Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …

Despite the existing preventative and therapeutic measures, cardiovascular diseases
remain the main cause of temporary disability, long-term disability, and mortality. Obesity is a …

Background Interferon alfa is widely used for metastatic renal-cell carcinoma but has limited
efficacy and tolerability. Temsirolimus, a specific inhibitor of the mammalian target of …

Background Macitentan is beneficial for long-term treatment of pulmonary arterial
hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension …

Background Treatment of venous thromboembolism in children is based on data obtained in
adults with little direct documentation of its efficacy and safety in children. The aim of our …

Objectives Mavrilimumab, a human monoclonal antibody targeting the alpha subunit of the
granulocyte-macrophage colony-stimulating factor receptor, was evaluated in a phase 2 …

Summary Background The triglyceride glucose (TyG) index is an easily accessible surrogate
marker of insulin resistance, an important pathway in the development of type 2 diabetes …

Epigenetic mechanisms of gene regulation in context of cardiovascular diseases are of
considerable interest. So far, our current knowledge of the DNA methylation profiles for …

Background The prevalence of familial hypercholesterolemia (FH) in Russia has not
previously been evaluated. The aim of our study was to investigate the prevalence of FH in …

Valvular calcification precedes the development of valvular stenosis and may represent an
important early phenotype for valvular heart disease. It is known that development of …