diazetidine‐2, 4‐diones (uretdiones). On this basis, a new method for the selective …