Role of TWEAK in lupus nephritis: a bench-to-bedside review
JS Michaelson, N Wisniacki, LC Burkly… - Journal of …, 2012 - Elsevier
There is significant unmet need in the treatment of lupus nephritis (LN) patients. In this
review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic …
review, we highlight the role of the TWEAK/Fn14 pathway in mediating key pathologic …
[HTML][HTML] A randomized, phase II study of sequential belimumab and rituximab in primary Sjögren's syndrome
X Mariette, F Barone, C Baldini, H Bootsma, KL Clark… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Primary Sjögren's syndrome (pSS) is characterized by B cell hyperactivity
and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (eg, belimumab) …
and elevated B-lymphocyte stimulator (BLyS). Anti-BLyS treatment (eg, belimumab) …
Safety, tolerability, pharmacokinetics, and pharmacodynamics of anti-TWEAK monoclonal antibody in patients with rheumatoid arthritis
N Wisniacki, L Amaravadi, GR Galluppi, TS Zheng… - Clinical …, 2013 - Elsevier
Background Persistent upregulation of signaling by cytokine tumor necrosis factor–like weak
inducer of apoptosis (TWEAK) through its receptor fibroblast growth factor–inducible …
inducer of apoptosis (TWEAK) through its receptor fibroblast growth factor–inducible …
[HTML][HTML] A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type …
B Keymeulen, A van Maurik, D Inman, J Oliveira… - Diabetologia, 2021 - Springer
Aims/hypothesis Numerous clinical studies have investigated the anti-CD3ɛ monoclonal
antibody otelixizumab in individuals with type 1 diabetes, but limited progress has been …
antibody otelixizumab in individuals with type 1 diabetes, but limited progress has been …
Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis
KEN Clark, C Campochiaro, E Csomor… - Annals of the …, 2021 - ard.bmj.com
Objectives Clinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark
SSc autoantibodies are central to diagnosis and associate with distinct patterns of skin …
SSc autoantibodies are central to diagnosis and associate with distinct patterns of skin …
Biological and clinical insights from a randomized phase 2 study of an anti-oncostatin M monoclonal antibody in systemic sclerosis
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting
OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc …
OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc …
In vivo affinity and target engagement in skin and blood in a first‐time‐in‐human study of an anti‐oncostatin M monoclonal antibody
J Reid, S Zamuner, K Edwards… - British Journal of …, 2018 - Wiley Online Library
Aims The oncostatin M (OSM) pathway drives fibrosis, inflammation and vasculopathy, and
is a potential therapeutic target for inflammatory and fibrotic diseases. The aim of this first …
is a potential therapeutic target for inflammatory and fibrotic diseases. The aim of this first …
[HTML][HTML] The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis
G Marden, Q Wan, J Wilks, K Nevin, M Feeney… - Arthritis research & …, 2020 - Springer
Abstract Background Scleroderma (SSc) is a rare autoimmune disease characterized by
vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a …
vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a …
[HTML][HTML] Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study
KEN Clark, E Csomor, C Campochiaro… - The Lancet …, 2022 - thelancet.com
Background Skin fibrosis is a hallmark feature of systemic sclerosis. Skin biopsy
transcriptomics and blister fluid proteomics give insight into the local environment of the skin …
transcriptomics and blister fluid proteomics give insight into the local environment of the skin …
Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis
Purpose To identify potential biomarkers of the renal impairment in lupus nephritis using a
multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging …
multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging …