Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study

A Consolaro, G Giancane, A Alongi… - The Lancet Child & …, 2019 - thelancet.com
Background To our knowledge, the characteristics and burden of childhood arthritis have
never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional …

Proinflammatory stimuli induce galectin‐9 in human mesenchymal stromal cells to suppress T‐cell proliferation

F Gieseke, A Kruchen, N Tzaribachev… - European journal of …, 2013 - Wiley Online Library
Human multipotent mesenchymal stromal cells (MSC s) are clinically applied to treat
autoimmune diseases and graft‐versus‐host disease due to their immunomodulatory …

Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial

HI Brunner, N Ruperto, N Tzaribachev… - Annals of the …, 2018 - ard.bmj.com
Objective This report aims to determine the safety, pharmacokinetics (PK) and efficacy of
subcutaneous golimumab in active polyarticular-course juvenile idiopathic arthritis (polyJIA) …

Definitions for the sonographic features of joints in healthy children

J Roth, S Jousse-Joulin, S Magni-Manzoni… - Arthritis care & …, 2015 - Wiley Online Library
Objective Musculoskeletal ultrasonography (US) has potential in the assessment of disease
activity and structural damage in childhood arthritides. In order to assess pathology, the US …

Preliminary definitions for the sonographic features of synovitis in children

J Roth, V Ravagnani, M Backhaus… - Arthritis care & …, 2017 - Wiley Online Library
Objective Musculoskeletal ultrasonography (US) has the potential to be an important tool in
the assessment of disease activity in childhood arthritides. To assess pathology, clear …

Rate and clinical presentation of macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis treated with canakinumab

AA Grom, NT Ilowite, V Pascual… - Arthritis & …, 2016 - Wiley Online Library
Objective In pivotal trials, canakinumab has been shown to be effective in the treatment of
systemic juvenile idiopathic arthritis (JIA), but reported adverse events have included …

Juvenile idiopathic arthritis-the role of imaging from a rheumatologist's perspective

C Malattia, N Tzaribachev, JM van den Berg… - Pediatric …, 2018 - Springer
Alongside recent advances in treatment strategies for juvenile idiopathic arthritis (JIA),
paediatric rheumatologists have taken increasing interest in the use of imaging. Magnetic …

Current status of efforts on standardizing magnetic resonance imaging of juvenile idiopathic arthritis: report from the OMERACT MRI in JIA Working Group and Health …

CM Nusman, LSO Muller, R Hemke, AS Doria… - The Journal of …, 2016 - jrheum.org
Objective. To report on the progress of an ongoing research collaboration on magnetic
resonance imaging (MRI) in juvenile idiopathic arthritis (JIA) and describe the proceedings …

[HTML][HTML] Imaging of the knee in juvenile idiopathic arthritis

R Hemke, N Tzaribachev, AM Barendregt… - Pediatric …, 2018 - Springer
In juvenile idiopathic arthritis (JIA), imaging is increasingly used in clinical practice. In this
paper we discuss imaging of the knee, the clinically most commonly affected joint in JIA. In …

Impaired suppression of synovial fluid CD4+ CD25− T cells from patients with juvenile idiopathic arthritis by CD4+ CD25+ Treg cells

S Haufe, M Haug, C Schepp… - Arthritis & …, 2011 - Wiley Online Library
Abstract Objective Natural CD4+ CD25+ FoxP3+ Treg cells play a crucial role in maintaining
immune homeostasis and controlling autoimmunity. In patients with juvenile idiopathic …