Objectives Treat-to-target recommendations have identified 'remission'as a target in
systemic lupus erythematosus (SLE), but recognise that there is no universally accepted …

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical
manifestations affecting different tissues. A characteristic feature of SLE is the presence of …

Systemic lupus erythematosus is an inflammatory autoimmune syndrome of unknown cause.
Kidney disease is a central and serious complication in this syndrome. Deposition of …

Antibodies to dsDNA represent a classification criterion for systemic lupus erythematosus.
Subpopulations of these antibodies are involved in lupus nephritis. No known marker …

Background Lupus nephritis is characterized by deposition of chromatin fragment-IgG
complexes in the mesangial matrix and glomerular basement membranes (GBM). The latter …

A role for polyomaviruses in the pathogenesis of systemic lupus erythematosus (SLE) has
been suggested. BK virus (BKV) and JC virus (JCV) were demonstrated in single urine …

We have previously demonstrated that experimental expression of the polyomavirus
transcription factor T-antigen has the potential to induce anti-DNA antibodies in mice. Two …

This study aims to understand what lupus nephritis is, its origin, clinical context, and its
pathogenesis. Truly, we encounter many conceptual and immanent tribulations in our …

Background Deposition of chromatin-IgG complexes within glomerular membranes is a key
event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal …

Although the origin of autoimmune antibodies to double-stranded DNA is not known, the
variable-region structures of such antibodies indicate that they are produced in response to …