Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

N Wegner, K Lundberg, A Kinloch, B Fisher… - Immunological …, 2010 - Wiley Online Library
Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating
evidence of pathogenic disease‐specific autoimmunity to citrullinated proteins. Citrullination …

Periodontitis in RA—the citrullinated enolase connection

K Lundberg, N Wegner, T Yucel-Lindberg… - Nature Reviews …, 2010 - nature.com
Autoimmunity in rheumatoid arthritis (RA) is characterized by an antibody response to
citrullinated proteins. Two of the risk factors for RA—HLA-DRB1 shared epitope alleles and …

[HTML][HTML] Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?

P Mangat, N Wegner, PJ Venables… - Arthritis research & …, 2010 - Springer
Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into
peptidylcitrulline. Citrullination by human PADs is important in normal physiology and …

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α‐enolase: Implications for autoimmunity in rheumatoid arthritis

N Wegner, R Wait, A Sroka, S Eick… - Arthritis & …, 2010 - Wiley Online Library
Objective To investigate protein citrullination by the periodontal pathogen Porphyromonas
gingivalis as a potential mechanism for breaking tolerance to citrullinated proteins in …

Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase

K Lundberg, A Kinloch, BA Fisher… - … : Official Journal of …, 2008 - Wiley Online Library
Objective To map the antibody response to human citrullinated α‐enolase, a candidate
autoantigen in rheumatoid arthritis (RA), and to examine cross‐reactivity with bacterial …

[HTML][HTML] Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis

A Kinloch, V Tatzer, R Wait, D Peston… - Arthritis research & …, 2005 - Springer
Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA), but
little is understood about their citrullinated target antigens. We have detected a candidate …

Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis

H Mahdi, BA Fisher, H Källberg, D Plant, V Malmström… - Nature …, 2009 - nature.com
Gene-environment associations are important in rheumatoid arthritis (RA) susceptibility, with
an association existing between smoking, HLA-DRB1'shared epitope'alleles, PTPN22 and …

[HTML][HTML] Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD …

KJ Maresz, A Hellvard, A Sroka, K Adamowicz… - PLoS …, 2013 - journals.plos.org
Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in
humans and are associated with each other both clinically and epidemiologically. Recent …

Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis

A Kinloch, K Lundberg, R Wait… - … : Official Journal of …, 2008 - Wiley Online Library
Objective To examine synovial fluid as a site for generating citrullinated antigens, including
the candidate autoantigen citrullinated α‐enolase, in rheumatoid arthritis (RA). Methods …

Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles

O Snir, M Widhe, C von Spee, J Lindberg… - Annals of the …, 2009 - ard.bmj.com
Background: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most
patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) …