Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients
AH Sawalha, M Zhao, P Coit, Q Lu - Clinical Immunology, 2020 - Elsevier
Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …
Patients with a compromised immune system are expected to be more susceptible to a …
Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus …
Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …
[PDF][PDF] Identification of multiple genetic susceptibility loci in Takayasu arteritis
Takayasu arteritis is a rare inflammatory disease of large arteries. The etiology of Takayasu
arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is …
arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is …
Genome‐wide DNA methylation patterns in naive CD4+ T cells from patients with primary Sjögren's syndrome
Objective Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with
incompletely understood etiology. This study was undertaken to investigate the role of …
incompletely understood etiology. This study was undertaken to investigate the role of …
Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA …
Background The aetiology of systemic sclerosis (SSc) is not clear, but there is an emerging
evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc. Methods We …
evidence of gene-specific epigenetic dysregulation in the pathogenesis of SSc. Methods We …
Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils
P Coit, S Yalavarthi, M Ognenovski, W Zhao… - Journal of …, 2015 - Elsevier
Recent evidence suggests that neutrophils play an important role in the pathogenesis of
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …
lupus. The goal of this study was to characterize the epigenetic architecture, by studying the …
Identification of multiple independent susceptibility loci in the HLA region in Behcet's disease
Behçet's disease is an inflammatory disease characterized by recurrent oral and genital
ulcers and significant organ involvement. Localizing the genetic association between HLA …
ulcers and significant organ involvement. Localizing the genetic association between HLA …
The human microbiome in rheumatic autoimmune diseases: A comprehensive review
P Coit, AH Sawalha - Clinical Immunology, 2016 - Elsevier
The human microbiome consists of the total diversity of microbiota and their genes. High-
throughput sequencing has allowed for inexpensive and rapid evaluation of taxonomic …
throughput sequencing has allowed for inexpensive and rapid evaluation of taxonomic …
Renal involvement in lupus is characterized by unique DNA methylation changes in naïve CD4+ T cells
P Coit, P Renauer, MA Jeffries, JT Merrill… - Journal of …, 2015 - Elsevier
Systemic lupus erythematosus is a multi-system disease characterized by wide-spread DNA
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …
methylation changes. To identify epigenetic susceptibility loci for lupus nephritis, genome …
Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet's disease
Behçet's disease (BD) is characterized by recurrent oro-genital ulcers, mucocutaneous
lesions, and serious organ involvement. We investigated the salivary microbiome in BD …
lesions, and serious organ involvement. We investigated the salivary microbiome in BD …