Sandwich-cultured hepatocytes (SCH) are a powerful in vitro tool that can be utilized to
study hepatobiliary drug transport, species differences in drug transport, transport protein …

Hepatic efflux transporters include numerous well-known and emerging proteins localized to
the canalicular or basolateral membrane of the hepatocyte that are responsible for the …

Background Adalimumab has been used in patients with moderately to severely active
rheumatoid arthritis (RA) for over 10 years and has a well-established safety profile across …

Transporters responsible for hepatic uptake and biliary clearance (CLBile) of rosuvastatin
(RSV) have been well characterized. However, the contribution of basolateral efflux …

Severe coronavirus disease 2019 (COVID-19) is characterised by pneumonia with
excessive systemic inflammation, referred to as a “cytokine storm”[1–3]. Dexamethasone …

The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired
BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the …

Abstract Nezulcitinib (TD‐0903), a lung‐selective pan–Janus‐associated kinase (JAK)
inhibitor designed for inhaled delivery, is under development for treatment of acute lung …

OATP1B1, OATP1B3 and OATP2B1 are important members of the organic anion
transporting polypeptides (OATP) family and are implicated in the hepatic disposition of …

Prediction of clinical efficacy, toxicity, and drug-drug interactions may be improved by
accounting for the intracellular unbound drug concentration (C unbound) in vitro and in vivo …

Background This study assessed the efficacy and safety of velusetrag—a 5‐HT4 agonist
with pan‐gastrointestinal prokinetic activity—for gastroparesis symptom management and …