Top 10 plant viruses in molecular plant pathology

…, K Saunders, T Candresse, P Ahlquist… - Molecular plant …, 2011 - Wiley Online Library
Many scientists, if not all, feel that their particular plant virus should appear in any list of the
most important plant viruses. However, to our knowledge, no such list exists. The aim of this …

RNA-dependent RNA polymerases, viruses, and RNA silencing

P Ahlquist - Science, 2002 - science.org
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA
by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and …

Host factors in positive-strand RNA virus genome replication

P Ahlquist, AO Noueiry, WM Lee, DB Kushner… - Journal of …, 2003 - Am Soc Microbiol
All viruses are gene poor relative to their hosts: even the largest viral genomes only encode
hundreds of genes, while those of host cells typically encode tens of thousands of genes …

Fundamental differences in cell cycle deregulation in human papillomavirus–positive and human papillomavirus–negative head/neck and cervical cancers

…, EM Smith, KT Kelsey, LP Turek, P Ahlquist - Cancer research, 2007 - AACR
Human papillomaviruses (HPV) are associated with nearly all cervical cancers, 20% to 30%
of head and neck cancers (HNC), and other cancers. Because HNCs also arise in HPV …

Detecting differential gene expression with a semiparametric hierarchical mixture method

MA Newton, A Noueiry, D Sarkar, P Ahlquist - Biostatistics, 2004 - academic.oup.com
Mixture modeling provides an effective approach to the differential expression problem in
microarray data analysis. Methods based on fully parametric mixture models are available …

[HTML][HTML] Establishment of human papillomavirus infection requires cell cycle progression

D Pyeon, SM Pearce, SM Lank, P Ahlquist… - PLoS …, 2009 - journals.plos.org
Human papillomaviruses (HPVs) are DNA viruses associated with major human cancers. As
such there is a strong interest in developing new means, such as vaccines and microbicides …

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins

…, A Hildesheim, B Sugden, P Ahlquist - Proceedings of the …, 2008 - National Acad Sciences
Using highly sensitive microarray-based procedures, we identified eight microRNAs
(miRNAs) showing robust differential expression between 31 laser-capture-microdissected …

[HTML][HTML] Drosophila RNAi screen identifies host genes important for influenza virus replication

…, E Sorensen, CA Nidom, MA Newton, P Ahlquist… - Nature, 2008 - nature.com
All viruses rely on host cell proteins and their associated mechanisms to complete the viral
life cycle. Identifying the host molecules that participate in each step of virus replication …

Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories

JA Den Boon, P Ahlquist - Annual review of microbiology, 2010 - annualreviews.org
Positive-strand RNA virus genome replication is invariably associated with extensively
rearranged intracellular membranes. Recent biochemical and electron microscopy …

[HTML][HTML] A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids

…, J Chen, M Janda, M Sullivan, J den Boon, P Ahlquist - Molecular cell, 2002 - cell.com
We show that brome mosaic virus (BMV) RNA replication protein 1a, 2a polymerase, and a
cis-acting replication signal recapitulate the functions of Gag, Pol, and RNA packaging …