The mechanisms and consequences of the extra-pulmonary dissemination of Mycobacterium tuberculosis

N Krishnan, BD Robertson, G Thwaites - Tuberculosis, 2010 - Elsevier
The dissemination of Mycobacterium tuberculosis from the primary focus of infection is
central to the pathogenesis of tuberculosis. Trafficking of bacteria to the regional lymph …

[HTML][HTML] Mycobacterium tuberculosis Lineage Influences Innate Immune Response and Virulence and Is Associated with Distinct Cell Envelope Lipid Profiles

N Krishnan, W Malaga, P Constant, M Caws… - PloS one, 2011 - journals.plos.org
The six major genetic lineages of Mycobacterium tuberculosis are strongly associated with
specific geographical regions, but their relevance to bacterial virulence and the clinical …

Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence

N Andreu, T Fletcher, N Krishnan… - Journal of …, 2012 - academic.oup.com
Objectives Tuberculosis drug development is hampered by the slow growth of
Mycobacterium tuberculosis. Bioluminescence, light produced by an enzymatic reaction …

[HTML][HTML] Effective delivery of the anti-mycobacterial peptide NZX in mesoporous silica nanoparticles

E Tenland, A Pochert, N Krishnan… - PLoS …, 2019 - journals.plos.org
Background Intracellular delivery of antimicrobial agents by nanoparticles, such as
mesoporous silica particles (MSPs), offers an interesting strategy to treat intracellular …

Platelets regulate pulmonary inflammation and tissue destruction in tuberculosis

KA Fox, DE Kirwan, AM Whittington… - American journal of …, 2018 - atsjournals.org
Rationale: Platelets may interact with the immune system in tuberculosis (TB) to regulate
human inflammatory responses that lead to morbidity and spread of infection. Objectives: To …

Unnatural amino acid analogues of membrane-active helical peptides with anti-mycobacterial activity and improved stability

JS Khara, M Priestman, I Uhia… - Journal of …, 2016 - academic.oup.com
Objectives The emergence of MDR-TB, coupled with shrinking antibiotic pipelines, has
increased demands for new antimicrobials with novel mechanisms of action. Antimicrobial …

Inhalable poly (lactic-co-glycolic acid)(PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium …

G O'Connor, N Krishnan, A Fagan-Murphy… - European Journal of …, 2019 - Elsevier
Ending the tuberculosis (TB) epidemic by 2030 was recently listed in the United Nations
(UN) Sustainable Development Goals alongside HIV/AIDS and malaria as it continues to be …

[HTML][HTML] A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis

E Tenland, N Krishnan, A Rönnholm, S Kalsum… - Tuberculosis, 2018 - Elsevier
Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the
world. Co-infection with HIV and the increase in multi-drug resistant Mycobacterium …

[HTML][HTML] Pathways of IL-1β secretion by macrophages infected with clinical Mycobacterium tuberculosis strains

N Krishnan, BD Robertson, G Thwaites - Tuberculosis, 2013 - Elsevier
The pro-inflammatory cytokine IL-1β is a key mediator of inflammation and plays an
important role in the host resistance to Mycobacterium tuberculosis infections. To date, most …

Deciphering the metabolic response of Mycobacterium tuberculosis to nitrogen stress

KJ Williams, VA Jenkins, GR Barton… - Molecular …, 2015 - Wiley Online Library
A key component to the success of M ycobacterium tuberculosis as a pathogen is the ability
to sense and adapt metabolically to the diverse range of conditions encountered in vivo …