Genotoxicity testing aims to detect a large range of genetic damage endpoints and evaluate
such results in context of cell survival. The cytokinesis block micronucleus test offers the …

Brain metastases are associated with a dismal prognosis. Whether brain metastases harbor
distinct genetic alterations beyond those observed in primary tumors is unknown. We …

Therapeutic angiogenesis is likely to require the administration of factors that complement
each other. Activation of the receptor tyrosine kinase (RTK) Flk1 by vascular endothelial …

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
a clinically and genetically heterogeneous disease that is further classified into …

Meningiomas are the most common primary nervous system tumor. The tumor suppressor
NF2 is disrupted in approximately half of all meningiomas, but the complete spectrum of …

Background Follicular lymphoma is a clinically and genetically heterogeneous disease, but
the prognostic value of somatic mutations has not been systematically assessed. We aimed …

Abstract Knowledge of “actionable” somatic genomic alterations present in each tumor (eg,
point mutations, small insertions/deletions, and copy-number alterations that direct …

Craniopharyngiomas are epithelial tumors that typically arise in the suprasellar region of the
brain. Patients experience substantial clinical sequelae from both extension of the tumors …

Primary central nervous system lymphomas (PCNSLs) and primary testicular lymphomas
(PTLs) are extranodal large B-cell lymphomas (LBCLs) with inferior responses to current …

BACKGROUND. Comprehensive genomic profiling of a patient's cancer can be used to
diagnose, monitor, and recommend treatment. Clinical implementation of tumor profiling in …