Inflammasomes are multiprotein complexes that critically control different aspects of innate
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …

Objective Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis (PAAND) is a
recently described monogenic autoinflammatory disease. The causal p. S242R MEFV …

Background To our knowledge, the characteristics and burden of childhood arthritis have
never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional …

The zebrafish has become an excellent model for the study of inflammation and immunity. Its
unique advantages for in vivo imaging and gene and drug screening have allowed the …

Nicotinamide adenine dinucleotide (NAD+) is the most important hydrogen carrier in cell
redox reactions. It is involved in mitochondrial function and metabolism, circadian rhythm …

Background Postzygotic de novo mutations lead to the phenomenon of gene mosaicism.
The 3 main types are called somatic, gonadal, and gonosomal mosaicism, which differ in …

The coronavirus disease 2019 (COVID-19) pandemic turned the whole world upside down
in a short time. One of the main challenges faced has been to understand COVID-19 …

Tumor-necrosis-factor-α inhibitors (anti-TNF-α) are associated with an increased risk of
tuberculosis (TB) disease, primarily due to reactivation of latent TB infection (LTBI). We …

Background Plasma concentrations of lipoprotein (a)(Lp (a)), a lipoprotein with atherogenic
and thrombogenic properties, have a strong genetic basis, although high concentrations of …

Hematopoiesis is a complex process through which immature bone marrow precursor cells
mature into all types of blood cells. Although the association of hematopoietic lineage bias …