Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis |
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MicroRNAs (miRNAs) are short non-coding RNA species which are important post-
transcriptional regulators of gene expression and play an important role in the pathogenesis …

Background & Aims Intestinal fibrosis is a long-term complication in inflammatory bowel
diseases (IBD) that frequently results in functional damage, bowel obstruction, and surgery …

Objectives Determine global skin transcriptome patterns of early diffuse systemic sclerosis
(SSc) and how they differ from later disease. Methods Skin biopsy RNA from 48 patients in …

The arrival of next-generation sequencing (NGS) technologies has led to novel opportunities
for expression profiling and genome analysis by utilizing vast amounts of short read …

Introduction Palmoplantar pustulosis (PPP) is a chronic, inflammatory skin disease, with high
disease burden, that is often refractory to treatment. There is a high unmet clinical need for …

Combining single-cell RNA sequencing (scRNA-seq) with upstream cell preservation
procedures such as cryopreservation or methanol fixation has recently become more …

Background Normalization of microarrays is a standard practice to account for and minimize
effects which are not due to the controlled factors in an experiment. There is an …

Background IL-23 contributes to the activation, maintenance, and proliferation of TH 17 cells
and plays a major role in psoriasis pathophysiology. IL-23p19 inhibition with risankizumab …

Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive
pulmonary disease (COPD) are far from being understood. Here, we determine disease …