Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy

SW Tas, PHJ Remans, KA Reedquist… - Current pharmaceutical …, 2005 - ingentaconnect.com
Many chronic inflammatory diseases are associated with deregulated intracellular signal
transduction pathways. Resultant pathogenic interactions between immune and stromal …

Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects

PHJ Remans, JK Sont, LW Wagenaar… - European journal of …, 2004 - nature.com
Objective: To investigate in a double-blind placebo-controlled, parallel group study, the
effects of a nutrient supplement, containing, among other ingredients, the omega-3 fatty …

Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T …

SI Gringhuis, A Leow… - The Journal of …, 2000 - journals.aai.org
The T lymphocytes that reside in the synovium of the inflamed joints in patients with
rheumatoid arthritis display severe hyporesponsiveness upon antigenic stimulation, which is …

Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis

PHJ Remans, M Van Oosterhout… - Arthritis & …, 2005 - Wiley Online Library
Objective To investigate the cellular and molecular sources of oxidative stress in patients
with rheumatoid arthritis (RA) through analysis of the production of reactive oxygen species …

Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes

PHJ Remans, SI Gringhuis, JM van Laar… - The Journal of …, 2004 - journals.aai.org
Transient production of reactive oxygen species (ROS) plays an important role in optimizing
transcriptional and proliferative responses to TCR signaling in T lymphocytes. Conversely …

[HTML][HTML] Real-world efficacy and safety of apremilast in Belgian patients with psoriatic arthritis: results from the prospective observational APOLO study

…, AN Toukap, MJ Kaiser, J Vanhoof, P Remans… - Advances in …, 2022 - Springer
Introduction Apremilast is approved for the treatment of psoriasis and psoriatic arthritis (PsA).
Real-world evidence on the efficacy and safety of apremilast in clinical practice is limited …

Analysis of apoptosis in peripheral blood and synovial tissue very early after initiation of infliximab treatment in rheumatoid arthritis patients

CA Wijbrandts, PH Remans… - … : Official Journal of …, 2008 - Wiley Online Library
Objective Infliximab treatment results in a decrease in synovial cellularity as early as 48
hours after initiation of therapy in patients with rheumatoid arthritis (RA). This study was …

Cerebral vasculitis as a primary manifestation of systemic lupus erythematosus

AT Rowshani, P Remans, A Rozemuller… - Annals of the rheumatic …, 2005 - ard.bmj.com
DISCUSSION This patient had cerebral vasculitis as a primary manifestation of NPSLE
based on psychosis, an earlier episode of polyarthritis, histopathological findings, positive …

CTLA‐4IG suppresses reactive oxygen species by preventing synovial adherent cell–induced inactivation of rap1, a ras family GTPASE mediator of oxidative stress in …

PHJ Remans, CA Wijbrandts… - … : Official Journal of …, 2006 - Wiley Online Library
Objective Oxidative stress contributes to the inflammatory properties of rheumatoid arthritis
(RA) synovial T lymphocytes. This study was undertaken to investigate the mechanisms …

[PDF][PDF] High dose intravenous N-acetyl-L-cysteine (NAC) therapy in rheumatoid arthritis, results from a pilot study.

PHJ Remans, WM Zuijderduin… - Firemans …, 1997 - scholarlypublications …
Objective: to assess feasibility, safety, and efficacy of high dose NAC in patients with RA and
to evaluate its effects on functional parameters of T lymphocytes. Methods: fourteen patients …