A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD)(hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Objective To investigate baseline use of biologic or targeted synthetic (b/ts) disease-
modifying antirheumatic drugs (DMARDs) and COVID-19 outcomes in rheumatoid arthritis …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-
ancestry genetic research of RA promises to improve power to detect genetic signals, fine …

Interstitial lung diseases (ILDs) are a set of heterogeneous lung diseases characterised by
inflammation and, in some cases, fibrosis. These lung conditions lead to dyspnoea, cough …

Question addressed by the study Methotrexate (MTX) is a key anchor drug for rheumatoid
arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication …

The phenotypical, environmental, and genetic similarities between IPF and RA-ILD have led
to a better understanding of the underlying pathogenesis of RA-ILD. Despite the …

Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune
system and connective tissue. SSc stands out as a severely incapacitating and life …

OBJECTIVES: Calcium pyrophosphate (CPP) crystal-induced arthritis occurs particularly in
elderly people. This population has frequently associated comorbidities and treatments …

Despite its high prevalence and mortality, little is known about the pathogenesis of
rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Given that familial …