Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by a
heterogeneous clinical response to the different treatments. Some patients are difficult to …

The relationship between the complement system and autoimmunity appears paradoxical as
both the deficiency and the activation contribute to inducing autoimmune diseases. In these …

Rheumatoid arthritis (RA) and autoimmune thyroid disease (AITD) can occur in the same
patient in the autoimmune polyglandular syndrome 2. The association of the two conditions …

IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an
important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated …

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that may be present in near 30% of
patients affected by psoriasis (PsO), clinically characterized by inflammation of periarticular …

Psoriasis (PsO) is an autoimmune disease characterized by keratinocyte proliferation,
chronic inflammation and mast cell activation. Up to 42% of patients with PsO may present …

Natural killer (NK) cells are large, granular lymphocytes devoted to the defense against
microbial agents and cancer cells, traditionally recognized as an important arm of the innate …

Retinopathy in systemic lupus erythematosus (SLE) has an incidence of 7%–29% and is
suggestive of high disease activity being a marker of poor visual outcome and prognosis for …

Pregnancy requires a special management in women with inflammatory rheumatic diseases
(RDs), with the aim of controlling maternal disease activity and avoiding fetal complications …

Background Secukinumab (SEC) is effective for ankylosing spondylitis (AS) and psoriatic
arthritis (PsA) in randomized trials, but real-life data are lacking. Research design and …